NVP-BEZ 235
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- $25 - $1871.1
- Product name: NVP-BEZ 235
- CAS: 915019-65-7
- MF: C30H23N5O
- MW: 469.55
- EINECS:1312995-182-4
- MDL Number:MFCD10565944
- Synonyms:4-[2,3-Dihydro-3-Methyl-2-oxo-8-(quinolin-3-yl)-1H-iMidazo[4,5-c]quinolin-1-yl]-alpha,alpha-diMethylbenzeneacetonitrile;BEZ-235;2-methyl-2-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)propanenitrile;2-Methyl-2-[3-Methyl-2-oxo-8-(3-quinolinyl)-1-iMidazo[4,5-c]quinolinyl]propanenitrile;BEZ235 (NVP-BEZ235, Dactolisib);2-Methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl;BEZ235 NVP-BEZ235(BEZ235);Dactolisib
37 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- TRC
- Usbiological
Package
- 5mg
- 10MG
- 20mg
- 25mg
- 50mg
- 2x50mg
- 100MG
- 200mg
- 250mg
- 500mg
- 1g
- 5g
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3633-M005
- Product descriptionNVP-BEZ235 ≥98%
- Packaging5mg
- Price$25
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3633-M025
- Product descriptionNVP-BEZ235 ≥98%
- Packaging25mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1018-M050
- Product descriptionBEZ235 ≥95%
- Packaging50mg
- Price$178
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ53044
- Product descriptionDactolisib
- Packaging200mg
- Price$156
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000813
- Product descriptionNVP-BEZ235 95.00%
- Packaging10MG
- Price$739.2
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000813
- Product descriptionNVP-BEZ235 95.00%
- Packaging100MG
- Price$1871.1
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8246
- Product descriptionBEZ235(NVP-BEZ235)
- Packaging100mg
- Price$88
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8246
- Product descriptionBEZ235(NVP-BEZ235)
- Packaging500mg
- Price$280
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60056
- Product descriptionDactolisib(BEZ235) ≥98%
- Packaging20mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2630
- Product descriptionNVP-BEZ235
- Packaging10mg
- Price$39
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2630
- Product descriptionNVP-BEZ235
- Packaging25mg
- Price$59
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2630
- Product descriptionNVP-BEZ235
- Packaging100mg
- Price$79
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2630
- Product descriptionNVP-BEZ235
- Packaging250mg
- Price$149
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2630
- Product descriptionNVP-BEZ235
- Packaging1g
- Price$319
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2630
- Product descriptionNVP-BEZ235
- Packaging5g
- Price$1290
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1281
- Product descriptionBEZ235-NVP-BEZ235|Dactolisib 99%
- Packaging5mg
- Price$55
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-3633-M005 | NVP-BEZ235 ≥98% | 5mg | $25 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CR1-3633-M025 | NVP-BEZ235 ≥98% | 25mg | $65 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1018-M050 | BEZ235 ≥95% | 50mg | $178 | 2021-12-16 | Buy |
| AK Scientific | J53044 | Dactolisib | 200mg | $156 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000813 | NVP-BEZ235 95.00% | 10MG | $739.2 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000813 | NVP-BEZ235 95.00% | 100MG | $1871.1 | 2021-12-16 | Buy |
| ApexBio Technology | A8246 | BEZ235(NVP-BEZ235) | 100mg | $88 | 2021-12-16 | Buy |
| ApexBio Technology | A8246 | BEZ235(NVP-BEZ235) | 500mg | $280 | 2021-12-16 | Buy |
| Arctom | CFN60056 | Dactolisib(BEZ235) ≥98% | 20mg | $50 | 2021-12-16 | Buy |
| AvaChem | 2630 | NVP-BEZ235 | 10mg | $39 | 2021-12-16 | Buy |
| AvaChem | 2630 | NVP-BEZ235 | 25mg | $59 | 2021-12-16 | Buy |
| AvaChem | 2630 | NVP-BEZ235 | 100mg | $79 | 2021-12-16 | Buy |
| AvaChem | 2630 | NVP-BEZ235 | 250mg | $149 | 2021-12-16 | Buy |
| AvaChem | 2630 | NVP-BEZ235 | 1g | $319 | 2021-12-16 | Buy |
| AvaChem | 2630 | NVP-BEZ235 | 5g | $1290 | 2021-12-16 | Buy |
| Axon Medchem | Axon1281 | BEZ235-NVP-BEZ235|Dactolisib 99% | 5mg | $55 | 2021-12-16 | Buy |
Properties
Melting point :288-289°C
Boiling point :701.0±70.0 °C(Predicted)
Density :1.299
storage temp. :Refrigerator
solubility :Soluble in DMSO (up to 1 mg/ml with warming) or in DMF (up to 10 mg/ml, dissolves slowly, requires heating to 75?C).
pka :6.41±0.20(Predicted)
form :White powder.
color :White or off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 1 month.
CAS DataBase Reference :915019-65-7
Boiling point :701.0±70.0 °C(Predicted)
Density :1.299
storage temp. :Refrigerator
solubility :Soluble in DMSO (up to 1 mg/ml with warming) or in DMF (up to 10 mg/ml, dissolves slowly, requires heating to 75?C).
pka :6.41±0.20(Predicted)
form :White powder.
color :White or off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 1 month.
CAS DataBase Reference :915019-65-7
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Phosphatidylinositol 3-kinase (PI3K) signaling through Akt/PKB and the mammalian target of rapamycin (mTOR) controls gene expression related to cell proliferation, differentiation, and apoptosis. Increased activity of this pathway is important in many types of cancer. NVP-BEZ235 is a potent dual inhibitor of PI3K and mTOR that is well tolerated, displays disease stasis when administered orally, and enhances the efficacy of other anticancer agents when used in in vivo combination studies. It inhibits PI3K isoforms and mutants with low nanomolar IC50 values, leading to growth arrest in the G1 phase. Through its effects on PI3K, NVP-BEZ235 inhibits VEGF-induced angiogenesis. By directly blocking cell growth and indirectly inhibiting angiogenesis, it has potential in both solid tumors and in metastatic melanoma therapy.More related product prices
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