ChemicalBook CAS DataBase List 3-Chloro-4-fluoronitrobenzene

3-Chloro-4-fluoronitrobenzene synthesis

9synthesis methods

Product Name:3-Chloro-4-fluoronitrobenzene
CAS Number:350-30-1
Molecular formula:C6H3ClFNO2
Molecular Weight:175.54

350-46-9 Synthesis

350-46-9
515 suppliers
$10.60/1gm:

350-30-1
326 suppliers
$14.00/1g

Yield:350-30-1 75%

Reaction Conditions:

with N-chloro-succinimide;sulfuric acid;iodine;nitric acid at 20; for 2 h;Reagent/catalyst;Concentration;

Steps:

6 Example 6
35 mmol (5 g) of p-fluoronitrobenzene was suspended in 15 mL of a 20% solution of nitric acid and sulfuric acid (1: 1) by volume,In the presence of iodine (0.5 g) catalysis, 42 mmol (5.6 g) of N-chlorosuccinimide,The reaction was completed at room temperature for 2 hours. The reaction was completed, diluted with 30 mL of water, extracted with ethyl acetate (3 × 30 mL), washed with 20% sodium thiosulfate (2 × 20 mL) and 20 mL of brine, dried over anhydrous sodium sulfate, After evaporation to give the crude 3-chloro-4-fluoronitrobenzene, the crude product was recrystallized from methanol to give pure 3-chloro-4-fluoronitrobenzene 4.6g, a yield of 75%.

References:

Shandong Youbang Biochemical Technology Co., Ltd.;Wang Lei;Yang Rui;Li Juan;Han Meng;Wu Feilong;Lai Xinsheng;Lai Chao;Lai Ziteng CN106631811, 2017, A Location in patent:Paragraph 0012; 0013; 0014; 0015; 0016; 0017; 0018

FullText

99-54-7 Synthesis