天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Cytarabin

Cytarabine Struktur
147-94-4
CAS-Nr.
147-94-4
Bezeichnung:
Cytarabin
Englisch Name:
Cytarabine
Synonyma:
CYTOSINE ARABINOSIDE;cytarabin;DepoCyte;cytosar-u;1-β-D-Arabinofuranosylcytosine;4-AMino-1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)pyriMidin-2(1H)-one;ARA-C;Iretin;udicil;CS-193
CBNumber:
CB6305084
Summenformel:
C9H13N3O5
Molgewicht:
243.22
MOL-Datei:
147-94-4.mol

Cytarabin Eigenschaften

Schmelzpunkt:
214 °C
alpha 
D24 +153° (c = 0.5 in water)
Siedepunkt:
386.09°C (rough estimate)
Dichte
1.3686 (rough estimate)
Brechungsindex
1.5100 (estimate)
storage temp. 
2-8°C
L?slichkeit
H2O: 50 mg/mL, clear, colorless
Aggregatzustand
crystalline
pka
pKa 4.3 (Uncertain)
Farbe
Prisms from EtOH (aq)
Wasserl?slichkeit
almost transparency
maximale Wellenl?nge (λmax)
272nm(H2O)(lit.)
Merck 
14,2784
BRN 
89175
Stabilit?t:
Stable for 1 year as supplied from date of purchase. Solutions in DMSO or water may be stored at -20°C for up to 1 month.
InChIKey
UHDGCWIWMRVCDJ-STUHELBRSA-N
LogP
-1.808 (est)
CAS Datenbank
147-94-4(CAS DataBase Reference)
EPA chemische Informationen
Cytarabine (147-94-4)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn,Xi
R-S?tze: 43-63-36/37/38-20/21/22
S-S?tze: 36/37-37/39-36-26
WGK Germany  3
RTECS-Nr. HA5425000
10-23
HS Code  29349990
Giftige Stoffe Daten 147-94-4(Hazardous Substances Data)
Toxizit?t LD50 oral in rat: > 5gm/kg
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Sicherheit
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P261 Einatmen von Staub vermeiden.
P272 Kontaminierte Arbeitskleidung nicht au?erhalb des Arbeitsplatzes tragen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Cytarabin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R43:Sensibilisierung durch Hautkontakt m?glich.
R63:Kann das Kind im Mutterleib m?glicherweise sch?digen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-S?tze Betriebsanweisung:

S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Chemische Eigenschaften

A white or almost white, crystalline powder, freely soluble in water, very slightly soluble in alcohol and in methylene chloride.

Verwenden

Cytarabine USP (Cytosar)is used to treat Acute granulocytic leukemia (adults); acute lymphocytic leukemia (children); Hodgkin’s disease

Indications

Cytarabine (cytosine arabinoside, ara-C, Cytosar-U) is an analogue of the pyrimidine nucleosides cytidine and deoxycytidine. It is one of the most active agents available for the treatment of acute myelogenous leukemia. Cytarabine kills cells in the S-phase of the cycle by competitively inhibiting DNA polymerase. The drug must first be activated by pyrimidine nucleoside kinases to the triphosphate nucleotide ara-cytosine triphosphate (ara-CTP). The susceptibility of tumor cells to cytarabine is thought to be a reflection of their ability to activate the drug more rapidly (by kinases) than to inactivate it (by deaminases).

Definition

ChEBI: A pyrimidine nucleoside in which cytosine is attached to D-arabinofuranose via a beta-N1-glycosidic bond.

Allgemeine Beschreibung

Cytarabine is a pyrimidine nucleoside drug that is related toidoxuridine. This agent is primarily used as an anticanceragent for Burkitt lymphoma and myeloid and lymphaticleukemias. Cytarabine blocks the cellular utilization of deoxycytidine,hence inhibiting the replication of viral DNA.Before it becomes active, the drug is converted to monophosphates,diphosphates, and triphosphates, which block DNApolymerase and the C-2 reductase that converts cytidinediphosphate into the deoxy derivative.
The antiviral use of cytarabine is in the treatment of herpeszoster (shingles), herpetic keratitis, and viral infectionsthat resist idoxuridine. Cytarabine is usually administeredtopically. Toxicity occurs on bone marrow, the gastrointestinal(GI) tract, and the kidneys.

Air & Water Reaktionen

Water soluble.

Health Hazard

ACUTE/CHRONIC HAZARDS: Very toxic. Hazardous decomposition products. May cause irritation on contact. Teratogen. Mutagen. Central nervous system effects.

Mechanism of action

Cytarabine is rapidly metabolized in the liver, kidney, intestinal mucosa, and red blood cells and has a half-life in plasma of only 10 minutes after intravenous bolus injection. The major metabolite, uracil arabinoside (ara-U), can be detected in the blood shortly after cytarabine administration. About 80% of a given dose is excreted in the urine within 24 hours, with less than 10% appearing as cytarabine; the remainder is ara-U.When the drug is given by continuous infusion, cytarabine levels in CSF approach 40% of those in plasma.

