GDC-0623
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- $41 - $2500
- Product name: GDC-0623
- CAS: 1168091-68-6
- MF: C16H14FIN4O3
- MW: 456.21
- EINECS:604-604-1
- MDL Number:MFCD25976760
- Synonyms:RG 7421;5-(2-Fluoro-4-iodophenylamino)imidazo[1,5-a]pyridine-6-carboxylic acid N-(2-hydroxyethoxy)amide;GDC-0623 (5-((2-Fluoro-4-Iodophenyl)amino)-N-(2-Hydroxyethoxy)imidazo[1,5-a]pyridine-6-Carboxamide);5-(2-Fluoro-4-iodophenylamino)imidazo[1,5-a]pyridine-6-carboxylic acid N-(2-hydroxyethoxy)amide RG 7421 GDC-0623;GDC-0623;MEK inhibitor 1;G-868;5-((2-FLUORO-4-IODOPHENYL)AMINO)-N-(2-HYDROXYETHOXY)IMIDAZO[1,5-A]PYRIDINE-6-CARBOXAMIDE
17 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Apolloscientific
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- Crysdot
- DC Chemicals
- Usbiological
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 1g
- ManufacturerAK Scientific
- Product number9855DD
- Product descriptionGdc-0623
- Packaging10mg
- Price$313
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1135
- Product descriptionGDC-0623
- Packaging5mg
- Price$124
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0174
- Product descriptionGDC-0623
- Packaging5mg
- Price$189
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0174
- Product descriptionGDC-0623
- Packaging10mg
- Price$291
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0174
- Product descriptionGDC-0623
- Packaging50mg
- Price$756
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFG103137
- Product descriptionGDC 0623
- Packaging10mg
- Price$195
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFG103137
- Product descriptionGDC 0623
- Packaging50mg
- Price$682.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19479
- Product descriptionGDC-0623 ≥98%
- Packaging1mg
- Price$41
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19479
- Product descriptionGDC-0623 ≥98%
- Packaging5mg
- Price$121
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19479
- Product descriptionGDC-0623 ≥98%
- Packaging10mg
- Price$201
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19479
- Product descriptionGDC-0623 ≥98%
- Packaging25mg
- Price$302
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM151435
- Product description5-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide 98%
- Packaging100mg
- Price$439
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004427
- Product descriptionGDC-0623 98+%
- Packaging10mg
- Price$278
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004427
- Product descriptionGDC-0623 98+%
- Packaging50mg
- Price$687
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004427
- Product descriptionGDC-0623 98+%
- Packaging100mg
- Price$926
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8000
- Product descriptionGDC-0623 >98%
- Packaging1g
- Price$2500
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 9855DD | Gdc-0623 | 10mg | $313 | 2021-12-16 | Buy |
| ApexBio Technology | B1135 | GDC-0623 | 5mg | $124 | 2021-12-16 | Buy |
| Apolloscientific | BISN0174 | GDC-0623 | 5mg | $189 | 2021-12-16 | Buy |
| Apolloscientific | BISN0174 | GDC-0623 | 10mg | $291 | 2021-12-16 | Buy |
| Apolloscientific | BISN0174 | GDC-0623 | 50mg | $756 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FG103137 | GDC 0623 | 10mg | $195 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FG103137 | GDC 0623 | 50mg | $682.5 | 2021-12-16 | Buy |
| Cayman Chemical | 19479 | GDC-0623 ≥98% | 1mg | $41 | 2024-03-01 | Buy |
| Cayman Chemical | 19479 | GDC-0623 ≥98% | 5mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 19479 | GDC-0623 ≥98% | 10mg | $201 | 2024-03-01 | Buy |
| Cayman Chemical | 19479 | GDC-0623 ≥98% | 25mg | $302 | 2024-03-01 | Buy |
| Chemenu | CM151435 | 5-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide 98% | 100mg | $439 | 2021-12-16 | Buy |
| Crysdot | CD31004427 | GDC-0623 98+% | 10mg | $278 | 2021-12-16 | Buy |
| Crysdot | CD31004427 | GDC-0623 98+% | 50mg | $687 | 2021-12-16 | Buy |
| Crysdot | CD31004427 | GDC-0623 98+% | 100mg | $926 | 2021-12-16 | Buy |
| DC Chemicals | DC8000 | GDC-0623 >98% | 1g | $2500 | 2021-12-16 | Buy |
Properties
Density :1.81±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥16.85 mg/mL in DMSO; ≥2.69 mg/mL in EtOH with ultrasonic
form :solid
pka :14.17±0.10(Predicted)
color :Light yellow to gray
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥16.85 mg/mL in DMSO; ≥2.69 mg/mL in EtOH with ultrasonic
form :solid
pka :14.17±0.10(Predicted)
color :Light yellow to gray
Safety Information
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Description
GDC-0623 is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki = 0.13 nM in the presence of ATP). It inhibits the proliferation of A375 BRAF(V600E) and HCT116 KRAS(G13D)-mutant cancer cell lines with EC50 values of 7 and 42 nM, respectively. GDC-0623 inhibits ERK and BIM phosphorylation resulting in upregulation and stabilization of pro-apoptotic BIM protein in KRAS mutant and wild-type HCT116 cells and in KRAS mutant GW620 cells.Related product price
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