CPI-455
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- $26 - $1700
- Product name: CPI-455
- CAS: 1628208-23-0
- MF: C16H14N4O
- MW: 278.31
- EINECS:-0
- MDL Number:MFCD29921343
- Synonyms:CPI-455;6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile;CPI 455;CPI455;CPI 455;CPI-455;CPI455;CPI-455, >98%;CPI-455(free base);Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,7-dihydro-6-(1-methylethyl)-7-oxo-5-phenyl-;CPI 455,Histone Demethylase,CPI455,CPI-455,Inhibitor,inhibit
18 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Axon Medchem
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 2x25mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number1814DY
- Product description6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile
- Packaging5mg
- Price$289
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7811
- Product description6-isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride
- Packaging5mg
- Price$85
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7811
- Product description6-isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride
- Packaging25mg
- Price$320
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2573
- Product descriptionCPI455 99%
- Packaging2x25mg
- Price$572
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number22127
- Product descriptionCPI-455 ≥98%
- Packaging1mg
- Price$26
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22127
- Product descriptionCPI-455 ≥98%
- Packaging5mg
- Price$90
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22127
- Product descriptionCPI-455 ≥98%
- Packaging10mg
- Price$153
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22127
- Product descriptionCPI-455 ≥98%
- Packaging25mg
- Price$320
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM250011
- Product description6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 97%
- Packaging250mg
- Price$281
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6133
- Product descriptionCPI-455 98.95%
- Packaging5mg
- Price$108
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6133
- Product descriptionCPI-455 98.95%
- Packaging10mg
- Price$180
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6133
- Product descriptionCPI-455 98.95%
- Packaging25mg
- Price$396
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6133
- Product descriptionCPI-455 98.95%
- Packaging50mg
- Price$720
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6133
- Product descriptionCPI-455 98.95%
- Packaging100mg
- Price$1200
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD11242980
- Product descriptionCPI-455 97%
- Packaging25mg
- Price$375
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD11242980
- Product descriptionCPI-455 97%
- Packaging50mg
- Price$681
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 1814DY | 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile | 5mg | $289 | 2021-12-16 | Buy |
| ApexBio Technology | B7811 | 6-isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride | 5mg | $85 | 2021-12-16 | Buy |
| ApexBio Technology | B7811 | 6-isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride | 25mg | $320 | 2021-12-16 | Buy |
| Axon Medchem | Axon2573 | CPI455 99% | 2x25mg | $572 | 2021-12-16 | Buy |
| Cayman Chemical | 22127 | CPI-455 ≥98% | 1mg | $26 | 2024-03-01 | Buy |
| Cayman Chemical | 22127 | CPI-455 ≥98% | 5mg | $90 | 2024-03-01 | Buy |
| Cayman Chemical | 22127 | CPI-455 ≥98% | 10mg | $153 | 2024-03-01 | Buy |
| Cayman Chemical | 22127 | CPI-455 ≥98% | 25mg | $320 | 2024-03-01 | Buy |
| Chemenu | CM250011 | 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 97% | 250mg | $281 | 2021-12-16 | Buy |
| ChemScene | CS-6133 | CPI-455 98.95% | 5mg | $108 | 2021-12-16 | Buy |
| ChemScene | CS-6133 | CPI-455 98.95% | 10mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-6133 | CPI-455 98.95% | 25mg | $396 | 2021-12-16 | Buy |
| ChemScene | CS-6133 | CPI-455 98.95% | 50mg | $720 | 2021-12-16 | Buy |
| ChemScene | CS-6133 | CPI-455 98.95% | 100mg | $1200 | 2021-12-16 | Buy |
| Crysdot | CD11242980 | CPI-455 97% | 25mg | $375 | 2021-12-16 | Buy |
| Crysdot | CD11242980 | CPI-455 97% | 50mg | $681 | 2021-12-16 | Buy |
Properties
Boiling point :488.7±55.0 °C(Predicted)
Density :1.28±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :solid
pka :-5.10±0.60(Predicted)
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Density :1.28±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :solid
pka :-5.10±0.60(Predicted)
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||||||||||||||||
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Description
CPI-455 (1628208-23-0) is a potent (IC50?= 10 nM) and selective inhibitor of the lysine demethylase KDM5 (equal inhibition of KDM5A, 5B, 5C).1?CPI-455 reduced the number of drug-tolerant persister cancer cells (DTPs) in a dose-dependent, KDM5-dependent manner in multiple cell lines treated with standard chemotherapy or targeted agents. CPI-455 synergized with 5-aza-2’-deoxycytidine (DAC) to reduce the viability of luminal breast cancer cells?in vitro.2?KDM5 demethylases have recently been shown to repress the immune response to tumors?via?suppression of STING.3Related product price
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