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Analytical Chemistry

Analytical chemistry is the subject for the method and basic principle of studying and identifying of the composition, status, structure of matter as well as determination of related content. It is an important branch of chemistry subject. Analytical chemistry plays an important role in not only its own development but also in various fields related to the chemistry. We can say that all the practice of any human activity involving chemical phenomena is inseparable from analytical chemistry. Now, people have developed various kinds of different analytical methods, which can be classified based on an analysis task, analysis object, the basis of the analysis, requirement of the analysis and sample dosage.

According to the analysis tasks, it can be divided into qualitative analysis, quantitative analysis and structural analysis. Task of qualitative analysis is to identify the elements, radicals, functional groups or compounds that constituting the substances; the task of the quantitative analysis is to determine the content of the related components in the sample; the task of structural analysis is to study the molecular structure or crystal structure of the material.

(1) According to the analysis objects, it can be divided into organic and inorganic analysis; the object for the inorganic analysis is inorganic substance; the object of organic analysis is organic substance. In the inorganic analysis, it is generally required to determine what elements, ions, radicals or compounds that constitutes the sample and measure the percentage of each component; and sometimes it is also necessary for determination of the crystal structure; in the organic analysis, it not only requires the identification of the constituent elements, but also, more importantly, should do the structure analysis and functional group analysis.
(2) According to whether the analysis is based on the physical properties or chemical properties of the substance, it can be divided into instrumental analysis and chemical analysis. Depending on the specific requirements, it can be divided into routine analysis, rapid analysis and arbitration Analysis. Routine analysis refers to the general daily laboratory production analysis, also known as conventional analysis; rapid analysis is a kind of routine analysis and is mainly applied to the control of the production process, demanding the report of the results in the shortest possible time with the error generally being allowed to be greater; arbitration analysis is needed when there is controversy in the analysis results from different institute, demanding related department to conduct accurate analysis using specific method in order to determine the accuracy of the results of the original analysis.
(3) According to the amount of the sample, it can be generally divided into constant (> 0.1g), semi-micro (0.01 ~ 0.1g) and trace (1 ~ 10mg) analysis.
(4) In the inorganic qualitative chemical analysis, people generally apply semi-micro method while people generally apply constant analysis in the quantitative chemical analysis. According to the relative amounts of the analyzed components contained in the sample, it is also roughly divided into constant component analysis (> 1%), minor component analysis (0.01 to 1%) and trace components analysis (<0.01%). For the analysis of some trace amount of components contained in some kinds of complicated mixture and some substances, it is necessary to perform separation and enrichment. This produces a series of separation techniques, such as extraction, distillation, ion exchange, chromatography, sedimentation and flotation separation, these chemical separation techniques are an integral part of the analysis.

Environmental Analytical Chemistry
Environmental Analytical Chemistry is briefly referred to environmental analysis. It is a kind of subject to study the types, components of pollutants in the environment as well as how to perform qualitative and quantitative analysis on the chemical contaminants in the environment. It is a branch of environmental chemistry.

Environmental analytical chemistry emerged, developed and improved during the process of solving environmental problems. In 1950s, the public nuisance disease occurred in Japan had alerted the whole world. In order to find the cause of public nuisance disease, after experiencing as long as 11 years, later, the chemists of environmental analysis had applied light spectrum and identified that the river in Itai-itai disease area contained harmful elements such as lead, cadmium, arsenic and so on. Further by means of tracking element analysis of the soil and food in the disease area, people had found high lead and cadmium content. Later, people had further conducted spectral quantitative analysis on the body and bone of the patients in the disease area and found that the bone ashes contained alarmingly high content of zinc, lead and cadmium. To determine the causative agent, people further incorporated zinc, lead and cadmium into the food for feeding animals and conduct trace elemental analysis for animals and confirmed the serious harm of cadmium on the bone, revealing the cause of the Itai-itai disease. The development of modern science, especially the development of modern chemistry, physics, mathematics, electronics, biology, as well as the emergence of accurate, reliable, sensitive, selective, rapid, simple environmental pollution analysis technology and automation equipment, has been resulting in the maturation of environmental analytical chemistry. Environmental analytical chemistry now has penetrated into all areas of the entire environmental science subject. It is the most effective means of access to environmental information quality.
The objects of the environmental analytical chemistry research are quite complicated, including air, water, soil, sediment, minerals, waste, animals, plants, food, and human tissue. The content of chemical elements or compound to be determined in the environmental analytic chemistry is very low, with the absolute content being within the level of 10-6 to 10-12 grams.


