| Identification | More | [Name]
Ammonium chloride | [CAS]
12125-02-9 | [Synonyms]
ACTIVITY STANDARD FOR AMMONIA ELECTRODE
AMMONIA STANDARD
AMMONII CHLORIDUM
AMMONIUM CHLORIDE
AMMONIUM CHLORIDE, 5.4 G/L
AMMONIUM CHLORIDE BUFFER
AMMONIUM CHLORIDE TS
AMMONIUM MURIATE
AMMONIUM NITROGEN
AMMONIUM-NITROGEN STANDARD
AMMONIUM STANDARD SOLUTION
AMMONIUM VOLUMETRIC STANDARD
FILLING SOLUTION FOR AMMONIA ELECTRODE
FILLING SOLUTION FOR SODIUM ELECTRODE
NH4CL
NITROGEN-AMMONIA STANDARD
NITROGEN STANDARD
SAL AMMONIAC
SALMIAC
SALT AMMONIAC | [EINECS(EC#)]
235-186-4 | [Molecular Formula]
ClH4N | [MDL Number]
MFCD00011420 | [Molecular Weight]
53.49 | [MOL File]
12125-02-9.mol |
| Chemical Properties | Back Directory | [Appearance]
Ammonium chloride is a white crystalline
solid. Odorless. | [Melting point ]
340 °C (subl.) (lit.) | [Boiling point ]
100 °C750 mm Hg
| [density ]
1.52 | [vapor density ]
1.9 (vs air)
| [vapor pressure ]
1 mm Hg ( 160.4 °C)
| [FEMA ]
4494 | AMMONIA (ALSO INCLUDES AMMONIUM CHLORIDE) | [refractive index ]
1.642 | [storage temp. ]
Store at RT. | [solubility ]
H2O: 1 M at 20 °C, clear, colorless
| [form ]
Solid | [pka]
9.25[at 20 ℃] | [color ]
White | [Specific Gravity]
1.53 | [Odor]
odorless | [PH]
4.7 (200g/l, H2O, 25℃)(External MSDS) | [Stability:]
Stable. Incompatible with strong acids, strong bases. | [Odor Type]
ammoniacal | [Water Solubility ]
soluble | [Sensitive ]
Hygroscopic | [λmax]
λ: 260 nm Amax: ≤0.021
λ: 280 nm Amax: ≤0.019 | [Merck ]
14,509 | [BRN ]
4371014 | [Dielectric constant]
7（0.0℃） | [Exposure limits]
ACGIH: TWA 10 mg/m3; STEL 20 mg/m3
NIOSH: TWA 10 mg/m3; STEL 20 mg/m3 | [Uses]
Ammonium Chloride is a dough conditioner and yeast food that
exists as colorless crystals or white crystalline powder. approximately
30–38 g dissolves in water at 25°c. the ph of a 1% solution at 25°c
is 5.2. it is used as a dough strengthener and flavor enhancer in
baked goods and as a nitrogen source for yeast fermentation. it is
also used in condiments and relishes. another term for the salt is
ammonium muriate. | [CAS DataBase Reference]
12125-02-9(CAS DataBase Reference) | [NIST Chemistry Reference]
Ammonium chloride(12125-02-9) | [EPA Substance Registry System]
12125-02-9(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R36:Irritating to the eyes.
R41:Risk of serious damage to eyes.
R37/38:Irritating to respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
UN 3077 9 / PGIII | [WGK Germany ]
1
| [RTECS ]
BP4550000
| [Autoignition Temperature]
>400 °C | [TSCA ]
Yes | [HazardClass ]
9 | [PackingGroup ]
III | [HS Code ]
28271000 | [Safety Profile]
Poison by subcutaneous, intravenous, and intramuscular routes. Moderately toxic by other routes. A severe eye irritant. Mutation data reported. Explosive reaction with potassium chlorate or bromine trifluoride. Violent reaction (ignition) with bromine pentafluoride, NH4, Nos, and IF7. Reaction with hydrogen cyanide may give the explosive nitrogen trichloride. When heated to decomposition it emits very toxic fumes of NO,, Cl-, and NH3. | [Hazardous Substances Data]
12125-02-9(Hazardous Substances Data) | [Toxicity]
LD50 in rats (mg/kg): 30 i.m. (Boyd, Seymour); LD50 in rats (mg/kg): 1650 orally (Smeets) |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Hydrochloric acid-->Sodium sulfate-->Sodium chloride-->Ammonia-->Carbon dioxide-->Ammonium bicarbonate-->4-Chlorobenzaldehyde-->Hydroquinone-->Potassium chloride-->Ammonium sulfate-->Ammonium nitrate-->HEAVY CUT RESIDUE OIL-->Propylene carbonate | [Preparation Products]
Iridium-->Ethyl benzoylformate-->3-PYRIDINECARBOXAMIDINE-->2-Furaldehyde diethyl acetal-->Tricyclohexyl phosphine-->4-PYRIDINECARBOXAMIDINE-->TRIHEXYLPHOSPHINE-->Ammonium dichromate-->CYCLOLEUCINOL-->Methyl 3-aminosulfonylthiophene-2-carboxylate-->1-Naphthyl isocyanate-->3-METHYLTHIOPHENE-2-CARBOXAMIDE-->Kanamycin sulfate-->Dye-fixing agent M-->4-AMIDINOPYRIDINIUM CHLORIDE-->2-NAPHTHYL ISOCYANATE-->2-Chloro-5-chloromethylthiophene-->2-Formylfuran-5-boronic acid-->4-NITROBENZAMIDINE, HYDROCHLORIDE-->4-(4-CHLOROPHENYL)-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE-->2-AMINO-4,6-DIMETHYL-3-PYRIDINECARBOXAMIDE-->Pyridine-2-carboximidamide hydrochloride-->2,5-Dichlorothiophene-3-sulfonamide-->Praseodymium-Zircon Yellow-->Elastase-->interferon-gamma-1a-->5-(AMINOMETHYL)-5-METHYLPYRROLIDIN-2-ONE-->4-METHOXYBENZAMIDINE, HYDROCHLORIDE-->4-METHOXY-BENZAMIDINE-->4-Chlorobenzene-1-carboximidamide hydrochloride-->4-METHYL-BENZAMIDINE-->4-Methylbenzene-1-carboximidamide hydrochloride-->Amino tris(methylene phosphonic acid)-->THIOTHIAMINE-->color fixing agent Y-->1,3-DICHLORO-2-BUTENE-->1-PHENYL-3-THIOSEMICARBAZIDE-->xylene isomerization catalysts-->new type low toxic urea-formalde-hyde adhesive A-01-B-->3,4-Dichloro-1,2,5-thiadiazole |
| Hazard Information | Back Directory | [General Description]
