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6138-41-6

中文名稱 鹽酸胡蘆巴堿
英文名稱 Trigonelline hydrochloride
CAS 6138-41-6
EINECS 編號 228-119-5
分子式 C7H8ClNO2
MDL 編號 MFCD00077250
分子量 173.6
MOL 文件 6138-41-6.mol
更新日期 2024/12/18 02:50:44
6138-41-6 結構式 6138-41-6 結構式

基本信息

中文別名
N-甲基煙酸內鹽鹽酸鹽
鹽酸胡蘆巴堿
葫蘆巴堿鹽酸鹽
鹽酸葫蘆巴堿
英文別名
1-METHYLPYRIDINIUM-3-CARBOXYLATE HYDROCHLORIDE
N-METHYLNICOTINIC ACID BETAINE HYDROCHLORIDE
TIMTEC-BB SBB000182
TRIGONELLINE HCL
TRIGONELLINE HYDROCHLORIDE
TRIGONELLIN HYDROCHLORIDE
3-carboxy-1-methylpyridinium chloride
Trigonelline chloride
EINECS 228-119-5
1-Methylpyridinium-3-carboxylate hydrochloride, N-Methylnicotinic acid betaine hydrochloride
所屬類別
天然產物:生物堿

物理化學性質

外觀性狀可溶于甲醇、乙醇、DMSO等有機溶劑,來源于葫蘆巴。
熔點~260 °C (dec.)
儲存條件Inert atmosphere,Room Temperature
溶解度少許溶于甲醇、可溶于水
形態(tài)neat
顏色白色至灰白色
Merck9694
BRN3734169
穩(wěn)定性Hygroscopic
CAS 數(shù)據(jù)庫6138-41-6(CAS DataBase Reference)

應用領域

用途1
鹽酸葫蘆巴堿具有降血糖的作用。

安全數(shù)據(jù)

危險品標志Xi
危險類別碼36/37/38
安全說明S22-S24/25
WGK Germany3
海關編碼29333990
鹽酸胡蘆巴堿價格(試劑級)
報價日期產品編號產品名稱CAS號包裝價格
2024/11/08HY-N0415鹽酸胡蘆巴堿
Trigonelline chloride
6138-41-6100mg500元
2024/11/08HY-N0415鹽酸胡蘆巴堿
Trigonelline chloride
6138-41-610mM * 1mLin DMSO550元
2024/11/08HY-N0415鹽酸胡蘆巴堿
Trigonelline chloride
6138-41-6500mg800元

常見問題列表

生物活性
Trigonelline chloride 是一種大量存在于咖啡中并且具有潛在抗糖尿病活性的生物堿。Trigonelline chloride 具有抗 HSV-1,抗菌和抗真菌活性。
體外研究

It is found that Trigonelline chloride (TG) significantly rescues the morphology of the H9c2 cells. Treatment of cells with Trigonelline chloride attenuates H 2 O 2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline chloride regulates the apoptotic gene caspase-3, caspase-9 and anti-apoptotic gene Bcl-2, Bcl-XL during H 2 O 2 induced oxidative stress in H9c2 cells. For evident, flow cytometer results also confirm that Trigonelline chloride significantly reduces the H 2 O 2 induced necrosis and apoptosis in H9c2 cells. However, further increment of Trigonelline chloride concentration against H 2 O 2 can induce the necrosis and apoptosis along with H 2 O 2 .

體內研究

Trigonelline chloride decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. In nicotinamide/streptozotocin-treated rats, Trigonelline chloride significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength. Trigonelline chloride differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders, intensifying the osteoporotic changes in streptozotocin-treated rats and favorably affecting bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats.

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