| Identification | More | [Name]
Bromisoval | [CAS]
496-67-3 | [Synonyms]
1-(2-BROMOISOVALERYL)UREA
A-(BROMOISOVALERYL)UREA
ALPHA(BROMOISOVALERYL)UREA
BROMISOVAL
BROMOISOVALERYLUREA
BROMO-ISO-VALERYLUREA (ALPHA)
BROMOVALERYLUREA
LABOTEST-BB LT00134620
RARECHEM AX KI 5046
(2-bromo-3-methylbutyryl)-ure
(alpha-Bromo-.beta,beta.-dimethylpropanoyl)urea
(alpha-Bromoisovaleroyl)urea
2-Bromisovalerylmocovina
2-Bromo-3-Methylbutyrylurea
2-Bromo-3-methylbutyrylurea deaux Base GP
2-Bromo-isovaleryl urea
2-Monobromoisovalerylurea
Abroval
Alluval
alpha-Bromisovalerylurea | [EINECS(EC#)]
207-825-7 | [Molecular Formula]
C6H11BrN2O2 | [MDL Number]
MFCD00047873 | [Molecular Weight]
223.07 | [MOL File]
496-67-3.mol |
| Safety Data | Back Directory | [RTECS ]
YS3150000 | [HS Code ]
2924.19.8000 | [Safety Profile]
Moderately toxic by
ingestion. Human systemic effects by
ingestion: nausea or vomiting, and coma. A
sedative and hypnotic agent. When heated
to decomposition it emits very toxic fumes
of Brand NOx | [Toxicity]
LD50 in male mice (mmoles/kg): 3.25 i.p. (Mrongovius) |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Originator]
Bromisovalum,Linhai Duqiao Fine
Chemical Factory | [Uses]
2-Bromo-3-methylbutyrylurea is a hypnotic and sedative drug marketed over the counter in Asian under various brand names. | [Definition]
ChEBI: An N-acylurea that is urea in which one of the hydrogens is replaced by a 2-bromo-3-methybutanoyl group. | [Manufacturing Process]
A mixture of 2 kg 2-bromoisovalerylbromide and 1 kg dry urea is heated at
70°C. Then to the reaction mixture is added sodium hydrogen carbonate. 2-
Bromo-3-methylbutyrylurea is recrystallized from toluene or water, melting
point 149°C. | [Brand name]
Bromural (Knoll). | [Therapeutic Function]
Sedative, Hypnotic | [World Health Organization (WHO)]
Bromisoval is a monureide sedative of long standing. It remains
available in several countries. However, it releases the bromide ion and prolonged
usage can result in chronic bromide accumulation and intoxication. | [storage]
Store at -20°C | [Purification Methods]
Crystallise it from aqueous EtOH or toluene, and dry it in air. [Beilstein 3 H 63, 3 I 29, 3 II 51, 3 III 123, 3 IV 117.] |
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