The analysis technology in the environmental analytical chemistry is developing towards the direction of continuous automation, computerization and joint combination of various methods and instruments. Currently applied automatic analysis methods include colorimetric analysis, ion selective electrode, x-ray fluorescence spectroscopy, atomic absorption spectroscopy, polarography, gas chromatography, liquid chromatography and flow injection analysis. Laser, as the light source of analytical chemistry technique, has also been applied. Since the laser analysis has properties of high resolution, high sensitivity, long-range and short-term, the laser technology will play a pivotal role in the development of environmental analytical chemistry.

With the deepened development of environmental science, environmental analytical chemistry is often demanded for trace levels and ultra-trace-level detection and analysis, therefore, high sensitivity. Thus study of analysis methods of high sensitivity, good selectivity, rapid trace and ultra trace will become the major development direction for environmental analysis in the near future.

Qualitative Analysis of Chemistry
Qualitative analytic chemistry is the subject to identify the chemical elements and atoms groups contained in the sample. It is a branch subject of the analysis chemistry. Its purpose is to ascertain the chemical composition of the research object (specimen).
The major research content of the qualitative analytic chemistry includes:

1 the tested samples were analyzed separately. Namely take part of the sample and use exclusive reaction to detect a desire detection component.
2 systematic analysis of the samples. This means successively apply a few selective reactions for gradual separation of the ions followed by separation of each group until separating to only one substance and finally apply confirming reaction to ascertain the existence of this substance. The most famous cation system analysis method is H2S system. In recent years, due to the use of advanced equipment, qualitative analysis has also rapidly developed together with multivariate analysis and has also become an important direction for analytical chemistry.

