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61301-33-5

中文名稱 五味子丙素
英文名稱 WUWEIZISU C
CAS 61301-33-5
分子式 C22H24O6
分子量 384.42
MOL 文件 61301-33-5.mol
更新日期 2024/12/20 18:42:32
61301-33-5 結(jié)構(gòu)式 61301-33-5 結(jié)構(gòu)式

基本信息

中文別名
五味子素C
五味子丙素對照品,
五味子丙素(標(biāo)準(zhǔn)品)
五味子丙素(五味子素C)
SCHISANDRIN C 五味子丙素
SCHISANDRIN C 五味子丙素 標(biāo)準(zhǔn)品
英文別名
WUWEIZISU C
,8-dimethyl-
SCHIZANDRIN C
(S)-(-)-Schisandrin C
WUWEIZISU C USP/EP/BP
Schisandrin C >=98% (HPLC)
Schisandrin C (Schizandrin-C
Schisandrin C (S)-(-)-Schisandrin C
cycloocta(1,2-f:3,4-f’)bis(1,3)benzodioxole6,7,8,9-tetrahydro-1,13-dimethoxy-7
(6R,7S,13aS)-5,6,7,8-Tetrahydro-13,14-dimethoxy-6,7-dimethylcycloocta[1,2-f:3,4-f']bis[1,3]benzodioxole
所屬類別
生物化工:中草藥成分

物理化學(xué)性質(zhì)

外觀性狀無色晶體,可溶于甲醇、乙醇、DMSO等有機(jī)溶劑,來源于五味子。
熔點(diǎn)122-123℃
沸點(diǎn)549.2±50.0 °C(Predicted)
密度1.232
溶解度DMSO : 8.33 mg/mL (21.67 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
形態(tài)粉末
顏色白色
LogP5.623 (est)

安全數(shù)據(jù)

危險(xiǎn)性符號(GHS)GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS09
警示詞警告
危險(xiǎn)性描述H302-H410

應(yīng)用領(lǐng)域

用途1
五味子丙素具有拮抗 、抗癌、抗?jié)儭⒈8蔚淖饔谩?/span>

常見問題列表

生物活性
Schisandrin C (Schizandrin-C) 是從五味子中分離得到的一種植物化學(xué)木脂素 (lignan)。Schisandrin C 具有多種生物活性,包括抗癌、抗炎和抗氧化作用。Schisandrin C 可用于癌癥、阿爾茨海默病、肝病的研究。Schisandrin C 誘導(dǎo)細(xì)胞凋亡 (apoptosis)。
體外研究

Schisandrin C (25-100 μM; 48 hours) down-regulates expression levels of Bcl-2, Bcl-xL and a concomitant degradation of poly(ADP-ribose) polymerase (PARP). It also activates caspase-3 and -9 in U937 cells.Schisandrin C (25-100 μM; 48 hours) induces apoptosis in a dose-dependent manner. And the fragmentation of genomic DNA is also increased in U937 cells.Schisandrin C (25-100 μM; 72 hours) induces G1 arrest, it down-regulates cyclin D1, cyclin E, cyclin-dependent kinase (Cdk) 4 and E2Fs expression, and also exhibits inhibition of pRB, and up-regulation of the Cdk inhibitor p21(WAF1/CIP1).

Western Blot Analysis

Cell Line: U937 cells
Concentration: 25 μM,50 μM,100 μM
Incubation Time: 48 hours
Result: Decreased the expression of apoptosis related proteins.

Apoptosis Analysis

Cell Line: U937 cells
Concentration: 25 μM,50 μM,100 μM
Incubation Time: 48 hours
Result: Induced cell apoptosis.

Cell Cycle Analysis

Cell Line: U937 cells
Concentration: 25 μM,50 μM,100 μM
Incubation Time: 48 hours
Result: Induced growth inhibition and G1 arrest of U937 cells.
體內(nèi)研究

Schisandrin C (lateral ventricle injection (i.c.v.); 15-150 μg/kg; 5 days) reduces Aβ1-42-induced memory deficits in the Y-maze test. Neurons in the hippocampus of SCH-C (15 μg/kg)-treated group returned to normal level, and and SCH-C group (150 μg/kg) has slight neuroprotective effects Aβ1-42-induced group. SCH-C (15 μg/kg) recoveres the activities of SOD and GSHPx and the ratios of GSH, decreases the levels of ChEtotal in the brain of the Aβ1–42-induced amnesic mice simultaneously.

Animal Model: Aβ1-42-induced Alzheimer’s disease mice
Dosage: 15-150 μg/kg
Administration: Lateral ventricle injection (i.c.v.); 15-150 μg/kg; 5 days
Result: Exhibited potent neuroprotective effects linking to anti-ChEtotal activities and anti-oxidative mechanisms in Aβ1-42-induced amnestic mice.
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