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ChemicalBook CAS DataBase List 2-(TRIFLUOROMETHYL)BENZYLAMINE
3048-01-9

2-(TRIFLUOROMETHYL)BENZYLAMINE synthesis

7synthesis methods
-

Yield:-

Reaction Conditions:

Stage #1: 1-(azidomethyl)-2-(trifluoromethyl)benzenewith hydrogenchloride;tin(ll) chloride in water at 80; for 2 h;
Stage #2: with sodium hydrogencarbonate in water;

Steps:

4.2

Step 2 -Preparation of 1-[2-(trifluoromethyl)phenyl]methanamine To a solution of step-1 intermediate (0.200 g, 0.993 mmol) in conc. HCl tin (II)chloride (0.673 g, 2.98 mmol) was added. The reaction mixture was stirred at 80° C. for 2 h. The reaction mixture quenched in water, neutralized with sodium bicarbonate and extracted with mixture of (1-1.5%) methanol: DCM. The organic layer was separated, dried over anhydrous sodium sulphate and concentrated to afford 0.150 g of the desired product. 1HNMR (DMSO-d6): δ 7.43 (d, J=7.2 Hz, 2H), 7.64-7.66 (m, 3H), 7.78 (m, 1H).

References:

US2012/108583,2012,A1 Location in patent:Page/Page column 23

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