Clinical Use

Cytarabine is used in the chemotherapy of acute myelogenous leukemia, usually in combination with an anthracycline agent, thioguanine, or both. It is less useful in acute lymphoblastic leukemia and the lymphomas and has no known activity against other tumors. It has been used intrathecally in the treatment of meningeal leukemias and lymphomas as an alternative to methotrexate.

Sicherheitsprofil

Moderate to low toxicity byingestion. Human systemic effects: allergic dermatitis,ataxia, blood changes, central nervous system effectsconjunctive irritation, degenerative brain changes, hearingacuity change, lachrymation, peripheral nervefasciculati

l?uterung methode

Purify cytarabin by recrystallisation from aqueous EtOH or a large volume of H2O (it solubility at ~20o is 5%). It has max 212 and 279nm at pH 2 and 272nm at pH 12. It is an acute leukaemic agent. [Walwick et al. Proc Chem Soc (London) 84 1959, Beilstein 25 III/IV 3669.]

Cytarabin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Cytarabin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 703)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hangzhou Measure Life Technology Co., LTD
+8613343730176
2924244016@qq.com China 83 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8810 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12835 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971
deasea125996@gmail.com China 2472 58
airuikechemical co., ltd.
+undefined86-15315557071
sales02@sdzhonghuimaterial.com China 983 58
hebei hongtan Biotechnology Co., Ltd
+86-86-1913198-3935 +8617331935328
sales03@chemcn.cn China 970 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
sales01@cooperate-pharm.com CHINA 1803 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9087 55

147-94-4(Cytarabin)Verwandte Suche:


  • cytrarabine
  • Cytosine β-D-arabinofuranoside ,98%
  • DEPOCYT (cytarabine)
  • 4-aMino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxyMethyl)oxolan-2-yl]-1,2-dihydropyriMidin-2-one
  • 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone Arabinocytidine Cytosine beta-D-Arabinofuranoside Ara-C
  • Cytarabine for Injection
  • Ara-cell
  • 1-beta-d-arabinosylcytosine
  • 4-amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidin
  • 4-amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidine
  • 4-amino-1-beta-d-arabinofuranosyl-2(1h)-pyrimidinon
  • arabitin
  • aracytidine
  • ara-cytidine
  • aracytin
  • arafcyt
  • beta-arabinosylcytosine
  • beta-d-arabinosylcytosine
  • cytarabina
  • cytarabinoside
  • cytosar
  • cytosine-beta-arabinoside
  • cytosinebeta-d-arabinoside
  • nci-c04728
  • nsc63878
  • spongocytidine
  • CYTOSINE B-D-ARABINOFURANOSIDEFREE BASE
  • Cytosinearabinosi
  • Cytarabinein-HouseStandard
  • Cytosine arabinofuranoside
  • 4-amino-1-b-D-arabinofuranosyl-2(1H)pyrimidinone, Cytosine-b-D-arabinofuranoside
  • 1-β-D-Arabinosylcytosine
  • 2(1H)-Pyrimidinone, 4-amino-1-β-D-arabinofuranosyl-
  • Arabinoside C
  • Aracytine
  • ara-Cytosine
  • CHX 3311
  • Citozar
  • Cyclocide
  • Cytosine β-D-arabinoside
  • Cytosine, 1-β-D-arabinofuranosyl- (6CI, 8CI)
  • Cytosine-1-β-arabinofuranoside
  • Cytosine-1-β-D-arabinofuranoside
  • Erpalfa
  • Iretin
  • NSC 287459
  • cytarabine,Ara-C
  • Cytarabine, 97+%
  • 2(1H)-Pyrimidinone, 4-amino-1-.beta.-D-arabinofuranosyl-
  • ARABINOCYTIDINE [4-AMINO-1-BETA-D-ARABINOFURANOSYL-2(1H)-PYRIMIDINONE]
  • Cytosine-B-D-arabinofuranoside
  • 1-β-D-ARABINOFURANOSYLCYTOSINE (CYTARABINE)
  • Cytosine 1-b-D-arabinofuranoside
  • 4-amino-1--D-arabinofuranosyl-2(1H)pyrimidinone, Cytosine--D-arabinofuranoside
  • Cytosine beta-D-arabinofuranoside Vetec(TM) reagent grade, 90%
  • (β-D-Arabinofuranosyl)cytosine Ara-C Arabinocytidine Arabinosylcytosine Cytarabine Cytosine arabinoside 4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone
  • 1-arabinofuranosylcytosine
  • 1-beta-arabinofuranosylcytosine
Copyright 2019 ? ChemicalBook. All rights reserved