1617-53-4
中文名稱(chēng)
穗花杉雙黃酮
英文名稱(chēng)
Amentoflavone
CAS
1617-53-4
分子式
C30H18O10
MDL 編號(hào)
MFCD00017470
分子量
538.46
MOL 文件
1617-53-4.mol
更新日期
2024/12/24 14:12:49
1617-53-4 結(jié)構(gòu)式
基本信息
中文別名
穗花杉雙黃酮穗花雙黃酮
英文別名
3',8''-BIAPIGENIN4',4''',5,5'',7,7''-HEXAHYDROXY-3''',8-BIFLAVONE
AMENTOFLAVONE
DIDEMETHYL-GINKGETIN
I3,II8 BIAPIGENIN
amenthoflavone
AMENTOFLACONE
AMENTOFLAVONE(SH)
AMENTOFLAVONE WITH HPLC
AMENTOFLAVONE hplc
2-(4-Hydroxyphenyl)-5,7-dihydroxy-8-[2-hydroxy-5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)phenyl]-4H-1-benzopyran-4-one
4',5,7-Trihydroxy-8-[2-hydroxy-5-(4-oxo-5,7-dihydroxy-4H-1-benzopyran-2-yl)phenyl]flavone
5,7,4',5'',7'',4'''-Hexahydroxy-3',8''-biflavone
8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
所屬類(lèi)別
天然產(chǎn)物：黃酮類(lèi)化合物物理化學(xué)性質(zhì)
外觀性狀黃色結(jié)晶粉末，易溶于甲醇，幾乎不溶于乙醚，來(lái)源于卷柏，杉木枝葉。
熔點(diǎn)>300°C (dec.)
沸點(diǎn)910.5±65.0 °C(Predicted)
密度1.656±0.06 g/cm3(Predicted)
儲(chǔ)存條件2-8°C
溶解度DMSO（輕微）、甲醇（輕微、加熱）、吡啶（輕微）
酸度系數(shù)(pKa)6.01±0.40(Predicted)
形態(tài)neat
顏色黃色
BRN380244
InChIKeyYUSWMAULDXZHPY-UHFFFAOYSA-N
LogP3.492 (est)
CAS 數(shù)據(jù)庫(kù)1617-53-4(CAS DataBase Reference)
應(yīng)用領(lǐng)域
用途1
一種具有抗病毒和抗炎作用的生物類(lèi)黃酮。Amentoflavone is a bioflavonoid that has anti-viral and anti-inflammatory properties. The compound has been observed to inhibit the expression of INOS, LPS-induced activation of NFκB p50 (NF-κ B), translocation of p65 by LPS and block IKKα(I-κ B α) degradation in macrophages. Amentoflavone has been shown to up-regulate PPAR-γ and block the induction of COX-2. It is a negative modulator of the GABAA receptor at the benzodiazepine binding site. The compound has demonstrated anti-viral activity against respiratory syncytial virus (RSV), with an IC50 of 5.5 μg/ml. Amentoflavone has also pronounced inhibition at an IC50 = 14.9 +/- 1.9 nM of benzodiazepine binding in vitro.用途2
穗花杉雙黃酮具有抗腫瘤、清除自由基、舒張血管、降血糖的作用。