AVN-944
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2物価
選択條件：
ブランド
- Sigma-Aldrich Japan
パッケージ
- 5MG
- 25MG
- 生産者Sigma-Aldrich Japan
- 製品番號(hào)SML3440
- 製品説明 ≥98% (HPLC)
- 英語製品説明AVN-944 ≥98% (HPLC)
- 包裝単位5MG
- 価格￥11300
- 更新しました2023-06-01
- 購(gòu)入
- 生産者Sigma-Aldrich Japan
- 製品番號(hào)SML3440
- 製品説明 ≥98% (HPLC)
- 英語製品説明AVN-944 ≥98% (HPLC)
- 包裝単位25MG
- 価格￥45400
- 更新しました2023-06-01
- 購(gòu)入
| 生産者 | 製品番號(hào) | 製品説明 | 包裝単位 | 価格 | 更新時(shí)間 | 購(gòu)入 |
|---|---|---|---|---|---|---|
| Sigma-Aldrich Japan | SML3440 | ≥98% (HPLC) AVN-944 ≥98% (HPLC) |
5MG | ￥11300 | 2023-06-01 | 購(gòu)入 |
| Sigma-Aldrich Japan | SML3440 | ≥98% (HPLC) AVN-944 ≥98% (HPLC) |
25MG | ￥45400 | 2023-06-01 | 購(gòu)入 |
プロパティ
沸點(diǎn) :597.4±50.0 °C(Predicted)
比重(密度) :1.277±0.06 g/cm3(Predicted)
貯蔵溫度 :Store at -20°C
溶解性 :DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.52(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);62.83(Max Conc. mM) 外見 :A crystalline solid
酸解離定數(shù)(Pka) :11.38±0.46(Predicted)
色 :White to off-white
比重(密度) :1.277±0.06 g/cm3(Predicted)
貯蔵溫度 :Store at -20°C
溶解性 :DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.52(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);62.83(Max Conc. mM) 外見 :A crystalline solid
酸解離定數(shù)(Pka) :11.38±0.46(Predicted)
色 :White to off-white
安全情報(bào)
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説明
AVN944 is a selective, noncompetitive inhibitor of inosine-5''-monophosphate dehydrogenase (IMPDH; Ki = 6-10 nM for both human IMPDH isoforms), a rate-limiting enzyme involved in the de novo synthesis of purine nucleotides. Inhibition of IMPDH results in disruption of DNA and RNA synthesis, inhibition of cell proliferation, and the induction of apoptosis. AVN944 has been shown to inhibit the proliferation of multiple myeloma cells in vitro by inducing caspase-independent apoptosis. It is also reported to have antitumor properties in androgen-sensitive and androgen-independent prostate cancer cells in vitro.供給者とメーカー
career henan chemical co
TargetMol Chemicals Inc.
Zhejiang J&C Biological Technology Co.,Limited
LEAP CHEM CO., LTD.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Aladdin Scientific
Amadis Chemical Company Limited
Shanghai Boyle Chemical Co., Ltd.
Chembest Research Laboratories Limited
Haoyuan Chemexpress Co., Ltd.