2-Chloro-3-fluoronitrobenzene synthesis
- Product Name:2-Chloro-3-fluoronitrobenzene
- CAS Number:21397-07-9
- Molecular formula:C6H3ClFNO2
- Molecular Weight:175.54
402-67-5
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21397-07-9
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Yield:21397-07-9 79.8%
Reaction Conditions:
with hexachloroethane;lithium tert-butoxide in N,N-dimethyl-formamide at 60; for 4 h;Inert atmosphere;regioselective reaction;
Steps:
Synthetic procedure of compound 6
A solution of 1-fluoro-3-nitrobenzene (1.41g, 10mmol), t-BuOLi (2.00g, 25mmol) and C2Cl6 (4.73g, 20 mmol) in 15ml dry DMF was stirred for 4h at 60°C under N2 atmosphere. Ethyl acetate was added and the resulting organic solution was washed by 1M HCl, saturated NaHCO3 and brine successively. The solvent was removed under reduced pressure and the residue was purified on column chromatography (eluted by 0.5% ethyl acetate in petroleum ether) to obtain 6 as a colorless oil. Yield: 79.8%, 1H NMR (400 MHz, CDCl3) δ 7.77-7.69 (m, 1H, Ph-H), 7.48-7.41 (m, 2H, Ph-H).
References:
Wei, Wei;Zhou, Shaa;Cheng, Dandan;Li, Yuxin;Liu, Jingbo;Xie, Yongtao;Li, Yonghong;Li, Zhengming [Bioorganic and Medicinal Chemistry Letters,2017,vol. 27,# 15,p. 3365 - 3369] Location in patent:supporting information
611-06-3
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446-35-5
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21397-07-9
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602-03-9
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399-31-5
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21397-07-9
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342-52-9
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21397-07-9
130 suppliers
$30.00/1g