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Structure Chemical Name CAS MF
Desfluoro Rosuvastatin Sodium Salt Desfluoro Rosuvastatin Sodium Salt 847849-66-5 C22H29N3O6S
N-Benzoyl-N-[2-(phenyl)ethyl]-N-carbamic Acid R-Quinuclidinol Ester Succinic Acid Salt N-Benzoyl-N-[2-(phenyl)ethyl]-N-carbamic Acid R-Quinuclidinol Ester Succinic Acid Salt 1798817-92-1 C27H32N2O7
Tadalafil EP IMpurity A Tadalafil EP IMpurity A
(1R,3R,4R)-3-AMino-4-hydroxy-cyclohexanecarboxylic acid ethyl ester (1R,3R,4R)-3-AMino-4-hydroxy-cyclohexanecarboxylic acid ethyl ester 1392745-70-8 C14H25NO5
(S)-3-Hydroxypiperidine (S)-3-Hydroxypiperidine 24211-55-0 C5H11NO
Aprepitant iMpurity B Aprepitant iMpurity B
Aripiprazole iMpurity 4 Aripiprazole iMpurity 4 1424857-63-5 C36H42Cl2N4O4
Aripiprazole iMpurity 4 Aripiprazole iMpurity 4 1424857-63-5 C36H42Cl2N4O4
Avanafil IMpurity 8 (R-Avanafil) Avanafil IMpurity 8 (R-Avanafil)
EzetiMibe ring-opening dehydrate iMpurity EzetiMibe ring-opening dehydrate iMpurity 1292292-63-7 C24H21F2NO3
Fondaparinux sodiuM iMpurity 1 Fondaparinux sodiuM iMpurity 1 348625-84-3 C13H21NO19S3
Pitavastatin IMpurity 4 (PP-4) Pitavastatin IMpurity 4 (PP-4) 1422058-54-5 C25H22FNO3
Pregabalin IMpurity Pregabalin IMpurity 159029-27-3 C7H18N2
Valdecoxib 3'-SulfonaMide IMpurity Valdecoxib 3'-SulfonaMide IMpurity 1373038-56-2 C16H14N2O3S
(3R,4R)-4-(2,5-Difluorophenyl)-3-Methyl-4-(1H-1,2,4-triazol-1-ylMethyl)-2-oxetanone (3R,4R)-4-(2,5-Difluorophenyl)-3-Methyl-4-(1H-1,2,4-triazol-1-ylMethyl)-2-oxetanone 483340-20-1 C13H11F2N3O2
6,7-DiMethoxy-2-(4-(tetrahydrofuran-2-carbonyl)piperazin-1-yl)quinazolin-4(1H)-one 6,7-DiMethoxy-2-(4-(tetrahydrofuran-2-carbonyl)piperazin-1-yl)quinazolin-4(1H)-one 1177261-73-2 C19H24N4O5
2-Hydroxy Atorvastatin Calcium Salt 2-Hydroxy Atorvastatin Calcium Salt 265989-46-6 C33H37CaFN2O6
13-oxo-1,4,7,10-Tetraazabicyclo[8.2.1]tridecane-4,7-diacetic Acid 13-oxo-1,4,7,10-Tetraazabicyclo[8.2.1]tridecane-4,7-diacetic Acid 229312-33-8 C13H22N4O5
1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE DIHYDROCHLORIDE 1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE DIHYDROCHLORIDE 384338-23-2 C14H22N2
Terbutaline IMpurity B Terbutaline IMpurity B 94120-05-5 C13H19NO3
Benzoic acid, 4-[(4-Methyl-1-piperazinyl)Methyl]-3-(trifluoroMethyl)- Benzoic acid, 4-[(4-Methyl-1-piperazinyl)Methyl]-3-(trifluoroMethyl)- 859282-11-4 C14H17F3N2O2
N-(5-Chloropyridin-2-yl)oxalaMic acid ethyl ester N-(5-Chloropyridin-2-yl)oxalaMic acid ethyl ester 349125-08-2 C9H9ClN2O3
5-chloro-2,3-diphenylpyrazine 5-chloro-2,3-diphenylpyrazine 41270-66-0 C16H11ClN2
rac-Clopidogrel Carboxylic Acid Hydrochloride rac-Clopidogrel Carboxylic Acid Hydrochloride 1015247-88-7 C15H15Cl2NO2S
Milnacipran IMpurity Milnacipran IMpurity 810696-16-3 C11H11NO
Terbutaline IMpurity 8 Terbutaline IMpurity 8 28924-20-1 C26H30BrNO3
Etoricoxib IMpurity Etoricoxib IMpurity 1350206-14-2 C18H16N2O2S
(1R,2R,4S)-2-[(tert-butoxycarbonyl)aMino]-4-[(diMethylaMino)carbonyl]cyclohexyl Methanesulfonate (1R,2R,4S)-2-[(tert-butoxycarbonyl)aMino]-4-[(diMethylaMino)carbonyl]cyclohexyl Methanesulfonate 929693-31-2 C15H28N2O6S
7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxaMide 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxaMide 417724-81-3 C11H10N2O3
