7-Chlor-N-methyl-5-methyl-3H-1,4-benzodiazepin-2-amin-4-oxid Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Pale Yellow Solid

Verwenden

Controlled substance (depressant). Anxiolytic. Prototype of the benzodiazepine anxiolytics

Definition

ChEBI: A benzodiazepine that is 3H-1,4-benzodiazepine 4-oxide substituted by a chloro group at position 7, a phenyl group at position 5 and a methylamino group at position 2.

Hazard

Anticonvulsant, sedative, and amnesic properties.

Stoffwechsel

Chlordiazepoxide is well absorbed after oral administration, and peak blood concentration usually is reached in approximately 4 hours. Intramuscular absorption of chlordiazepoxide, however, is slower and erratic. The half-life of chlordiazepoxide is variable but usually quite long (6–30 hours). The initial N-demethylation product, N-desmethylchloridiazepoxide, undergoes deamination to form the demoxepam, which is extensively metabolized, and less than 1% of a dose of chlordiazepoxide is excreted as demoxepam. Demoxepam can undergo four different metabolic fates. Removal of the N-oxide moiety yields the active metabolite, N-desmethyldiazepam (desoxydemoxepam). This product is a metabolite of both chlordiazepoxide and diazepam and can be hydroxylated to yield oxazepam, another active metabolite that is rapidly glucuronidated and excreted in the urine. Another possibility for metabolism of demoxepam is hydrolysis to the “opened lactam,” which is inactive. The two other metabolites of demoxepam are the products of ring A hydroxylation (9-hydroxydemoxepam) or ring C hydroxylation (4′-hydroxydemoxepam), both of which are inactive.

7-Chlor-N-methyl-5-methyl-3H-1,4-benzodiazepin-2-amin-4-oxid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

58-25-3(7-Chlor-N-methyl-5-methyl-3H-1,4-benzodiazepin-2-amin-4-oxid)Verwandte Suche:

---

• Elenium
• Helogaphen
• Ifibrium
• Kalmocaps
• Librelease
• Librinin
• Libritabs
• librium/hydrochloride/
• Limbitrol
• Menrium
• Mesural
• metaminodiazepoxide
• Methaminodiazepoxide
• Mildmen
• Multum
• Napoton
• Napton
• Psicosan
• Radepur
• Silibrin
• sonimen
• Tropium
• Viopsicol
• zeisin
• zetran
• 3H-1,4-Benzodiazepine, 2-methylamino-7-chloro-5-phenyl-4-oxide
• 3H-1,4-Benzodiazepine, 7-chloro-2-(methylamino)-5-phenyl-, 4-oxide
• 4-benzodiazepin-2-amine,7-chloro-n-methyl-5-phenyl-3h-4-oxide
• 4-benzodiazepine,7-chloro-2-(methylamino)-5-phenyl-3h-4-oxide
• 7-chlor-2-methylamino-5-phenyl-3h-1,4-benzodiazepin-4-oxid
• 7-Chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepin-4-oxide
• 7-Chloro-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-amine 4-oxide
• 7-Chloro-N-methyl-5-phenyl-3H-1,4-benzodi-azepin-2-amine4-oxide
• 7-chloro-n-methyl-5-phenyl-3h-1,4-benzodiazepin-2-amine4-oxide
• AURORA KA-6744
• CHLORODIAZEPOXIDE
• CHLORDIAZEPOXID
• CHLORDIAZEPOXIDE
• 10-chloro-3-hydroxy-n-methyl-2-phenyl-3,6-diazabicyclo[5.4.0]undeca-1,6,8,10-tetraen-5-imine
• Apo-Chlorax
• Chlordiazepoxide Base {D.D.}
• Chloroazepoxide
• Lipoxide
• Methylaminodiazepoxide
• CHLORDIAZEPOXIDE(BASE) FINE POWDER
• 7-chloro-2-(methylamino)-5-phenyl-3h-1,4-benzodiazepine-4-oxide
• CHLORDIAZEPOXIDUM
• 2-AMINO-5-CHLOROBENZOPHENONE /CHLORDIAZEPOXIDE
• 1,4-BENZODIAZEPINE,7-CHLORO-2-(METHYLAMINO)-5-PHENYL-,4-
• 7-Chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepinoxide
• 7-Chloro-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-amine 4-oxide hydrochloride
• Aids001618
• Aids-001618
• Chlordiazepoxide CIV (200 mg)
• Methanol(test Chlordiazepoxide,1.0mg/mL)
• 7-Chloro-2-(methylamino)-5-phenyl-3H-benzo[e][1,4]diazepine 4-oxide
• Chlordiazepoxide solution
• 7-cloro-2-metilamino-5-fenil-3h-1,4-benzodiazepina4-ossido