CEP-18770
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- $32 - $3400
- Product name: CEP-18770
- CAS: 847499-27-8
- MF: C21H28BN3O5
- MW: 413.28
- EINECS:
- MDL Number:MFCD18251439
- Synonyms:CEP-18770;[(1R)-1-[[(2S,3R)-3-Hydroxy-2-[[(6-phenylpyridin-2-yl)carbonyl]amino]-1-oxobutyl]amino]-3-methylbutyl]boronic acid;CIP 18770;CT 47098;Delanzomib;NPH 007098;CEP-18770 (DelanzoMib);DelanzoMib, Free Base, >99%
24 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- ChemScene
- DC Chemicals
- Medical Isotopes, Inc.
- TRC
- Usbiological
Package
- 10mM(in 1mL DMSO)
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 1g
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3673-M025
- Product descriptionDelanzomib[CEP-18770] ≥95%(1H-NMR)
- Packaging25mg
- Price$380
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2309AH
- Product description((R)-1-((2S,3R)-3-Hydroxy-2-(6-phenylpicolinamido)butanamido)-3-methylbutyl)boronicacid
- Packaging1mg
- Price$133
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2309AH
- Product description((R)-1-((2S,3R)-3-Hydroxy-2-(6-phenylpicolinamido)butanamido)-3-methylbutyl)boronicacid
- Packaging5mg
- Price$235
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2309AH
- Product description((R)-1-((2S,3R)-3-Hydroxy-2-(6-phenylpicolinamido)butanamido)-3-methylbutyl)boronicacid
- Packaging10mg
- Price$336
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2309AH
- Product description((R)-1-((2S,3R)-3-Hydroxy-2-(6-phenylpicolinamido)butanamido)-3-methylbutyl)boronicacid
- Packaging50mg
- Price$1112
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0013851
- Product descriptionCEP-18770 95.00%
- Packaging10MG
- Price$342.3
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4009
- Product descriptionCEP-18770
- Packaging5mg
- Price$105
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4009
- Product descriptionCEP-18770
- Packaging10mM(in 1mL DMSO)
- Price$138
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4009
- Product descriptionCEP-18770
- Packaging10mg
- Price$180
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4009
- Product descriptionCEP-18770
- Packaging50mg
- Price$640
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4009
- Product descriptionCEP-18770
- Packaging100mg
- Price$950
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number23557
- Product descriptionDelanzomib ≥95%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23557
- Product descriptionDelanzomib ≥95%
- Packaging5mg
- Price$122
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23557
- Product descriptionDelanzomib ≥95%
- Packaging10mg
- Price$214
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23557
- Product descriptionDelanzomib ≥95%
- Packaging50mg
- Price$911
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-1624
- Product descriptionDelanzomib ≥98.0%
- Packaging5mg
- Price$150
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-3673-M025 | Delanzomib[CEP-18770] ≥95%(1H-NMR) | 25mg | $380 | 2021-12-16 | Buy |
| AK Scientific | 2309AH | ((R)-1-((2S,3R)-3-Hydroxy-2-(6-phenylpicolinamido)butanamido)-3-methylbutyl)boronicacid | 1mg | $133 | 2021-12-16 | Buy |
| AK Scientific | 2309AH | ((R)-1-((2S,3R)-3-Hydroxy-2-(6-phenylpicolinamido)butanamido)-3-methylbutyl)boronicacid | 5mg | $235 | 2021-12-16 | Buy |
| AK Scientific | 2309AH | ((R)-1-((2S,3R)-3-Hydroxy-2-(6-phenylpicolinamido)butanamido)-3-methylbutyl)boronicacid | 10mg | $336 | 2021-12-16 | Buy |
| AK Scientific | 2309AH | ((R)-1-((2S,3R)-3-Hydroxy-2-(6-phenylpicolinamido)butanamido)-3-methylbutyl)boronicacid | 50mg | $1112 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0013851 | CEP-18770 95.00% | 10MG | $342.3 | 2021-12-16 | Buy |
| ApexBio Technology | A4009 | CEP-18770 | 5mg | $105 | 2021-12-16 | Buy |
| ApexBio Technology | A4009 | CEP-18770 | 10mM(in 1mL DMSO) | $138 | 2021-12-16 | Buy |
| ApexBio Technology | A4009 | CEP-18770 | 10mg | $180 | 2021-12-16 | Buy |
| ApexBio Technology | A4009 | CEP-18770 | 50mg | $640 | 2021-12-16 | Buy |
| ApexBio Technology | A4009 | CEP-18770 | 100mg | $950 | 2021-12-16 | Buy |
| Cayman Chemical | 23557 | Delanzomib ≥95% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 23557 | Delanzomib ≥95% | 5mg | $122 | 2024-03-01 | Buy |
| Cayman Chemical | 23557 | Delanzomib ≥95% | 10mg | $214 | 2024-03-01 | Buy |
| Cayman Chemical | 23557 | Delanzomib ≥95% | 50mg | $911 | 2024-03-01 | Buy |
| ChemScene | CS-1624 | Delanzomib ≥98.0% | 5mg | $150 | 2021-12-16 | Buy |
Properties
Melting point :178-190°C (dec.)
Density :1.207
storage temp. :Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility :Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
form :Solid
pka :9.67±0.43(Predicted)
color :White to Off-White
Stability :Hygroscopic
Density :1.207
storage temp. :Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility :Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
form :Solid
pka :9.67±0.43(Predicted)
color :White to Off-White
Stability :Hygroscopic
Safety Information
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Description
Delanzomib is an orally bioavailable inhibitor of chymotrypsin-like proteasome activity (IC50 = 3.8 nM in isolated human erythrocytes) that only marginally inhibits tryptic and peptidyl glutamyl proteasome activity. Delanzomib pre-treatment (20 nM) in vitro inhibits IκBα degradation, NF-κB activation, and the expression of NF-κB-regulated genes, including IκBα, XIAP, TNF-α, IL-1β, ICAM-1, and VEGF. Delanzomib induces apoptosis in multiple myeloma cell lines and inhibits proliferation in a panel of human hematologic and solid tumor cell lines (IC50s = 5.6-34.2 nM). It reduces tumor weight in an RPMI 8226 human multiple myeloma mouse xenograft model when administered intravenously at doses ranging from 1.5-4 mg/kg twice daily and leads to complete tumor regression at a chronic oral dose of 13 mg/kg. Delanzomib reduces the serum level of circulating cytokines, prevents renal tissue damage, and increases lifespan in a mouse model of fatal lupus nephritis.Related product price
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