Rapamycin suppliers
Rapamycin
- CAS:
- 53123-88-9
- MF:
- C51H79NO13
- MW:
- 914.17
Suppliers by country/region
Company Type
Properties
- Melting point:
- 183-185°C
- alpha
- D25 -58.2° (methanol)
- Boiling point:
- 799.83°C (rough estimate)
- Density
- 1.0352 (rough estimate)
- vapor pressure
- 0.56 hPa ( 20 °C)
- refractive index
- 1.5280 (estimate)
- Flash point:
- 87 °C
- storage temp.
- -20°C
- solubility
- ethanol: soluble2MM
- pka
- 10.40±0.70(Predicted)
- form
- solution
- color
- colorless to yellow
- Water Solubility
- Soluble in DMSO at 50mg/ml or methanol at 25mg/mlSoluble in alcohol, dimethyl sulfoxide and dimethyl formamide. Insoluble in water.
- Sensitive
- Moisture Sensitive/Light Sensitive/Hygroscopic
- Merck
- 14,8114
- Stability:
- Stable for 2 years? from date of purchase as supplied.? Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
- CAS DataBase Reference
- 53123-88-9(CAS DataBase Reference)
Safety Information
- Symbol(GHS)
GHS08
- Signal word
- Warning
- Hazard statements
- H351-H361fd
- Precautionary statements
- P201-P202-P280-P308+P313-P405-P501
- Hazard Codes
- Xi,Xn,F
- Risk Statements
- 36/38-36-20/21/22-11
- Safety Statements
- 22-24/25-37/39-26-36/37-16
- RIDADR
- UN 1648 3 / PGII
- WGK Germany
- 2
- RTECS
- VE6250000
- Autoignition Temperature
- 301 °C
- HS Code
- 29349990
- Hazardous Substances Data
- 53123-88-9(Hazardous Substances Data)
- Toxicity
- LD50 in mice (mg/kg): 600 i.p.; >2,500 orally (Vézina)
Use
Rapamycin is a triene macrolide discovered in 1974 as a metabolite of Streptomyces hygroscopicus found in a soil obtained on Rapa Nui (Easter Island). Rapamycin displayed potent and selective antifungal activity, notably against Candida albicans. Interest in the metabolite waned until the structural relationship to the potent immunosuppressant fujimycin (Antibiotic FK506) was recognised in the mid-1980s. This recognition led to the re-discovery of rapamycin as a highly selective antitumor and immunosuppressant. Rapamycin inhibits the activity of the protein, mTOR (mammalian target of rapamycin) which functions in a signalling pathway to promote tumor growth. Rapamycin binds to a receptor protein (FKBP12). The rapamycin/FKB12 complex then binds to mTOR and prevents interaction of mTOR with target proteins in this signalling pathway.
602 supplier list of "Rapamycin"
- Product Name:Rapamycin
- Products Intro:Purity: 98% | Package: 5KG;1KG;500g;100g
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Parecoxib sodium,Paroxetine hydrochloride
- Product Name:Rapamycin
- Products Intro:Purity: 98% | Package: Gram to Kilogram Class
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Macitentan,Vortioxetine hydrobromide,Selexipag,4-(4-nitrophenyl)morpholin-3-one,polymorphism XRPD test and method validation
- Product Name:Rapamycin (Sirolimus)
- Products Intro:Purity: >98% | CustNote: BOC Sciences also provides custom synthesis services for Rapamycin (Sirolimus).
- Company Type: Reagent
- Country/Region: UNITED STATES
- Product Name:Rapamycin
- Products Intro:Purity: 99% | Package: 100KG;10KG;5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
$500.00/ 1KG
- Product Name:Rapamycin
- Products Intro:Purity: 99%|Package: 1KG;500.00;USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Oestradiol 17-heptanoate,Testosterone enanthate,GS-441524,Xylazine,Melanotan II
- Product Name:Rapamycin
- Products Intro:Purity: 95%+ | Package: 5mg;10mg;50mg;100mg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: APIs Registration,Drug Registration,Impurity Standards,Pharmaceutical Excipients,Intermediates
- Product Name:Sirolimus;Rapamycin
- Products Intro:Purity: 98%+|Package: 1g;115USD|10g;0USD|100g;0USD|1000g;0USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: SARMS,isrib,nootropic,natural compounds,peptides
$2390.00-2000.00 / 1kg
- Product Name:Rapamycin
- Products Intro:Purity: 99%|Package: 1kg;2390.00;USD|100kg;2300.00;USD|1000kg;2000.00;USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Rutile,PVA,Titanium dioxide,Pharmaceutical intermediates,Cobalt oxide