22368-21-4
22368-21-4 結構式
基本信息
歐帕提林
異澤蘭黃素
異澤蘭黃素對照品,
異澤蘭黃素, BR
艾葉浸膏 棕矢車菊素
異澤蘭黃素(標準品)
異澤蘭黃素(≥95%)
異澤蘭黃素(澤蘭林素)
EUPATILIN 異澤蘭黃素(≥95%)
NSC 122413
Eupatilin, BR
Eupatilin 22368-21-4
5,7-Dihydroxy-3',4',6-trimethoxyflavone
2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one
2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one
2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 2-(3,4-diMethoxyphenyl)-5,7-dihydroxy-6-Methoxy-
Eupatilin 2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one
物理化學性質
常見問題列表
2.抑制腫瘤生長。
3.澤蘭林素可用于治療胃潰瘍和鎮(zhèn)痙。
4.調控血糖含量。
5.抗誘變因素的小生能。
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PPARα
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Eupatilin is a PPARα agonist. Eupatilin (10, 30, 100 μM) suppresses IL-4 expression and degranulation in RBL-2H3 cells. Eupatilin (50-100 μM) slightly reduces cell viability of HaCaT cells. Eupatilin (10, 30, 50, 100 μM) increases PPARα transactivation and expression in HaCaT cells. Eupatilin (10, 30, 50 μM) also suppresses TNFα-induced MMP-2/-9 expression in HaCaT cells. Furthermore, Eupatilin inhibits TNFα-induced p65 translocation, IκBα Phosphorylation, AP-1 and MAPK signaling via PPARα. Eupatilin (10-50 μM) shows no cytotoxic effects on ARPE19 cells. Eupatilin (10, 25, 50 μM) elevates cell viability from oxidative stress, and inhibits H 2 O 2 -induced ROS production in ARPE19 cells. Moreover, Eupatilin (50 μM) inbibits H 2 O 2 -induced cells apoptosis and promotes the activation of PI3K/Akt pathway in RPE cells.
Eupatilin (1.5% or 3.0%) restores PPARα mRNA expression, and improves atopic dermatitis (AD)-like symptoms in oxazolone-induced Balb/c mice. Eupatilin causes significant decrease in serum IgE, IL-4 levels, oxazolone-induced TNFα, IFNγ, IL-1β, TSLP, IL-33 and IL-25 mRNA expression in oxazolone-induced mice. Eupatilin also increases filaggrin and loricrin mRNA expression in oxazolone-induced mice.