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3-(Phenylazo)-2,6-pyridindiamin-monohydrochlorid

Phenazopyridine hydrochloride  Struktur
136-40-3
CAS-Nr.
136-40-3
Bezeichnung:
3-(Phenylazo)-2,6-pyridindiamin-monohydrochlorid
Englisch Name:
Phenazopyridine hydrochloride
Synonyma:
nc150;pirid;sedural;pyrizin;urazium;uriplex;URODINE;azodyne;dolonil;giracid
CBNumber:
CB0415453
Summenformel:
C11H12ClN5
Molgewicht:
249.7
MOL-Datei:
136-40-3.mol

3-(Phenylazo)-2,6-pyridindiamin-monohydrochlorid Eigenschaften

Schmelzpunkt:
139°C
Siedepunkt:
394.6°C (rough estimate)
Dichte
1.2645 (rough estimate)
Brechungsindex
1.6110 (estimate)
storage temp. 
Sealed in dry,2-8°C
L?slichkeit
DMSO (Slightly, Heated), Methanol (Slightly, Heated)
Aggregatzustand
Liquid
Farbe
Clear to hazy colorless to yellow
Wasserl?slichkeit
0.01-0.1 g/100 mL at 20 ºC
Merck 
14,7210
Stabilit?t:
Light Sensitive
InChIKey
QQBPIHBUCMDKFG-GEEYTBSJSA-N
CAS Datenbank
136-40-3(CAS DataBase Reference)
IARC
2B (Vol. 24, Sup 7) 1987
EPA chemische Informationen
Phenazopyridine hydrochloride (136-40-3)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn,C
R-S?tze: 22-36/37/38-40-34-42/43
S-S?tze: 26-36/37-45-36/37/39-27-22
RIDADR  2811
WGK Germany  3
RTECS-Nr. US7875000
HS Code  29333990
Toxizit?t LD50 orally in rats: 403 mg/kg (Becker, Swift)
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
H351 Kann vermutlich Krebs verursachen. Karzinogenit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P261 Einatmen von Staub vermeiden.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

3-(Phenylazo)-2,6-pyridindiamin-monohydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R40:Verdacht auf krebserzeugende Wirkung.
R34:Verursacht Ver?tzungen.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S27:Beschmutzte, getr?nkte Kleidung sofort ausziehen.

Beschreibung

Phenazopyridine is an azo dye with analgesic properties. It decreases the bladder distension-induced firing rate of afferent bladder Aγ-fibers, but not C-fibers, in anesthetized rats when administered at a doses of 0.3, 1, and 3 mg/kg. Formulations containing phenazopyridine have been used as analgesics in the treatment of urinary tract infections.

Chemische Eigenschaften

Brick-Red Crystals

Verwenden

Phenazopyridine hydrochloride has been used for 50 years as an analgesic drug either alone or in combination with other drugs to reduce pain associated with urinary tract infection. An azo dye used in urinary tract infections. Also used as a local anesthetic. Exposure to phenazopyridine hydrochloride occurs during manufacture and formulation.

Definition

ChEBI: A hydrochloride obtained by combining phenazopyridine with one equivalent of hydrochloric acid. A local anesthetic that has topical analgesic effect on mucosa lining of the urinary tract. Its use is limited by problems with toxicity (primarily blood disord rs) and potential carcinogenicity.

Allgemeine Beschreibung

Brick-red microcrystals with a slight violet luster or a purple powder. Aqueous solutions are yellow to brick-red and slightly acidic; they may be stabilized by the addition of 10% glucose. Slightly bitter taste.

Air & Water Reaktionen

Dust can be explosive when suspended in air at specific concentrations. Phenazopyridine hydrochloride may be sensitive to air and light. . Very slightly water soluble.

Reaktivit?t anzeigen

Phenazopyridine hydrochloride is an azo compound. Azo, diazo, azido compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides.

Brandgefahr

Flash point data for Phenazopyridine hydrochloride are not available. Phenazopyridine hydrochloride is probably combustible.

Clinical Use

Phenazopyridine hydrochloride, 2,6-diamino-3-(phenylazopyridinehydrochloride (Pyridium), is a brick-red, finecrystalline powder. It is slightly soluble in alcohol, in chloroform,and in water.Phenazopyridine hydrochloride was formerly used asa urinary antiseptic. Although it is active in vitro againststaphylococci, streptococci, gonococci, and E. coli, it has nouseful antibacterial activity in the urine. Thus, its presentutility lies in its local analgesic effect on the mucosa of theurinary tract.
Usually, phenazopyridine is given in combination withurinary antiseptics. For example, it is available as Azo-Gantrisin, a fixed-dose combination with the sulfonamide antibacterialsulfisoxazole, and as Urobiotic, a combination withthe antibiotic oxytetracycline and the sulfonamide sulfamethizole. The drug is rapidly excreted in the urine, towhich it gives an orange-red color. Stains in fabrics may beremoved by soaking in a 0.25% solution of sodium dithionite.

