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ChemicalBook >> CAS DataBase List >> Rapamycin

Rapamycin

Rapamycin price.
  • $9 - $6160
  • Product name: Rapamycin
  • CAS: 53123-88-9
  • MF: C51H79NO13
  • MW: 914.17
  • EINECS:610-965-5
  • MDL Number:MFCD00867594
  • Synonyms:AY 22989;23,27-EPOXY-3H-PYRIDO(2,1-C)(1,4)OXAAZACYCLOHENTRIACONTINE;NSC-226080;RAPAMYCIN;RAPAMYCIN, STREPTOMYCES HYGROSCOPICUS;RPM;antibioticay22989 ;(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
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  • AccelPharmtech
  • Adipogen Life Sciences
  • AK Scientific
  • Alfa Aesar
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
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  • Arctom
  • AvaChem
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
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  • Iris Biotech GmbH
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • Tocris
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  • Usbiological
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  • 100μg
  • 1unit
  • 1mg
  • 5mg
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  • 25G
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  • 200μL
  • 10mM(in 1mL DMSO)
  • ManufacturerAccelPharmtech
  • Product numberWW1204
  • Product descriptionRapamycin 99.00%
  • Packaging5G
  • Price$660
  • Updated2021-12-16
  • Buy
  • ManufacturerAccelPharmtech
  • Product numberWW1204
  • Product descriptionRapamycin 99.00%
  • Packaging10G
  • Price$970
  • Updated2021-12-16
  • Buy
  • ManufacturerAccelPharmtech
  • Product numberWW1204
  • Product descriptionRapamycin 99.00%
  • Packaging25G
  • Price$1950
  • Updated2021-12-16
  • Buy
  • ManufacturerAccelPharmtech
  • Product numberWW1204
  • Product descriptionRapamycin 99.00%
  • Packaging100G
  • Price$6160
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CN2-0025-M005
  • Product descriptionRapamycin ≥98%
  • Packaging5mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ95892
  • Product descriptionRapamycin
  • Packaging100mg
  • Price$45
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberC593
  • Product descriptionRapamycin
  • Packaging100mg
  • Price$71
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ62473
  • Product descriptionRapamycin, 99+%
  • Packaging50mg
  • Price$136
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ62473
  • Product descriptionRapamycin, 99+%
  • Packaging100mg
  • Price$224
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ67452
  • Product descriptionRapamycin, 2.5 mg/ml in DMSO, sterile-filtered
  • Packaging1ml
  • Price$294
  • Updated2023-06-20
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ62473
  • Product descriptionRapamycin, 99+%
  • Packaging200mg
  • Price$417
  • Updated2024-03-01
  • Buy
  • ManufacturerAmbeed
  • Product numberA656002
  • Product description(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone 98%
  • Packaging100mg
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA656002
  • Product description(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone 98%
  • Packaging250mg
  • Price$47
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA656002
  • Product description(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone 98%
  • Packaging1g
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA656002
  • Product description(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone 98%
  • Packaging5g
  • Price$407
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA656002
  • Product description(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone 98%
  • Packaging25g
  • Price$1302
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AccelPharmtech WW1204 Rapamycin 99.00% 5G $660 2021-12-16 Buy
AccelPharmtech WW1204 Rapamycin 99.00% 10G $970 2021-12-16 Buy
AccelPharmtech WW1204 Rapamycin 99.00% 25G $1950 2021-12-16 Buy
AccelPharmtech WW1204 Rapamycin 99.00% 100G $6160 2021-12-16 Buy
Adipogen Life Sciences AG-CN2-0025-M005 Rapamycin ≥98% 5mg $70 2021-12-16 Buy
AK Scientific J95892 Rapamycin 100mg $45 2021-12-16 Buy
AK Scientific C593 Rapamycin 100mg $71 2021-12-16 Buy
Alfa Aesar J62473 Rapamycin, 99+% 50mg $136 2024-03-01 Buy
Alfa Aesar J62473 Rapamycin, 99+% 100mg $224 2024-03-01 Buy
Alfa Aesar J67452 Rapamycin, 2.5 mg/ml in DMSO, sterile-filtered 1ml $294 2023-06-20 Buy
Alfa Aesar J62473 Rapamycin, 99+% 200mg $417 2024-03-01 Buy
Ambeed A656002 (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone 98% 100mg $28 2021-12-16 Buy
Ambeed A656002 (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone 98% 250mg $47 2021-12-16 Buy
Ambeed A656002 (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone 98% 1g $100 2021-12-16 Buy
Ambeed A656002 (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone 98% 5g $407 2021-12-16 Buy
Ambeed A656002 (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone 98% 25g $1302 2021-12-16 Buy

Properties

Melting point :183-185°C
alpha :D25 -58.2° (methanol)
Boiling point :799.83°C (rough estimate)
Density :1.0352 (rough estimate)
vapor pressure :0.56 hPa ( 20 °C)
refractive index :1.5280 (estimate)
Flash point :87 °C
storage temp. :-20°C
solubility :ethanol: soluble2MM
pka :10.40±0.70(Predicted)
form :solution
color :colorless to yellow
Water Solubility :Soluble in DMSO at 50mg/ml or methanol at 25mg/mlSoluble in alcohol, dimethyl sulfoxide and dimethyl formamide. Insoluble in water.
Sensitive :Moisture Sensitive/Light Sensitive/Hygroscopic
Merck :14,8114
Stability :Stable for 2 years? from date of purchase as supplied.? Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
CAS DataBase Reference :53123-88-9(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Rapamycin is an immunosuppressant that is used primarily to prevent the rejection of organ and bone marrow transplant. It was first described as a potent inhibitor of IL-2 activation of lymphocytes (IC50 = 5 pM). It is now known that rapamycin specifically interacts with the cytosolic FK-binding protein 12 (FKBP12) to form a complex which inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding to mTOR Complex 1 (mTORC1). Rapamycin and other inhibitors of mTORC1 signaling show potential in treating cancer, adipogenesis, diabetes, tuberous sclerosis, and cardiovascular disease.

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