| Identification | More | [Name]
Hydantoin | [CAS]
461-72-3 | [Synonyms]
2,4-(3H,5H)-IMIDAZOLEDIONE
2,4-IMIDAZOLIDINEDIONE
2,4-IMIDAZOLINEDIONE
GLYCOLYLUREA
HYDANTOIN
Imidazolidine-2,4-dione
2-hydroxy-2-imidazolin-4(or5)-on
2-Imidazolin-4(or 5)-one, 2-hydroxy-
Imidazole-2,4(3H,5H)-dione
Hydantoin,99%
NSC 922
glycollylurea
2,4-Imidazolidinedione ,2-hydroxy-2-imidazolin-4(or 5)-on ,glycolylurea ,hydantoin
NSC 9226
2,5-Imidazolidinedione
Imidazolidine-2,5-dione | [EINECS(EC#)]
207-313-3 | [Molecular Formula]
C3H4N2O2 | [MDL Number]
MFCD00005259 | [Molecular Weight]
100.08 | [MOL File]
461-72-3.mol |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
218-220 °C (lit.) | [Boiling point ]
187.47°C (rough estimate) | [density ]
1.4457 (rough estimate) | [vapor pressure ]
0Pa at 25℃ | [refractive index ]
1.5110 (estimate) | [storage temp. ]
Store below +30°C. | [solubility ]
SLIGHTLY SOLUBLE | [form ]
Fine Powder | [pka]
pKa 9.1 (Uncertain) | [color ]
White to light yellow | [Water Solubility ]
SLIGHTLY SOLUBLE | [Merck ]
14,4761 | [BRN ]
110598 | [LogP]
-1.69 | [CAS DataBase Reference]
461-72-3(CAS DataBase Reference) | [NIST Chemistry Reference]
2,4-Imidazolidinedione(461-72-3) | [EPA Substance Registry System]
461-72-3(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S27:Take off immediately all contaminated clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [RTECS ]
MT8210000
| [TSCA ]
Yes | [HS Code ]
29332100 |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Reactant for synthesis of: N-benzyl aplysinopsin analogs as anticancer agents1 D-glutamic acid based inhibitors2 Antidiabetic chromonyl-2,4-thiazolidinediones3 GSK-3β inhibitors with brain permeability4 Thiazolidinedione derivatives as 15-PGDH inhibitors5 Radio-sensitizing agents6 | [Definition]
ChEBI: Hydantoin is an imidazolidine-2,4-dione. | [Pharmaceutical Applications]
Control of generalized convulsive status epilepticus; prevention and treatment of seizures during neurosurgery; short-term substitute for oral phenytoin. | [Mechanism of action]
Hydantoins are a class of drugs mainly used to treat seizures (anticonvulsant or antiepileptic drugs). Hydantoins reduce seizures by targeting the sodium channel present throughout the nerves. Activation of sodium channels results in the conduction of electrical impulses and the release of neurotransmitters. It could stabilise neuronal membranes by decreasing sodium and calcium ion influx into the neurons. Also decreases post-tetanic potentiation and repetitive discharge. | [Pharmacokinetics]
Completely absorbed after IM administration. Protein binding: 95%–99%. Rapidly and completely hydrolyzed to phenytoin after IM or IV administration. Time of complete conversion to phenytoin: 4 hr after IM injection; 2 hr after IV infusion. Half-life: 8–15 min (for conversion to phenytoin).
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