Tegafur Impurity BCB Tegafur Impurity BCB
(R)-diethyl 2-(4-(3-chloro-4-fluorophenylaMino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-ylaMino)-2-oxo (R)-diethyl 2-(4-(3-chloro-4-fluorophenylaMino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-ylaMino)-2-oxo 618061-77-1 C24H27ClFN4O6P
((2R,3R,4R)-3-(benzoyloxy)-4-chloro-4-Methyl-5-oxotetrahydrofuran-2-yl)Methyl benzoate ((2R,3R,4R)-3-(benzoyloxy)-4-chloro-4-Methyl-5-oxotetrahydrofuran-2-yl)Methyl benzoate 1496551-65-5 C20H17ClO6
2-(4-fluorophenyl)-5-(2-Methylbenzyl)thiophene 2-(4-fluorophenyl)-5-(2-Methylbenzyl)thiophene 2005454-69-1 C18H15FS
AcetaMide, N-[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- AcetaMide, N-[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- 1429334-00-8 C16H19N3O5
PSI 7411 PSI 7411 1015073-43-4 C10H14FN2O8P
5-[[4-(Hydroxymethyl)phenoxy]methyl]-3-(1-methylethyl)-2-oxazolidinone 5-[[4-(Hydroxymethyl)phenoxy]methyl]-3-(1-methylethyl)-2-oxazolidinone 1071765-44-0 C14H19NO4
(1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol 2,3,4,6-tetrakis(2,2-dimethylpropanoate) (1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol 2,3,4,6-tetrakis(2,2-dimethylpropanoate) 1283129-18-9 C44H57FO9S
[1,4'-Bipiperidine]-1'-carboxylic acid [1,4'-Bipiperidine]-1'-carboxylic acid 1026078-50-1 C11H20N2O2
4-[[3-(1-Methylethyl)-2-oxo-5-oxazolidinyl]methoxy]benzaldehyde 4-[[3-(1-Methylethyl)-2-oxo-5-oxazolidinyl]methoxy]benzaldehyde 1173203-26-3 C14H17NO4
EMpagliflozin  iMpurity 9 EMpagliflozin iMpurity 9
570403-04-2 570403-04-2 570403-04-2 C23H24Cl3N5OS2
ibrutinib iMpurity A ibrutinib iMpurity A
Sunitinib iMpurity E Sunitinib iMpurity E
Rosuvastatin EP impurity H Rosuvastatin EP impurity H 1335110-44-5 C22H28FN3O6S
Saxagliptin Impurity 4 (Deoxy Saxagliptin) Saxagliptin Impurity 4 (Deoxy Saxagliptin)
Betamethasone EP Impurity D Betamethasone EP Impurity D 52619-05-3 C25H33FO7
Dihydropenicillin F Potassium Salt Dihydropenicillin F Potassium Salt 31447-86-6 C14H23KN2O4S
Etoricoxib Impurity 7 Etoricoxib Impurity 7 646459-39-4 C20H21N3O2S
Mupirocin Impurity D Mupirocin Impurity D C26H44O9
Pazopanib Related Compound 2 Pazopanib Related Compound 2 1226500-02-2 C26H23ClN10
Phenylephrine EP Impurity D Phenylephrine EP Impurity D 1367567-95-0 C16H19NO2
Verapamil Impurity O Verapamil Impurity O 959011-16-6 C27H38N2O4
Avibactam INT 1 Avibactam INT 1 1416134-48-9 C17H24N2O7
1,1′-[(1-Methylethyl)imino]bis[3-[4-(2-methoxyethyl)phenoxy]-2-propanol hydrochloride 1,1′-[(1-Methylethyl)imino]bis[3-[4-(2-methoxyethyl)phenoxy]-2-propanol hydrochloride 1486464-40-7 C27H42ClNO6
4-[5-({2-[(4-{5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazol-2-yl}butanoyl)oxy]ethyl}(2-chloroethyl)amino)-1-methyl-1H benzimidazol-2-yl]butanoic acid 4-[5-({2-[(4-{5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazol-2-yl}butanoyl)oxy]ethyl}(2-chloroethyl)amino)-1-methyl-1H benzimidazol-2-yl]butanoic acid 1926162-37-9 C32H42Cl4N6O4
Isavuconazole Impurity 39 Isavuconazole Impurity 39 207224-73-5 C21H18F2N4OS
Anastrozole Impurity 41 Anastrozole Impurity 41
Anastrozole Impurity 41 Anastrozole Impurity 41
Isavuconazole Impurityi45 Isavuconazole Impurityi45
Gatifloxacinacid Gatifloxacinacid 121577-32-0 C19H22FN3O4.ClH
Bisoprolol Impurity 41 Bisoprolol Impurity 41
