Phenforminhydrochlorid
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- CAS-Nr.
- 834-28-6
- Bezeichnung:
- Phenforminhydrochlorid
- Englisch Name:
- Phenformin hydrochloride
- Synonyma:
- 1-Phen;dbi-td;Insora;meltrol;usafvi-6;Glucopostin;PHENFORMIN HCL;Phenformine HCL;PhenforMin HCl API;phenforminhclno.9113
- CBNumber:
- CB2280910
- Summenformel:
- C10H16ClN5
- Molgewicht:
- 241.72
- MOL-Datei:
- 834-28-6.mol
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Phenforminhydrochlorid Eigenschaften
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| S-S?tze: |
36 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
DU2200000 |
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| HS Code |
29252900 |
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| Toxizit?t |
LD50 in mice (mg/kg): 19 i.v., 450 orally; in rats: 1050 orally; in guinea pigs: 47 orally, 19 s.c. (Proske) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Phenforminhydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
S-S?tze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Phenformin is an orally administered biguanide derivative with potential to lower blood glucose concentrations in patients with non-
insulin-
dependent diabetes mellitus. In general, biguanides improve insulin sensitivity and decrease insulin resistance by inhibiting complex 1 of the mitochondrial respiratory chain and inducing AMP-
activated protein kinase (AMPK)-
dependent signaling. Phenformin, however, has been withdrawn from clinical use because it also inhibits peripheral glucose oxidation and has an associated effect of inducing lactic acidosis when not metabolized sufficiently. Through AMPK activation, phenformin at 300 mg/kg exhibits anticancer activity by inhibiting the growth of MCF-7 and MDAMB231 breast cancer cell xenografts in mice.
Chemische Eigenschaften
White Crystalline Solid
Allgemeine Beschreibung
White solid or powder. Formerly used as an anti-diabetic drug. Toxic (causes lactic acidosis.
Air & Water Reaktionen
Water soluble.
Reaktivit?t anzeigen
Phenformin hydrochloride gives weakly acidic aqueous solutions. May react with strong oxidizing agents.
Brandgefahr
Flash point data for Phenformin hydrochloride are not available; however, Phenformin hydrochloride is probably combustible.
Sicherheitsprofil
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of HCl and NOx.
Phenforminhydrochlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Phenforminhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 233)Lieferanten
834-28-6(Phenforminhydrochlorid)Verwandte Suche:
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Phenforminhydrochlorid
- 1-(diaminomethylene)-2-phenethylguanidine hydrochloride
- 1-(diaminomethylene)-2-phenethyl-guanidine hydrochloride
- 1-(diaminomethylidene)-2-phenethylguanidine hydrochloride
- 1-(diaminomethylidene)-2-phenethyl-guanidine hydrochloride
- 1-Fenetilbiguanide cloridrato [Italian]
- 1-Phen
- meltrol
- n-(2-phenylethyl)-imidodicarbonimidicdiamidmonohydrochloride
- n(sup1)-beta-phenethylbiguanidehydrochloride
- n’-beta-phenethylbiguanidehydrochloride
- n-beta-phenylethylbiguanidehydrochloride
- phenforminhclno.9113
- phenoforminehydrochloride
- 1-phenethylbiguanide hydrochloride
- 1-fenetilbiguanidecloridrato
- 1-phenethyl-biguanidhydrochloride
- 1-phenethyl-biguanidmonohydrochloride
- 1-phenylaethylbiguanidhydrochlorid
- dbi-td
- usafvi-6
- Phenformine HCL
- PHENFORMINI HYDROCHLORIDE
- Insora
- N-(2-Phenylethyl)imidodicarbonimidic Diamide Hydrochloride
- BIGUANIDE,1-PHENETHYL-,MONOHYDROCHLORIDE
- PHENFORMIN HCL
- PHENFORMIN HYDROCHLORIDE
- PHENETHYLBIGUANIDE HYDROCHLORIDE
- Phenformin Hydrochloride (200 mg)
- 1-(2-Phenylethyl)biguanide hydrochloride
- Glucopostin
- Imidodicarbonimidic diamide, N-(2-phenylethyl)-, monohydrochloride
- PhenforMin HCl API
- N-(2-phenylethyl)-imidodicarbonimidic diamide, hydrochloride (1:1)
- N-(2-Phenylethyl)imidodicarbonimidic diamide monohydrochloride
- Phenformin hydrochlorid
- 1-(diaminomethylidene)-2-(2-phenylethyl)guanidine chloride
- Phenformin hydrochloride salt
- Phenformin hydrochloride solution in Methanol，1000ug/ml
- 1-Carbamimidamido-N-(2-phenylethyl)methanimidamide Hydrochloride
- PHENFORMIN HYDROCHLORIDE/834-28-6
- Phenformin hydrochloride USP/EP/BP
- Phenformin HydrochlorideQ: What is
Phenformin Hydrochloride Q: What is the CAS Number of
Phenformin Hydrochloride Q: What is the storage condition of
Phenformin Hydrochloride Q: What are the applications of
Phenformin Hydrochloride
- 1-Carbamimidamido-N-(2-phenylethyl)methanimidamide Hydrochloride[Phenethylbiguanide Hydrochloride
- 1-phenethylbiguanide hcl
- Phenformin (NSC-756501) HCl
- Amphetamine Impurity 4 (Amphetamine EP Impurity D)
- 834-28-6
- C10H15N5HClC10H16ClN5
- C10H16ClN5
- C10H15N5HCl
- 24172
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