94749-08-3
中文名稱
昔美酸沙美特羅
英文名稱
Salmeterol xinafoate
CAS
94749-08-3
分子式
C36H45NO7
MDL 編號
MFCD00897708
分子量
603.74
MOL 文件
94749-08-3.mol
更新日期
2024/12/24 16:34:45
94749-08-3 結(jié)構(gòu)式
基本信息
中文別名
苯磺阿曲庫銨葛蘭素威
2-羥甲基-4-[1-羥基-2-[6-(4-苯基丁氧基)己基氨基]乙基]苯酚 1-羥基-2-萘甲酸鹽
沙美特羅羥萘甲酸鹽
英文別名
rialSN 408
Siduomi
GR 3343G
Serevent
GR-33343G
Salmetedur
Serevent Diskus
GR 33343X XINAFOATE
SalMeterol Solution
SALMETEROL XINAFOATE
SALMETEROL XINAFONATE
salMaterol xinafoate
Salmaterol Xinafloate
JigMei acid salMeterol
SalMeterol Hydroxynapthoate
SalMeterol Xinafoate Aerosol
Salmeterol hydroxynaphthoate
Salmeterol Xinafoate (150 mg)
SalMeterol-d12 Xinafoate salt
AtracuriuM Besilate IMp. J (EP)
Salmeterol, 1-Hydroxy-2-naphthoate
(+/-) 4-HYDROXY-A1-[[[6-(4-PHENYLBUTOXY)HEXYL]AMINO]M-ETHYL]-1,3-BENZENEDIMETHANOL XINAFOATE
(±)-4-Hydroxy-alpha1-[[[6-(4-phenylbutoxy)hexy])amino]methyl]-1,3-benzenedimethanol xinafoate
4-(1-Hydroxy-2-((6-(4-phenylbutoxy)hexyl)amino)ethyl)-2-(hydroxymethyl)phenol 1-hydroxy-2-naphtho
2-(Hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol 1-hydroxy-2-naphthoate
4-(1-Hydroxy-2-((6-(4-phenylbutoxy)hexyl)aMino)ethyl)-2-(hydroxyMethyl)phenol 1-hydroxy-2-naphthoate
4-Hydroxy-alpha-({[6-(4-phenylbutoxy)hexyl]amino}methyl)-1,3-benzenedimethanol xinafoate, GR 33343X xinafoate
4-Hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]aMino]Methyl]-1,3-benzenediMethanol 1-Hydroxy-2-naphthalenecarboxylic Acid
GR 33343X xinafoate, (±) 4-Hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]m-ethyl]-1,3-benzenedimethanol xinafoate
Salmeterol Xinafoate 2-(Hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol 1-hydroxy-2-naphthoate
4-hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol with 1-hydroxy-2-naphthalenecarboxylic acid(1:1)
1,3-Benzenedimethanol, 4-hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-, 1-hydroxy-2-naphthalenecarboxylate (salt) (9CI)
1,3-Benzenedimethanol, 4-hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-, (+-)-, 1-hydroxy-2-naphthalenecarboxylate (salt)
2-Naphthalenecarboxylic acid, 1-hydroxy-, compd. with (+-)-4-hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol (1:1)
2-Naphthalenecarboxylic acid, 1-hydroxy-, compd. with 4-hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol (1:1) (9CI)
所屬類別
原料藥：骨骼肌松弛藥物理化學(xué)性質(zhì)
熔點137-138°C
儲存條件2-8°C
溶解度H2O: slightly soluble
溶解度H2O：微溶
形態(tài)solid
顏色white
Merck14,8337
InChIKeyXTZNCVSCVHTPAI-UHFFFAOYSA-N
CAS 數(shù)據(jù)庫94749-08-3(CAS DataBase Reference)
安全數(shù)據(jù)
警示詞警告
危險性描述H315-H319-H335
防范說明P280-P271
危險品標(biāo)志Xi
危險類別碼36/37/38
安全說明22-24/25-36-26
安全說明S22-S24/25
WGK Germany3
WGK Germany3
RTECS號QJ1970500
海關(guān)編碼2922504500
常見問題列表
生物活性
Salmeterol Xinafoate是一種長效的β2-adrenergic receptor激動劑，具有抗炎作用，用于哮喘癥狀和慢性阻塞性肺疾?。–OPD）癥狀的治療。靶點
| Target | Value |
| β2-adrenergic receptor |
體外研究
Salmeterol (0.001-25 μM) inhibits human T lymphocyte proliferation.
Cell Proliferation Assay
| Cell Line: | Human T lymphocytes (THP-1 cells) |
| Concentration: | 0.001, 0.01, 0.05, 0.2, 1, 5, and 25 μM |
| Incubation Time: | |
| Result: | The proliferation of Th2 cells was inhibited in a concentration dependent manner. |
體內(nèi)研究
Salmeterol (0.16 mg/kg), Formoterol (0.32 mg/kg) and combined treatment have therapeutic effects in mice with chronic obstructive pulmonary disease (COPD).
| Animal Model: | Male C57BL/6 mice (6-8 weeks old, body weight: 32-35 g) |
| Dosage: | Salmeterol (0.16 mg/kg) and/or Formoterol (0.32 mg/kg) |
| Administration: | The therapeutic efficacy of co-treatment was investigated in this model over a 56-day-long observation period. |
| Result: | COPD assessment test scores were markedly improved in mice with COPD. |