3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione
![3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione price.](/CAS/GIF/905854-02-6.gif)
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- $28 - $8042
- Product name: 3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione
- CAS: 905854-02-6
- MF: C23H19N3O2
- MW: 369.42
- EINECS:
- MDL Number:MFCD11977597
- Synonyms:3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione Tivantinib;3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione;Tivantinib;(-)-3(R),4(R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione, (-)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione;TIVANTINIB ARQ-197;(3R,4R)-3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-2,5-pyrrolidinedione;Tivantinib/ARQ197/ARQ-197;(3R,4R)-3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dio
32 prices
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Brand
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- TRC
- Usbiological
Package
- 1mg
- 1unit
- 5mg
- 10mg
- 20mg
- 50mg
- 100mg
- 200mg
- 250mg
- 500mg
- 1g
- ManufacturerAK Scientific
- Product numberSYN5688
- Product descriptionTivantinib
- Packaging50mg
- Price$617
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN5688
- Product descriptionTivantinib
- Packaging100mg
- Price$1053
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberY0311
- Product descriptionTivantinib
- Packaging1g
- Price$8042
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA891951
- Product descriptionTivantinib 98+%
- Packaging5mg
- Price$45
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA891951
- Product descriptionTivantinib 98+%
- Packaging10mg
- Price$67
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8325
- Product descriptionTivantinib(ARQ197)
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8325
- Product descriptionTivantinib(ARQ197)
- Packaging20mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8325
- Product descriptionTivantinib(ARQ197)
- Packaging100mg
- Price$380
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60395
- Product descriptionTivantinib(ARQ197) ≥98%
- Packaging10mg
- Price$208
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180926
- Product descriptionTivantinib (ARQ 197) >98%
- Packaging100mg
- Price$542.3
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180926
- Product descriptionTivantinib (ARQ 197) >98%
- Packaging250mg
- Price$986
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT44530
- Product descriptionTivantinib
- Packaging10mg
- Price$125
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT44530
- Product descriptionTivantinib
- Packaging50mg
- Price$437.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17135
- Product descriptionTivantinib ≥98%
- Packaging1mg
- Price$36
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17135
- Product descriptionTivantinib ≥98%
- Packaging5mg
- Price$78
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17135
- Product descriptionTivantinib ≥98%
- Packaging10mg
- Price$120
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5688 | Tivantinib | 50mg | $617 | 2021-12-16 | Buy |
| AK Scientific | SYN5688 | Tivantinib | 100mg | $1053 | 2021-12-16 | Buy |
| AK Scientific | Y0311 | Tivantinib | 1g | $8042 | 2021-12-16 | Buy |
| Ambeed | A891951 | Tivantinib 98+% | 5mg | $45 | 2021-12-16 | Buy |
| Ambeed | A891951 | Tivantinib 98+% | 10mg | $67 | 2021-12-16 | Buy |
| ApexBio Technology | A8325 | Tivantinib(ARQ197) | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | A8325 | Tivantinib(ARQ197) | 20mg | $120 | 2021-12-16 | Buy |
| ApexBio Technology | A8325 | Tivantinib(ARQ197) | 100mg | $380 | 2021-12-16 | Buy |
| Arctom | CFN60395 | Tivantinib(ARQ197) ≥98% | 10mg | $208 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180926 | Tivantinib (ARQ 197) >98% | 100mg | $542.3 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180926 | Tivantinib (ARQ 197) >98% | 250mg | $986 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT44530 | Tivantinib | 10mg | $125 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT44530 | Tivantinib | 50mg | $437.5 | 2021-12-16 | Buy |
| Cayman Chemical | 17135 | Tivantinib ≥98% | 1mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 17135 | Tivantinib ≥98% | 5mg | $78 | 2024-03-01 | Buy |
| Cayman Chemical | 17135 | Tivantinib ≥98% | 10mg | $120 | 2024-03-01 | Buy |
Properties
Boiling point :715.9±60.0 °C(Predicted)
Density :1.49
storage temp. :-20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
pka :9.28±0.70(Predicted)
form :Solid
color :Light Orange
Density :1.49
storage temp. :-20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
pka :9.28±0.70(Predicted)
form :Solid
color :Light Orange
Safety Information
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| Signal word: | Danger | |||||||||||||||||||||
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Description
MET is a proto-oncogene that encodes the hepatocyte growth factor receptor c-Met. The receptor has normal roles in morphogenesis, migration, apoptosis, and angiogenesis. Dysregulation of c-Met occurs in many types of cancer. Tivantinib is a staurosporine derivative that binds to dephosphorylated c-Met kinase, yet its mechanism of action is not known. Tivantinib has been tested in clinical studies for its ability to selectively inhibit c-Met. However, it can promote mitotic arrest and apoptosis of various human tumor cell lines (EC50s ranging from 60-600 nM) through mechanisms independent of its ability to bind c-Met. Tivantinib has been reported to bind directly to the colchicine binding site of tubulin, reducing tubulin polymerization in cells and in mouse xenograft tumors in vivo.More related product prices
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$24-2658.8
