941987-60-6
中文名稱
H-151
英文名稱
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
CAS
941987-60-6
分子式
C17H17N3O
分子量
279.34
MOL 文件
941987-60-6.mol
更新日期
2024/12/22 21:55:00
941987-60-6 結構式
基本信息
中文別名
1-(4-乙基苯基)-3-(1H-吲哚-3-基)脲 英文別名
H-151H 151 NEW
STING inhibitor
STING antagonist
N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea
H151
H-151
H-151
H-151
STING ANTAGONIST
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
Urea, N-(4-ethylphenyl)-N'-1H-indol-3-yl-
物理化學性質
沸點399.9±25.0 °C(Predicted)
密度1.298±0.06 g/cm3(Predicted)
儲存條件Sealed in dry,Room Temperature
溶解度溶于 DMSO (25 mg/ml)
酸度系數(pKa)14.96±0.70(Predicted)
形態(tài)固體
顏色米白色
穩(wěn)定性可在-20°C下的DMSO中的溶液儲存長達3個月。
H-151價格(試劑級)
| 報價日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | S6652 | H-151 | 941987-60-6 | 10mM (1mL in DMSO) | 958.23元 |
| 2024/11/08 | HY-112693 | H-151 H-151 | 941987-60-6 | 5 mg | 800元 |
| 2024/11/08 | S6652 | H-151 H-151 | 941987-60-6 | 5mg | 970元 |
常見問題列表
生物活性
H-151是STING的共價拮抗劑，在人細胞和體內均具有顯著的抑制活性。靶點
| Target | Value |
|
STING
() |
體外研究
H-151 (0.02-2 μM) reduces IFNβ luciferase reporter measurements of HEK293T cells.
H-151 (0.5 μM; 2 h) inhibits the phosphorylation of TBK1 in THP-1 cells.
H-151 (1 μM; 3 h) suppresses hsSTING palmitoylation.
體內研究
H-151 (750 nmol per mouse; a single i.p.) markedly reduces systemic cytokine responses in CMA-treated mice.
H-151 (750 nmol per mouse; i.p. daily for 7 d) exhibits notable efficacy in
Trex1
?/?
mice that expressed a bioluminescent IFNβ reporter.
H-151 (750 nmol per mouse; i.p.) reaches effective systemic levels, displays a short half-life in the serum and forms an adduct to mmSTING in wild-type mice.