AVN-944
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- $38 - $2700
- Product name: AVN-944
- CAS: 297730-17-7
- MF: C25H27N5O5
- MW: 477.51
- EINECS:
- MDL Number:
- Synonyms:VX 944;VX944;VX-944;AVN944 (VX-944);(R)-1-cyanobutan-2-yl (S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethylcarbamate;VX 944; AVN-944;;CS-1604;[(2R)-1-cyanobutan-2-yl] N-[(1S)-1-[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]ethyl]carbamate
14 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number4211CR
- Product descriptionAvn-944
- Packaging1mg
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number21284
- Product descriptionAVN944 ≥98%
- Packaging1mg
- Price$38
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21284
- Product descriptionAVN944 ≥98%
- Packaging5mg
- Price$111
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21284
- Product descriptionAVN944 ≥98%
- Packaging10mg
- Price$184
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21284
- Product descriptionAVN944 ≥98%
- Packaging25mg
- Price$412
- Updated2024-03-01
- Buy
- ManufacturerCrysdot
- Product numberCD31002368
- Product descriptionAVN-944 98+%
- Packaging50mg
- Price$525
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31002368
- Product descriptionAVN-944 98+%
- Packaging10mg
- Price$172
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31002368
- Product descriptionAVN-944 98+%
- Packaging5mg
- Price$119
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8565
- Product descriptionAVN944 >98%
- Packaging100mg
- Price$700
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8565
- Product descriptionAVN944 >98%
- Packaging250mg
- Price$1400
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8565
- Product descriptionAVN944 >98%
- Packaging1g
- Price$2700
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML3440
- Product descriptionAVN-944 ≥98% (HPLC)
- Packaging25MG
- Price$319
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML3440
- Product descriptionAVN-944 ≥98% (HPLC)
- Packaging5MG
- Price$79
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberA794720
- Product descriptionAVN-944
- Packaging200mg
- Price$1295
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 4211CR | Avn-944 | 1mg | $140 | 2021-12-16 | Buy |
| Cayman Chemical | 21284 | AVN944 ≥98% | 1mg | $38 | 2024-03-01 | Buy |
| Cayman Chemical | 21284 | AVN944 ≥98% | 5mg | $111 | 2024-03-01 | Buy |
| Cayman Chemical | 21284 | AVN944 ≥98% | 10mg | $184 | 2024-03-01 | Buy |
| Cayman Chemical | 21284 | AVN944 ≥98% | 25mg | $412 | 2024-03-01 | Buy |
| Crysdot | CD31002368 | AVN-944 98+% | 50mg | $525 | 2021-12-16 | Buy |
| Crysdot | CD31002368 | AVN-944 98+% | 10mg | $172 | 2021-12-16 | Buy |
| Crysdot | CD31002368 | AVN-944 98+% | 5mg | $119 | 2021-12-16 | Buy |
| DC Chemicals | DC8565 | AVN944 >98% | 100mg | $700 | 2021-12-16 | Buy |
| DC Chemicals | DC8565 | AVN944 >98% | 250mg | $1400 | 2021-12-16 | Buy |
| DC Chemicals | DC8565 | AVN944 >98% | 1g | $2700 | 2021-12-16 | Buy |
| Sigma-Aldrich | SML3440 | AVN-944 ≥98% (HPLC) | 25MG | $319 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML3440 | AVN-944 ≥98% (HPLC) | 5MG | $79 | 2024-03-01 | Buy |
| TRC | A794720 | AVN-944 | 200mg | $1295 | 2021-12-16 | Buy |
Properties
Boiling point :597.4±50.0 °C(Predicted)
Density :1.277±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.52(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);62.83(Max Conc. mM) form :A crystalline solid
pka :11.38±0.46(Predicted)
color :White to off-white
Density :1.277±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.52(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);62.83(Max Conc. mM) form :A crystalline solid
pka :11.38±0.46(Predicted)
color :White to off-white
Safety Information
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Description
AVN944 is a selective, noncompetitive inhibitor of inosine-5''-monophosphate dehydrogenase (IMPDH; Ki = 6-10 nM for both human IMPDH isoforms), a rate-limiting enzyme involved in the de novo synthesis of purine nucleotides. Inhibition of IMPDH results in disruption of DNA and RNA synthesis, inhibition of cell proliferation, and the induction of apoptosis. AVN944 has been shown to inhibit the proliferation of multiple myeloma cells in vitro by inducing caspase-independent apoptosis. It is also reported to have antitumor properties in androgen-sensitive and androgen-independent prostate cancer cells in vitro.Related product price
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Suppliers and manufacturers
Zhejiang J&C Biological Technology Co.,Limited
LEAP CHEM CO., LTD.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Aladdin Scientific
Amadis Chemical Company Limited
Shanghai Boyle Chemical Co., Ltd.
Chembest Research Laboratories Limited
Haoyuan Chemexpress Co., Ltd.
![[(2R)-1-cyanobutan-2-yl] N-[(1S)-1-[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]ethyl]carbamate](https://img.chemicalbook.com/ProductImageEN/2020-1/small/000a41f5-0222-4479-966f-aed4abf409ce.png){kind=small}
