2756-87-8
2756-87-8 結(jié)構(gòu)式
基本信息
Fumaric acid monomethyl ester, Methyl hydrogen fumarate
(E)-2-Butenedioic acid hydrogen 1-methyl ester
Fumaric acid hydrogen 1-methyl ester
Monomethyl trans-ethylene-1,2-dicarboxylate
物理化學(xué)性質(zhì)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/11 | XW275687803 | 富馬酸單甲酯 | 2756-87-8 | 25G | 33元 |
| 2024/11/11 | XW275687802 | 富馬酸單甲酯 | 2756-87-8 | 5G | 32元 |
| 2024/11/11 | XW275687801 | 富馬酸單甲酯 | 2756-87-8 | 1G | 29元 |
常見問題列表
| Target | Value |
|
GPR109A
() |
Monomethyl fumarate completely inhibits forskolin induced cAMP synthesis with an IC
50
of 70 nM. Monomethyl fumarate induces a dose-dependent Ca
2+
signal in GPR109A transfected cells with an EC
50
of 9.4 μM.
Monomethyl fumarate (25 μM; 24?hours) attenuates 7β-OHC-induced cytotoxicity: cell growth inhibition; decreased cell viability; mitochondrial dysfunction; and cell death induction.
A single dose of Monomethyl fumarate (50-100 mg/kg; IP) before light exposure prevents these morphologic changes (bright light exposure induced photoreceptor death) in a dose-dependent manner.
Monomethyl fumarate (100 mg/kg) reduces retinal inflammation and oxidative stress. Monomethyl fumarate significantly suppresses light-induced retinopathy (LIR) upregulated genes in the NFkB pathway including: Nlrp3, Casp1, Il-1β, and Tnf-α.
| Animal Model: | Albino BALB/c mice (male, 6 weeks old) |
| Dosage: | 50, 65, 75, 100 mg/kg |
| Administration: | IP |
| Result: | Prevented these morphologic changes (bright light exposure induced photoreceptor death) in a dose-dependent manner. |