Yield:-

Reaction Conditions:

with hydrogen;Raney Ni in ethanol under 2585.81 Torr;

Steps:

45
(4-Fluoro-2-(trifluoromethyl)phenyl)methanamine To a solution of 4-fluoro-2-(trifluoromethyl)benzonitrile (2.0 g) in ethanol (10.0 mL) was added Raney Ni (catalytic amount). The reaction mixture was subjected for hydrogenation in Parr apparatus under 50 psi for 2-3 h. The reaction mass filtered through celite and concentrated the filtrate to afford 0.400 g of the desired product. ¹HNMR (CDCl₃): δ 3.98 (s, 2H), 7.24 (t, J=9.0 Hz, 1H), 7.34 (d, J=8.7 Hz, 1H), 7.54 (t, J=7.8 Hz, 1H); MS [M+H]⁺: 194.03.

References:

Glenmark Pharmaceuticals S.A. US2012/108583, 2012, A1 Location in patent:Page/Page column 36