1,4-Naphthalenedione, 2-(3-hydroxy-3,7,11,15-tetramethyl-1,6,10,14-hexadecatetraenyl)-3-methyl-, (,E,E)- (9CI) 1,4-Naphthalenedione, 2-(3-hydroxy-3,7,11,15-tetramethyl-1,6,10,14-hexadecatetraenyl)-3-methyl-, (,E,E)- (9CI) 65061-22-5 C31H40O3
Piperacilin Piperacilin
	Varenicline Impurity D Varenicline Impurity D 1002359-81-0
2-Propanone, 1-(2-hydroxypropoxy)- (9CI) 2-Propanone, 1-(2-hydroxypropoxy)- (9CI) 90817-38-2 C6H12O3
7-CHLORO-1,3DIHYDRO-5-FLUOROPHENYL-2-NITRO-METHYLENE-2H-1,4-BENZODIAZEPINE-4-OXIDE 7-CHLORO-1,3DIHYDRO-5-FLUOROPHENYL-2-NITRO-METHYLENE-2H-1,4-BENZODIAZEPINE-4-OXIDE 60656-76-0 C16H11ClFN3O3
17alpha-Hydroxytrenbolone 17alpha-Hydroxytrenbolone 80657-17-6 C18H22O2
Oseltamivir Impurity 125 Oseltamivir Impurity 125
Oseltamivir Impurity 115 Oseltamivir Impurity 115
Avatrombopag Impurity 70 Avatrombopag Impurity 70
3,4-dihydroxybutanoic acid 3,4-dihydroxybutanoic acid 1518-61-2 C4H8O4
Isocyclosporin A Isocyclosporin A 59865-16-6 C62H111N11O12
GINKGOLIC ACIDS GINKGOLIC ACIDS
R-DULOXETINE HYDROCHLORIDE R-DULOXETINE HYDROCHLORIDE 910138-96-4 C18H20ClNOS
diltiazem hydrochloride diltiazem hydrochloride 103532-27-0 C22H27ClN2O4S
(R)-Terazosin (R)-Terazosin 109351-34-0 C19H25N5O4
Methyl (1S,4R)-4-Amino-2-Cyclopentene-1-Carboxylate Methyl (1S,4R)-4-Amino-2-Cyclopentene-1-Carboxylate 138923-03-2 C7H11NO2
L-Alanine,propylester(9CI) L-Alanine,propylester(9CI) 58989-06-3 C6H13NO2
Oprinone Impurity 4 Oprinone Impurity 4
Mizolastine impurity C Mizolastine impurity C
N-hydroxyphenetidine N-hydroxyphenetidine 38246-95-6
bergaptol-O-glucopyranoside bergaptol-O-glucopyranoside 131623-13-7 C17H16O9
Rosuvastatin Impurity 172 Rosuvastatin Impurity 172
pefloxacin N-oxide pefloxacin N-oxide 85145-21-7 C17H20FN3O4
2,3-dimethyl-1,4-naphthoquinone 2,3-dimethyl-1,4-naphthoquinone 2197-57-1 C12H10O2
Softened water resin Softened water resin
(1-ETHYL-3-PIPERIDINYL)METHYLAMINE (1-ETHYL-3-PIPERIDINYL)METHYLAMINE 102459-02-9 C8H18N2
8-HYDROXY MIRTAZAPINE 8-HYDROXY MIRTAZAPINE 102335-57-9 C17H19N3O
1-[2-Amino-1-(4-benzyloxyphenyl)-ethyl]-cyclohexanol 1-[2-Amino-1-(4-benzyloxyphenyl)-ethyl]-cyclohexanol 93413-61-7 C23H31NO2
N-Deshydroxyethyl Dasatinib N-Deshydroxyethyl Dasatinib 910297-51-7 C20H22ClN7OS
N-Desethyl Sunitinib N-Desethyl Sunitinib 356068-97-8 C20H23FN4O2
6-(4-{2-[5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohexylidene]-ethylidene}-7a-methyl-octahydro-inden-1-yl)-2-methyl-heptan-2-ol 6-(4-{2-[5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohexylidene]-ethylidene}-7a-methyl-octahydro-inden-1-yl)-2-methyl-heptan-2-ol 140710-90-3 C33H58O2Si
3-Hydroxy loratadine 3-Hydroxy loratadine 183483-15-0 C22H23ClN2O3
Dehydro Lacidipine Dehydro Lacidipine 130996-24-6 C26H31NO6
Granisetron Impurity F Granisetron Impurity F 1364914-39-5 C18H24N4O
Solifenacin N-Oxide Solifenacin N-Oxide 180272-28-0 C23H26N2O3
2-chloro-N-(4-ethoxyphenyl)-4-nitrobenzamide 2-chloro-N-(4-ethoxyphenyl)-4-nitrobenzamide 328258-90-8 C15H13ClN2O4
ACETAMINOPHEN IMPURITY B ACETAMINOPHEN IMPURITY B 1693-37-4 C9H11NO2
EMpagliflozin  iMpurity 14 EMpagliflozin iMpurity 14 2137418-13-2 C23H27ClO8
4'-FLUOROCYCLOPROPANECARBOXANILIDE 4'-FLUOROCYCLOPROPANECARBOXANILIDE 2354-89-4 C10H10FNO
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