496-67-3
基本信息
布洛母拉
溴米那
溴米索伐
溴米索伐(溴米那)
溴異戊脲
α-溴異戊酰脲
溴夢拉
alpha-溴異戊酰脲
N-(2-溴-3-甲基丁酰)脲
A-(BROMOISOVALERYL)UREA
ALPHA(BROMOISOVALERYL)UREA
BROMISOVAL
BROMOISOVALERYLUREA
BROMO-ISO-VALERYLUREA (ALPHA)
BROMOVALERYLUREA
LABOTEST-BB LT00134620
RARECHEM AX KI 5046
(2-bromo-3-methylbutyryl)-ure
(alpha-Bromo-.beta,beta.-dimethylpropanoyl)urea
(alpha-Bromoisovaleroyl)urea
2-Bromisovalerylmocovina
2-Bromo-3-Methylbutyrylurea
2-Bromo-3-methylbutyrylurea deaux Base GP
2-Bromo-isovaleryl urea
2-Monobromoisovalerylurea
Abroval
Alluval
alpha-Bromisovalerylurea
物理化學性質(zhì)
安全數(shù)據(jù)
496-67-3(安全特性,毒性,儲運)
報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2024/11/11 | XW49667301 | 1-(2-溴異戊酰)脲 | 496-67-3 | 25G | 186元 |
2024/11/08 | HY-B2113 | 溴米索伐 Bromisoval | 496-67-3 | 500mg | 200元 |
2024/11/08 | HY-B2113 | 溴米索伐 Bromisoval | 496-67-3 | 10mM * 1mLin DMSO | 220元 |
常見問題列表
Bromisoval (BU) suppresses nitric oxide (NO) releasing and proinflammatory cytokine expression in lipopolysaccharide (LPS)-treat BV2 cells, a murine microglial cell line. Bromisoval suppresses LPS-inducing phosphorylation of signal transducer and activator of transcription 1 (STAT1) and expression of interferon regulatory factor 1 (IRF1). The Janus kinase 1 (JAK1) inhibitor filgotinib suppresses the NO release much more weakly than that of Bromisoval, although filgotinib almost completely prevents LPS-inducing STAT1 phosphorylation. Knockdown of JAK1, STAT1, or IRF1 does not affect the suppressive effects of Bromisoval on LPS-inducing NO. A combination of Bromisoval and filgotinib synergistically suppress the NO releasing. The mitochondrial complex I inhibitor rotenone, which does not prevent STAT1 phosphorylation or IRF1 expression, suppresses proinflammatory mediator expression less significantly than Bromisoval. Bromisoval and rotenone reduce intracellular ATP (iATP) levels to a similar extent. A combination of rotenone and filgotinib suppress NO release in LPS-treated BV2 cells as strongly as Bromisoval.
Bromisoval (Bromvaletone) and carbromal are the most potent central depressants within each series. Depressant activities (ISD 50 values) and acute toxicities (LD 50 values) in male mice after intraperitoneal injection of Bromisoval are 0.35 (0.30-0.39) and 3.25 (2.89-3.62) mmol/kg, respectively.