Calcium(2+)-3-(acetylamino)propansulfonat
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- CAS-Nr.
- 77337-73-6
- Bezeichnung:
- Calcium(2+)-3-(acetylamino)propansulfonat
- Englisch Name:
- Acamprosate calcium
- Synonyma:
- Aotal;CaAOTA;AlcoMed;Sobriol;CaMpral EC;trans-N-Boc-1;Calcium acanate;2R)-trans-N-Boc-1;ALAMPROSATECALCIUM;ACAMPROSATE CALCIUM
- CBNumber:
- CB4310705
- Summenformel:
- C10H20CaN2O8S2
- Molgewicht:
- 400.48
- MOL-Datei:
- 77337-73-6.mol
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Calcium(2+)-3-(acetylamino)propansulfonat Eigenschaften
- Schmelzpunkt:
- >300°C
- storage temp.
- 2-8°C
- L?slichkeit
- H2O: >5mg/mL
- Aggregatzustand
- powder
- Farbe
- White to Off-White
- Wasserl?slichkeit
- Soluble in water (100mM)
- Merck
- 14,17
- InChI
- InChI=1S/2C5H11NO4S.Ca/c2*1-5(7)6-3-2-4-11(8,9)10;/h2*2-4H2,1H3,(H,6,7)(H,8,9,10);/q;;+2/p-2
- InChIKey
- BUVGWDNTAWHSKI-UHFFFAOYSA-L
- SMILES
- S([O-])(=O)(=O)CCCNC(C)=O.S([O-])(=O)(=O)CCCNC(=O)C.[Ca+2]
- CAS Datenbank
- 77337-73-6(CAS DataBase Reference)
Calcium(2+)-3-(acetylamino)propansulfonat Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Acamprosate is an acetylated derivative of the GABA analog homotaurine (tramiprosate; ). Despite its structural similarity to GABA, acamprosate does not act at GABA
A receptors but does decrease paired-pulse inhibition of GABA
A inhibitory post-synaptic currents (IPSCs) at short inter-stimulus intervals when used at a concentration of 300 μM, indicating that it may inhibit GABA
B autoreceptor-mediated inhibition of GABA release. It is an NMDA receptor modulator with antagonist or agonist effects depending on brain region, receptor subunit composition, and other factors. Acamprosate (0.26 and 0.52 mmol/kg per day, i.p.) reduces voluntary intake of ethanol in rats, an effect that can be blocked by the GABA antagonist bicuculline . Formulations containing acamprosate have been used for the maintenance of alcohol abstinence.
Chemische Eigenschaften
Acamprosate calcium is White Crystalline Solid
Verwenden
Acamprosate calcium is a synthetic amino acid and a neurotransmitter analogue that is used as an alcohol deterrent in management of alcohol dependence and abuse. Acamprosate calcium was approved for use in the therapy of alcohol dependence and abuse in the United States in 2004.
Biologische Aktivit?t
GABA receptor agonist and modulator of glutamatergic systems. Reduces alcohol consumption in animal models of alcohol addiction.
Calcium(2+)-3-(acetylamino)propansulfonat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Calcium(2+)-3-(acetylamino)propansulfonat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 227)Lieferanten
77337-73-6(Calcium(2+)-3-(acetylamino)propansulfonat)Verwandte Suche:
- calcium 3-acetamidopropane-1-sulfonate
- calcium 3-(acetylamino)propanesulphonate
- CALCIUM ACETYLHOMOTAURINE
- calcium(2+) 3-(acetylamino)propanesulphonate
- ACAMPROSATE CALCIUM
- ACAMPROSATE CALCIUMSALT
- 3-(ACETYLAMINO)-1-PROPANESULFONIC ACID CALCIUM SALT
- 3-(Acetylamino)-1-propanesulfonic Acid Calcium Salt, Calcium Acetylhomotaurine
- ALAMPROSATECALCIUM
- Bis[3-(acetylamino)-1-propanesulfonic acid]calcium salt
- CaAOTA
- Calcium acetylhomotaurinate
- 3-(Acetylamino)-1-propanesulfonicacidhemicalciumsalt
- AlcoMed
- Aotal
- CalciuM AcaMprosate
- CalciuM Bisacetyl HoMotaurine
- CalciuM N-AcetylhoMotaurinate
- CaMpral EC
- Sobriol
- Calcium 3-Acetamido-1-propanesulfonate
3-Acetamido-1-propanesulfonic Acid Calcium Salt
- 3-(Acetylamino)-1-propanesulfonic acid calcium salt (2:1)
- calcium 3-acetamido-1-propanesulfonate
- Acamprosate calcium, 98%, GABA receptor agonist and modulator of glutamatergic systems
- Acamprosate Calcium >
- N-Acetylhomotaurine Calcium
- 3-Acetamido-1-propanesulfonic Acid Calcium Salt
- Acamprosate calcium (Campral EC)
- Acamprosate-d6 Calcium Salt
- TIANFU-CHEM Acamprosate calcium
- Acamprosate Calcium (1000554)
- 2R)-trans-N-Boc-1
- trans-N-Boc-1
- Calcium acanate
- ACAMPROSATE CALCIUM USP
- Acamprosate calcium salt - Bio-X ?
- Acamprosate calcium[A6981]
- 77337-73-6
- C5H10NO4S2Ca
- 2C5H10NO4SCa
- C10H20CaN2O8S2
- C5H10Ca05NO4S
- C10H20N2O8S2Ca
- Aliphatics
- Amines
- Sulfur & Selenium Compounds
- FORMULA-405
- Neurochemicals
- Intermediates & Fine Chemicals
- Pharmaceuticals
