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ChemicalBook >> CAS DataBase List >> PR-619

PR-619

PR-619 price.
  • $28 - $1504.5
  • Product name: PR-619
  • CAS: 2645-32-1
  • MF: C7H5N5S2
  • MW: 223.28
  • EINECS:200-256-5
  • MDL Number:MFCD00830384
  • Synonyms:PR-619;2,6-DiaMino-3,5-dithiocyanopyridine;3,5-dithiocyanatopyridine-2,6-diaMine;Thiocyanic acid, C,C'-(2,6-diamino-3,5-pyridinediyl) ester;2,6-Diamino-3,5-dithiocyanopyridine PR 619;PR 619 2,6-Diamino-3,5-dithiocyanopyridine;2,6-Diaminopyridine-3,5-bis(thiocyanate);PR-619;PR619
47 prices
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Brand
  • Acints
  • Advanced Chemicals Intermediatesced Chemicals Intermediates
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • CSNpharm
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 10
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  • 1mg
  • 5mg
  • 10mg
  • 20mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 1000mg
  • 5g
  • ManufacturerAcints
  • Product numberACI-02169
  • Product description3,5-Bis-thiocyanato-pyridine-2,6-diamine 95%+
  • Packaging25mg
  • Price$137.75
  • Updated2021-12-16
  • Buy
  • ManufacturerAcints
  • Product numberACI-02169
  • Product description3,5-Bis-thiocyanato-pyridine-2,6-diamine 95%+
  • Packaging100mg
  • Price$355.25
  • Updated2021-12-16
  • Buy
  • ManufacturerAdvanced Chemicals Intermediatesced Chemicals Intermediates
  • Product numberACI-02169
  • Product description3,5-Bis-thiocyanato-pyridine-2,6-diamine 95%+
  • Packaging100mg
  • Price$355.25
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberY1339
  • Product description3,5-dithiocyanatopyridine-2,6-diamine
  • Packaging100mg
  • Price$1116
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA244244
  • Product descriptionPR-619 98+%
  • Packaging5mg
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA244244
  • Product descriptionPR-619 98+%
  • Packaging10mg
  • Price$36
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA244244
  • Product descriptionPR-619 98+%
  • Packaging50mg
  • Price$61
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA244244
  • Product descriptionPR-619 98+%
  • Packaging100mg
  • Price$98
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA244244
  • Product descriptionPR-619 98+%
  • Packaging250mg
  • Price$147
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA244244
  • Product descriptionPR-619 98+%
  • Packaging1g
  • Price$356
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA244244
  • Product descriptionPR-619 98+%
  • Packaging5g
  • Price$920
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0004742
  • Product description2,6-DIAMINOPYRIDINE-3,5-BIS(THIOCYANATE) 95.00%
  • Packaging5MG
  • Price$505.03
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8212
  • Product descriptionPR-619
  • Packaging25mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8212
  • Product descriptionPR-619
  • Packaging100mg
  • Price$280
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS491821
  • Product descriptionPR-619 ≥98%
  • Packaging5g
  • Price$911
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS491821
  • Product descriptionPR-619 ≥98%
  • Packaging1g
  • Price$352
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Acints ACI-02169 3,5-Bis-thiocyanato-pyridine-2,6-diamine 95%+ 25mg $137.75 2021-12-16 Buy
Acints ACI-02169 3,5-Bis-thiocyanato-pyridine-2,6-diamine 95%+ 100mg $355.25 2021-12-16 Buy
Advanced Chemicals Intermediatesced Chemicals Intermediates ACI-02169 3,5-Bis-thiocyanato-pyridine-2,6-diamine 95%+ 100mg $355.25 2021-12-16 Buy
AK Scientific Y1339 3,5-dithiocyanatopyridine-2,6-diamine 100mg $1116 2021-12-16 Buy
Ambeed A244244 PR-619 98+% 5mg $28 2021-12-16 Buy
Ambeed A244244 PR-619 98+% 10mg $36 2021-12-16 Buy
Ambeed A244244 PR-619 98+% 50mg $61 2021-12-16 Buy
Ambeed A244244 PR-619 98+% 100mg $98 2021-12-16 Buy
Ambeed A244244 PR-619 98+% 250mg $147 2021-12-16 Buy
Ambeed A244244 PR-619 98+% 1g $356 2021-12-16 Buy
Ambeed A244244 PR-619 98+% 5g $920 2021-12-16 Buy
American Custom Chemicals Corporation INB0004742 2,6-DIAMINOPYRIDINE-3,5-BIS(THIOCYANATE) 95.00% 5MG $505.03 2021-12-16 Buy
ApexBio Technology A8212 PR-619 25mg $100 2021-12-16 Buy
ApexBio Technology A8212 PR-619 100mg $280 2021-12-16 Buy
Arctom AS491821 PR-619 ≥98% 5g $911 2021-12-16 Buy
Arctom AS491821 PR-619 ≥98% 1g $352 2021-12-16 Buy

Properties

Melting point :210℃
Boiling point :406.0±45.0 °C(Predicted)
Density :1.61±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble5mg/mL (clear solution)
pka :-0.19±0.50(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

PR-619 is a general inhibitor of deubiquitylating enzymes (DUBs), significantly reducing the activity of a panel of DUBs with EC50 values ranging from 5-20 μM. It is cell-permeable and reversible in its action. It is selective for DUBs over other proteases. PR-619 induces the accumulation of polyubiquitinated proteins in cells, including those not involved in the ubiquitin-proteasome system. It is used to study the role of DUBs in diverse pathways, including protein turnover and neurodegeneration.

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