P-5091
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- $28 - $1802
- Product name: P-5091
- CAS: 882257-11-6
- MF: C12H7Cl2NO3S2
- MW: 348.22
- EINECS:
- MDL Number:MFCD00123202
- Synonyms:1-[5-(2,3-dichlorophenyl)sulfanyl-4-nitro-2-thienyl]ethanone;P5091, >=98%;1-[5-(2,3-Dichloro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone;Ethanone, 1-[5-[(2,3-dichlorophenyl)thio]-4-nitro-2-thienyl]-;1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]-ethanone P005091;P 005091;P 5091;P005091
39 prices
Selected condition：
Brand
- Acints
- Advanced Chemicals Intermediatesced Chemicals Intermediates
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 5mg
- 10
- 25mg
- 100mg
- 250mg
- 1000mg
- 50
- 10mM(in 1mL DMSO)
- 1mg
- 1unit
- 2mg
- 10mg
- 50mg
- 1g
- 5g
- ManufacturerAcints
- Product numberACI-02006
- Product description1-[5-(2,3-Dichloro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone 95%+
- Packaging1g
- Price$427.75
- Updated2021-12-16
- Buy
- ManufacturerAcints
- Product numberACI-02006
- Product description1-[5-(2,3-Dichloro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone 95%+
- Packaging5g
- Price$1297.75
- Updated2021-12-16
- Buy
- ManufacturerAdvanced Chemicals Intermediatesced Chemicals Intermediates
- Product numberACI-02006
- Product description1-[5-(2,3-Dichloro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone 95%+
- Packaging1g
- Price$427.75
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberY1893
- Product description1-(5-(2,3-dichlorophenylthio)-4-nitrothiophen-2-yl)ethanone
- Packaging1mg
- Price$104
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberY1893
- Product description1-(5-(2,3-dichlorophenylthio)-4-nitrothiophen-2-yl)ethanone
- Packaging2mg
- Price$116
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberY1893
- Product description1-(5-(2,3-dichlorophenylthio)-4-nitrothiophen-2-yl)ethanone
- Packaging10mg
- Price$170
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberY1893
- Product description1-(5-(2,3-dichlorophenylthio)-4-nitrothiophen-2-yl)ethanone
- Packaging50mg
- Price$410
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberY1893
- Product description1-(5-(2,3-dichlorophenylthio)-4-nitrothiophen-2-yl)ethanone
- Packaging1g
- Price$621
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0017733
- Product descriptionP-005091 95.00%
- Packaging10MG
- Price$245.7
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3023
- Product descriptionP005091
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3023
- Product descriptionP005091
- Packaging10mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3023
- Product descriptionP005091
- Packaging10mM(in 1mL DMSO)
- Price$85
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3023
- Product descriptionP005091
- Packaging50mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60388
- Product descriptionP5091(P005091) ≥98%
- Packaging10mg
- Price$188
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2011
- Product descriptionP005091-P5091 99%
- Packaging10mg
- Price$104.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181077
- Product descriptionP005091(P5091) >98%
- Packaging100mg
- Price$615.4
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Acints | ACI-02006 | 1-[5-(2,3-Dichloro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone 95%+ | 1g | $427.75 | 2021-12-16 | Buy |
| Acints | ACI-02006 | 1-[5-(2,3-Dichloro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone 95%+ | 5g | $1297.75 | 2021-12-16 | Buy |
| Advanced Chemicals Intermediatesced Chemicals Intermediates | ACI-02006 | 1-[5-(2,3-Dichloro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone 95%+ | 1g | $427.75 | 2021-12-16 | Buy |
| AK Scientific | Y1893 | 1-(5-(2,3-dichlorophenylthio)-4-nitrothiophen-2-yl)ethanone | 1mg | $104 | 2021-12-16 | Buy |
| AK Scientific | Y1893 | 1-(5-(2,3-dichlorophenylthio)-4-nitrothiophen-2-yl)ethanone | 2mg | $116 | 2021-12-16 | Buy |
| AK Scientific | Y1893 | 1-(5-(2,3-dichlorophenylthio)-4-nitrothiophen-2-yl)ethanone | 10mg | $170 | 2021-12-16 | Buy |
| AK Scientific | Y1893 | 1-(5-(2,3-dichlorophenylthio)-4-nitrothiophen-2-yl)ethanone | 50mg | $410 | 2021-12-16 | Buy |
| AK Scientific | Y1893 | 1-(5-(2,3-dichlorophenylthio)-4-nitrothiophen-2-yl)ethanone | 1g | $621 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0017733 | P-005091 95.00% | 10MG | $245.7 | 2021-12-16 | Buy |
| ApexBio Technology | A3023 | P005091 | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | A3023 | P005091 | 10mg | $80 | 2021-12-16 | Buy |
| ApexBio Technology | A3023 | P005091 | 10mM(in 1mL DMSO) | $85 | 2021-12-16 | Buy |
| ApexBio Technology | A3023 | P005091 | 50mg | $250 | 2021-12-16 | Buy |
| Arctom | CFN60388 | P5091(P005091) ≥98% | 10mg | $188 | 2021-12-16 | Buy |
| Axon Medchem | Axon2011 | P005091-P5091 99% | 10mg | $104.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181077 | P005091(P5091) >98% | 100mg | $615.4 | 2021-12-16 | Buy |
Properties
Boiling point :452.4±45.0 °C(Predicted)
Density :1.60±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble10mg/mL, clear
form :powder
color :light yellow to dark yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Density :1.60±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble10mg/mL, clear
form :powder
color :light yellow to dark yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Safety Information
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| Signal word: | Danger | |||||||||||||||||||||
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Description
Ubiquitin-specific proteases (USP/UBP) remove ubiquitin from proteins, sparing them from degradation by the proteasome. USP7 is a cysteine protease associated with prostate cancer that selectively deubiquitylates HDM2, the ubiquitin E3 ligase for the tumor suppressor p53. P005091 is a trisubstituted thiophene that inhibits USP7 and the closely related USP47 (EC50s = 4.2 and 4.3 μM, respectively) with little activity against other classes of proteases, including caspases, cathepsins, calpain, metalloproteases, and serine proteases (EC50s = > 100 μM). P005091 has been shown to accelerate the degradation of the USP7 substrate HDM2 in several multiple myeloma cell lines (EC50 = 11 μM) and to inhibit the growth of HCT-116 human colorectal cancer cells (EC50 = 11 μM) synergistically with doxorubicin, etoposide, or mechlorethamine. In vivo, 10 mg/kg P005091 prolongs survival and reduces tumor growth in mice bearing human multiple myeloma and B cell leukemia xenografts.More related product prices
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