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ChemicalBook >> CAS DataBase List >> 1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone

1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone

1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone price.
  • $38 - $2839
  • Product name: 1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone
  • CAS: 314245-33-5
  • MF: C18H21FN2O
  • MW: 300.37
  • EINECS:
  • MDL Number:MFCD01917473
  • Synonyms:1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone;IU1;1-[1-(4-FLUOROPHENYL)-2,5-DIMETHYL-1H-PYRROL-3-YL]-2-(1-PYRROLIDINYL)ETHANONE;IU1;1-(1-(4-fluorophenyl)-2,5-diMethyl-1H-pyrrol-3-yl)-2-(pyrrolidin-1-yl)ethanone;Ethanone, 1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)-;IU-1 (USP14 inhibitor IU1);IU1; IU-1; IU 1;CS-1901
32 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
  • Usbiological
Package
  • 5MG
  • 25mg
  • 10mg
  • 10mM(in 1mL DMSO)
  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 1G
  • 2.5G
  • 5G
  • ManufacturerAK Scientific
  • Product numberSYN5673
  • Product descriptionIU1
  • Packaging10mg
  • Price$198
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN5673
  • Product descriptionIU1
  • Packaging100mg
  • Price$1174
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0001404
  • Product description1-[1-(4-FLUOROPHENYL)-2,5-DIMETHYL-1H-PYRROL-3-YL]-2-(1-PYRROLIDINYL)ETHANONE 95.00%
  • Packaging5MG
  • Price$401.06
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0001404
  • Product description1-[1-(4-FLUOROPHENYL)-2,5-DIMETHYL-1H-PYRROL-3-YL]-2-(1-PYRROLIDINYL)ETHANONE 95.00%
  • Packaging1G
  • Price$613
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0001404
  • Product description1-[1-(4-FLUOROPHENYL)-2,5-DIMETHYL-1H-PYRROL-3-YL]-2-(1-PYRROLIDINYL)ETHANONE 95.00%
  • Packaging2.5G
  • Price$818
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0001404
  • Product description1-[1-(4-FLUOROPHENYL)-2,5-DIMETHYL-1H-PYRROL-3-YL]-2-(1-PYRROLIDINYL)ETHANONE 95.00%
  • Packaging5G
  • Price$1018
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4002
  • Product descriptionIU1
  • Packaging10mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4002
  • Product descriptionIU1
  • Packaging10mM(in 1mL DMSO)
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4002
  • Product descriptionIU1
  • Packaging50mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4002
  • Product descriptionIU1
  • Packaging100mg
  • Price$360
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb611936
  • Product descriptionIU1 >98%
  • Packaging1g
  • Price$2839
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb611936
  • Product descriptionIU1 >98%
  • Packaging250mg
  • Price$1431.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb611936
  • Product descriptionIU1 >98%
  • Packaging100mg
  • Price$838.1
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number10617
  • Product descriptionIU1 ≥98%
  • Packaging5mg
  • Price$38
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10617
  • Product descriptionIU1 ≥98%
  • Packaging10mg
  • Price$71
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10617
  • Product descriptionIU1 ≥98%
  • Packaging50mg
  • Price$292
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific SYN5673 IU1 10mg $198 2021-12-16 Buy
AK Scientific SYN5673 IU1 100mg $1174 2021-12-16 Buy
American Custom Chemicals Corporation INB0001404 1-[1-(4-FLUOROPHENYL)-2,5-DIMETHYL-1H-PYRROL-3-YL]-2-(1-PYRROLIDINYL)ETHANONE 95.00% 5MG $401.06 2021-12-16 Buy
American Custom Chemicals Corporation INB0001404 1-[1-(4-FLUOROPHENYL)-2,5-DIMETHYL-1H-PYRROL-3-YL]-2-(1-PYRROLIDINYL)ETHANONE 95.00% 1G $613 2021-12-16 Buy
American Custom Chemicals Corporation INB0001404 1-[1-(4-FLUOROPHENYL)-2,5-DIMETHYL-1H-PYRROL-3-YL]-2-(1-PYRROLIDINYL)ETHANONE 95.00% 2.5G $818 2021-12-16 Buy
American Custom Chemicals Corporation INB0001404 1-[1-(4-FLUOROPHENYL)-2,5-DIMETHYL-1H-PYRROL-3-YL]-2-(1-PYRROLIDINYL)ETHANONE 95.00% 5G $1018 2021-12-16 Buy
ApexBio Technology A4002 IU1 10mg $50 2021-12-16 Buy
ApexBio Technology A4002 IU1 10mM(in 1mL DMSO) $60 2021-12-16 Buy
ApexBio Technology A4002 IU1 50mg $200 2021-12-16 Buy
ApexBio Technology A4002 IU1 100mg $360 2021-12-16 Buy
Biorbyt Ltd orb611936 IU1 >98% 1g $2839 2021-12-16 Buy
Biorbyt Ltd orb611936 IU1 >98% 250mg $1431.4 2021-12-16 Buy
Biorbyt Ltd orb611936 IU1 >98% 100mg $838.1 2021-12-16 Buy
Cayman Chemical 10617 IU1 ≥98% 5mg $38 2024-03-01 Buy
Cayman Chemical 10617 IU1 ≥98% 10mg $71 2024-03-01 Buy
Cayman Chemical 10617 IU1 ≥98% 50mg $292 2024-03-01 Buy

Properties

Boiling point :437.0±45.0 °C(Predicted)
Density :1.16±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
pka :8.20±0.20(Predicted)
form :powder
color :off-white to light brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Polybiquitinylation designates proteins for proteasomal degradation. USP14 is one of several deubiquitinating enzymes (DUBs) responsible for shortening proteasome-bound ubiquitin chains, which is known to antagonize the degradation of ubiquitin-protein conjugates. IU1 is a reversible, small molecule inhibitor of deubiquitination by USP14 that demonstrates an IC50 value of 4-5 μM. IU1 selectively stimulates ubiquitin-dependent protein degradation in vitro at 34 μM and in MEF cells at 50 μM. At 75 μM, IU1 reduces accumulation of oxidized proteins in HEK293 cells, alleviating cytotoxicity induced by oxidative stress.

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