Sicherheitsprofil

Confirmed carcinogen with experimental carcinogenic and tumorigenic data. A poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Human systemic effects by ingestion: somnolence, cyanosis, dlarrhea, nausea or vomiting, anuria or decreased urine volume, normocytic anemia, methemoglobinemiacarboxyhemoglobinemia, dehydration, changes in blood sodium levels. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl

Carcinogenicity

Phenazopyridine hydrochloride is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity fromstudies in experimental animals.

3-(Phenylazo)-2,6-pyridindiamin-monohydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


3-(Phenylazo)-2,6-pyridindiamin-monohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 281)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
bruce@xrdchem.cn CHINA 566 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8618959220845
sales@amoychem.com China 6383 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
Antai Fine Chemical Technology Co.,Limited
18503026267
info@antaichem.com CHINA 9636 58
SIMAGCHEM CORP
+86-13806087780
sale@simagchem.com China 17365 58

136-40-3(3-(Phenylazo)-2,6-pyridindiamin-monohydrochlorid)Verwandte Suche:


  • 2,6-diamino-3-(phenylazo)-pyridinmonohydrochloride
  • pyrizin
  • sedural
  • thiosulfil-aforte
  • urazium
  • uridinal
  • uriplex
  • urobiotic-250
  • 3-[(E)-phenyldiazenyl]pyridine-2,6-diamine hydrochloride
  • BISTERIL
  • 3-phenylazopyridine-2,6-diamine hydrochloride
  • component of Azo-Mandelamine
  • component of Azotrex
  • component of Dolonil
  • Phenazopyridine M hydrochloride
  • WLN: T6NJ BZ CNUNR & FZ & GH
  • MALLOPHENE
  • 3-PHENYLAZO-2,6-DIAMINOPYRIDINE HYDROCHLORIDE
  • 3-PHENYLAZO-2,6-DIAMINOPYRIDINE MONOHYDROCHLORIDE
  • 3-(PHENYLAZO)-2,6-PYRIDINEDIAMINE, MONOHYDROCHLORIDE
  • 3-BENZENEAZO-2,6-DIAMINOPYRIDINE MONOHYDROCHLORIDE
  • 2,6-DIAMINO-3-[PHENYLAZO]PYRIDINE HYDROCHLORIDE
  • 2,6-DIAMINO-3-(PHENYLAZO)PYRIDINE MONOHYDROCHLORIDE
  • PHENYLAZODIAMINOPYRIDINE HYDROCHLORIDE
  • PHENAZODINE
  • PHENAZOPYRIDINE HCL
  • PHENAZOPYRIDINE HYDROCHLORIDE
  • PYRIDACIL
  • PYRIDIATE
  • PYRIDIUM
  • URODINE
  • 3-(phenylazo)-2,6-pyridinediamine,hydrochloride
  • 6-pyridinediamine,3-(phenylazo)-monohydrochloride
  • azodyne
  • beta-phenylazo-alpha,alpha’-diaminopyridinehydrochloride
  • diridone
  • dolonil
  • eucistin
  • giracid
  • mallofeen
  • nc150
  • nci-c01672
  • nefrecil
  • phenazopyridiniumchloride
  • phenylazo-alpha,alpha’-diaminopyridinemonohydrochloride
  • phenylazopyridinehydrochloride
  • phenylazotablets
  • phenyl-idium
  • phenyl-idium200
  • pirid
  • pyridivite
  • pyripyridium
  • 3-PHENYLAZO-2,6-DIAMINOPYRIDINE HYDROCHLORIDE 98+%
  • 3-Phenylazo-2,6-diaminopyridineHCl
  • 3-(Phenylazo)-2,6-pyridinediamine, Monohydrochloride, Pyridium, Pyridiate, Pyridacil, Mallophene,
  • PHENAZOPYRIDINEHYDROCHLORIDE,USP
  • 3-PHENYLAZO-2,6-DIAMINOPYRIDINE HYDROCHLORIDE (PHENAZOPYRIDINE HYDROCHLORIDE)
  • 2,6-Diamino-3-(phenylazo)pyridine hydrochloride, Urodine
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