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Bis[(tert-butyl)(β,3,4-trihydroxyphenethyl)ammonium]sulfat

Albuterol sulfate Struktur
51022-70-9
CAS-Nr.
51022-70-9
Bezeichnung:
Bis[(tert-butyl)(β,3,4-trihydroxyphenethyl)ammonium]sulfat
Englisch Name:
Albuterol sulfate
Synonyma:
SALBUTAMOL SULFATE;SALBUTAMOL SULPHATE;ALBUTEROL SULPHATE;Mozal;Volma;Cetsim;Respax;Loftan;Asmalin;Asmadil
CBNumber:
CB6129525
Summenformel:
C13H23NO7S
Molgewicht:
337.39
MOL-Datei:
51022-70-9.mol

Bis[(tert-butyl)(β,3,4-trihydroxyphenethyl)ammonium]sulfat Eigenschaften

Schmelzpunkt:
180 °C
Flammpunkt:
250 °C
storage temp. 
2-8°C
L?slichkeit
1 M NaOH: soluble50 mg/ml, clear to slightly hazy, yellow-green
Aggregatzustand
Solid
Farbe
White
Wasserl?slichkeit
Soluble in water and 1M sodium hydroxide (50 mg/ml).
Merck 
216
BCS Class
1
InChI
InChI=1S/C13H21NO3.H2O4S/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;1-5(2,3)4/h4-6,12,14-17H,7-8H2,1-3H3;(H2,1,2,3,4)
InChIKey
OVICLFZZVQVVFT-UHFFFAOYSA-N
SMILES
CC(C)(NCC(O)C1C=CC(O)=C(CO)C=1)C.S(O)(O)(=O)=O
CAS Datenbank
51022-70-9(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn,Xi
R-S?tze: 43-22
S-S?tze: 36/37-36
RIDADR  2811
WGK Germany  3
RTECS-Nr. ZE4400000
HS Code  29225090
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H351 Kann vermutlich Krebs verursachen. Karzinogenit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P261 Einatmen von Staub vermeiden.
P272 Kontaminierte Arbeitskleidung nicht au?erhalb des Arbeitsplatzes tragen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Bis[(tert-butyl)(β,3,4-trihydroxyphenethyl)ammonium]sulfat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R43:Sensibilisierung durch Hautkontakt m?glich.

S-S?tze Betriebsanweisung:

S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.

Beschreibung

Albuterol sulfate (Brand name: PROVENTIL® HFA) is the sulfate form of albuterol which is also known as salbutamol. It is a kind of short-acting, selective beta2-adrenergic receptor agonist being capable of opening up the medium and large airways in the lungs. It is mainly used for the treatment of bronchospasm (induced by bronchial asthma or exercise) as well as chronic obstructive pulmonary disease (COPD). Albuterol sulfate takes effects through directly biding to the beta (2)-adrenergic receptors in the lung and causing relaxation of bronchial smooth muscles. This relaxation is mediated by its effect of stimulating cAMP production through activating adenylate cyclase, further inhibiting the phosphorylation of myosin and lowering the intracellular calcium level. Albuterol sulfate can also be used to treat acute hyperkalemia of the blood.

Chemische Eigenschaften

Albuterol sulfate is a white or practically white powder, freely soluble in water and slightly soluble in ethanol.

Verwenden

Albuterol Sulfate belongs to a class of bronchodilator drugs called β2-adrenoceptor agonists. It is a prescription medicine used to treat symptoms of bronchospasm. Albuterol Sulfate may be used alone or with other medications.

Definition

ChEBI: Albuterol sulfate is an ethanolamine sulfate salt. It is functionally related to an albuterol.

Allgemeine Beschreibung

Albuterol belongs to the class of medicines known as bronchodilators. It is also called a short-acting beta-agonist (SABA).

Biologische Aktivit?t

Non-selective β -adrenergic agonist, more potent at β 2 than β 1 receptors.

Mode of action

Albuterol Sulfate is the sulfate salt of the short-acting sympathomimetic agent albuterol, a 1:1 racemic mixture of (R)-albuterol and (S)-albuterol with bronchodilator activity. Albuterol stimulates beta2-adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of ATP to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP concentrations relax bronchial smooth muscle, relieve bronchospasms, and reduce inflammatory cell mediator release, especially from mast cells. To a lesser extent albuterol stimulates beta1-adrenergic receptors, thereby increasing the force and rate of myocardial contraction.

Einzelnachweise

https://en.wikipedia.org/wiki/Salbutamol
https://www.drugbank.ca/drugs/DB01001
http://www.rxlist.com/albuterol-sulfate-drug/indications-dosage.htm

Bis[(tert-butyl)(β,3,4-trihydroxyphenethyl)ammonium]sulfat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Bis[(tert-butyl)(β,3,4-trihydroxyphenethyl)ammonium]sulfat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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51022-70-9(Bis[(tert-butyl)(β,3,4-trihydroxyphenethyl)ammonium]sulfat)Verwandte Suche:


  • 1-(4-hydroxy-3-hydroxymethylphenyl)-2-(tert-butylamino)ethanolsulfate
  • ASMAVEN SULFATE
  • COBUTOLIN
  • 2-(TERT-BUTYLAMINO)-1-(4-HYDROXY-3-HYDROXYMETHYLPHENYL)ETHANOL HEMISULFATE
  • 5-[2-(TERT-BUTYLAMINO)-1-HYDROXYETHYL]-2-HYDROXYBENZYL ALCOHOL HEMISULFATE
  • ALPHA1-[(TERT-BUTYLAMINO)METHYL]-4-HYDROXY-1,3-BENZENEDIMETHANOL HEMISULFATE SALT
  • Albuterol hemisulfate
  • Almotex
  • Anebron
  • Asmadil
  • Asmalin
  • Asmanil
  • Asmasal
  • Asmatol
  • Asmavent
  • Asmidon
  • Asmol Uni-Dose
  • Asthalin
  • Broncho-Spray
  • Broncovaleas
  • Bronter
  • Bugonol
  • Butamol
  • Buto-Asma
  • Butotal
  • Buventol
  • Cetsim
  • Dilatamol
  • Farcolin
  • Grafalin
  • Instavent
  • Libretin
  • Medolin
  • Mozal
  • Novosalmol
  • NSC 289928
  • Parasma
  • Respax
  • Salbetol
  • Salbron
  • Salbusian
  • Salbutalan
  • Salbuven
  • Salmaplon
  • Salomol
  • Sch 13949W sulfate
  • Suprasma
  • Theosal
  • Tobybron
  • Vencronyl
  • Venetlin
  • Ventelin
  • Ventilan
  • Ventimax
  • Ventodiscks
  • Ventolin Rotacaps
  • Volma
  • SULBUTAMOL SULFATE
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