| Identification | More | [Name]
2,6-Dichlorobenzoyl chloride | [CAS]
4659-45-4 | [Synonyms]
2,6-DICHLORBENZOYL CHLORIDE
2,6-DICHLOROBENZOYL CHLORIDE
DICHLOROBENZOYLCHLORIDE(2,6-)
Benzoyl chloride, 2,6-dichloro-
Benzoyl chloride, 2,6-dichloro-(6CI,7CI,8CI,9CI)
2,6-Dichlorobenzoyl
2,6-Dichlorbenzoylchlorid
2,6-DICHLOROBENZOYL CHLORIDE 98+%
2,6-Dichlorobenzoic acid chloride | [EINECS(EC#)]
225-102-4 | [Molecular Formula]
C7H3Cl3O | [MDL Number]
MFCD00000662 | [Molecular Weight]
209.46 | [MOL File]
4659-45-4.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear slightly yellow liquid | [Melting point ]
15-17 °C | [Boiling point ]
142-143 °C/21 mmHg (lit.) | [density ]
1.462 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.560(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
2-8°C
| [form ]
Liquid | [color ]
Clear colorless to light yellow or light pink | [Water Solubility ]
Miscible with alcohol, ether and acetone. Slightly miscible with heptane. Immiscible with water. | [Sensitive ]
Moisture Sensitive | [BRN ]
639531 | [CAS DataBase Reference]
4659-45-4(CAS DataBase Reference) | [NIST Chemistry Reference]
2,6-Dichlorobenzoyl chloride(4659-45-4) | [Storage Precautions]
Moisture sensitive |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S27:Take off immediately all contaminated clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3265 8/PG 2
| [WGK Germany ]
1
| [F ]
10-19-21 | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29163900 |
| Hazard Information | Back Directory | [Chemical Properties]
Clear slightly yellow liquid | [Uses]
2,6-Dichlorobenzoyl chloride was used:
- in substrate activity screening method for the rapid development of novel substrates and their conversion into non-peptidic inhibitors of Cys and Ser proteases
- in the synthesis of 1-acyliridoles
- in enantiocontrolled total synthesis of (-)-aspicilin
| [Uses]
2,6-Dichlorobenzoyl chloride acts as an important intermediate in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs. It is employed in the substrate activity screening method for the rapid development of novel substrates and their conversion into non-peptidic inhibitors of Cys and Ser proteases. It is also used in the preparation of 1-acyliridoles and (-)-aspicilin. In addition to this, it undergoes esterification of (fluoren-9-ylmethoxy)carbonyl (Fmoc)-amino acids to 4-alkoxybenzyl alcohol polystyrene. | [General Description]
2,6-Dichlorobenzoyl chloride participates in esterification of (fluoren-9-ylmethoxy)carbonyl (Fmoc)-amino acids to 4-alkoxybenzyl alcohol polystyrene. | [Purification Methods]
Reflux the acid chloride for 2hours with excess of acetyl chloride (3 volumes), distil off AcCl followed by the benzoyl chloride. Store it away from moisture. It is an IRRITANT.[Beilstein 9 III 1377.] |
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