AMMONIUM CHLORIDE(12125-02-9) is a white crystalline solid. AMMONIUM CHLORIDE(12125-02-9) is soluble in water(37%). The primary hazard is the threat posed to the environment. Immediate steps should be taken to limit its spread to the environment. AMMONIUM CHLORIDE(12125-02-9) is used to make other ammonium compounds, as a soldering flux, as a fertilizer, and for many other uses. | [Reactivity Profile]
Acidic salts, such as AMMONIUM CHLORIDE, are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions. | [Air & Water Reactions]
Soluble in water. Slowly releases hydrogen chloride [USCG, 1999]. | [Hazard]
Eye and upper respiratory tract irritant.
| [Health Hazard]
Inhalation of fumes irritates respiratory passages. Ingestion irritates mouth and stomach. Fumes are irritating to eyes. Contact with skin may cause irritation. | [Potential Exposure]
Ammonium chloride is used as an
industrial chemical, pharmaceutical, and veterinary drug; to
make dry batteries; in galvanizing; as a soldering flux. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions, including
resuscitation mask) if breathing has stopped and CPR if
heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get medical
attention. Give large quantities of water and induce
vomiting. Do not make an unconscious person vomit. | [Shipping]
UN3077 Environmentally hazardous substances,
solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous
hazardous material, Technical Name Required. | [Incompatibilities]
Acids, alkalis, and silver salts. | [Waste Disposal]
Pretreatment involves addition
of sodium hydroxide to liberate ammonia and form the
soluble sodium salt. The liberated ammonia can be recovered
and sold. After dilution to the permitted provisional
limit, the sodium salt can be discharged into a stream or
sewer. | [Physical properties]
Colorless cubic crystals or white granular powder; saline taste; odorless; hygroscopic; does not melt but sublimes on heating at 340°C; vapor pressure 48.75 torr at 250°C and 251.2 torr at 300°C; density 1.5274 g/cm3 at 25°C; refractive index 1.642; readily dissolves in water, solubility: 229 g and 271 g/L solution at O°C and 20°C, respectively; solubility lowered by alkali metal chlorides and HCl; dissolution lowers the temperature of the solution; sparingly soluble in alcohols (6 g/L at 19°C) and soluble in liquid NH3; insoluble in acetone and ether. | [Occurrence]
Ammonium chloride occurs in nature in crevices near volcanoes. Also, it is found in smoke when burning dry camel or donkey dung as fuel. Important applications of this compound include the manufacture of dry cells for batteries; as a metal cleaner in soldering; as a flux in tin coating and galvanizing; in fertilizers; in pharmaceutical applications as a diuretic, or diaphoretic expectorant; and as an analytical standard in ammonia analysis. Also, it is used in freezing mixtures; washing powders; lustering cotton; in safety explosives and in dyeing and tanning. | [Application]
Ammonium chloride(12125-02-9) is also known as sal ammoniac. white crystals made by ammonia salts acting upon hydrochloric acid followed by crystallization. It was used as a halide in many processes, including the salted paper, albumen paper, albumen opaltype, and gelatin emulsion processes. ammonium chloride is also used as a thickener and as an additive in non-alcoholic toners. According to cosmetic formulators, the ammonium component provides the tingling or stinging sensation that some people associate with toners or aftershaves, and which, in regular toners, is usually provided by the alcohol content. Ammonium chloride’s use is the result of preference in formulation feel.
| [Definition]
ChEBI: An inorganic chloride having ammonium as the counterion. | [Definition]
sal ammoniac: A white or colourless cubicsolid, NH4Cl; r.d. 1.53; sublimes at340°C. It is very soluble in water andslightly soluble in ethanol but insolublein ether. It may be prepared byfractional crystallization from a solutioncontaining ammonium sulphateand sodium chloride or ammoniumcarbonate and calcium chloride. Puresamples may be made directly by thegas-phase reaction of ammonia andhydrogen chloride. Because of itsease of preparation it can be manufacturedindustrially alongside anyplant that uses or produces ammonia.The compound is used in drycells, metal finishing, and in thepreparation of cotton for dyeing andprinting. | [Preparation]
Ammonium chloride is prepared commercially by reacting ammonia with hydrochloric acid. It may be prepared by fractional crystallization from a solution containing ammonium sulphate and sodium chloride or ammonium carbonate and calcium chloride. Because of it sease of preparation it can be manufacture dindustrially along side any plant that uses or produces ammonia. Ammonium chloride is used in dry cells, metal finishing, and in the preparation of cotton for dyeing and printing. | [Production Methods]
Ammonium chloride is prepared commercially by reacting ammonia
with hydrochloric acid. | [Flammability and Explosibility]
Nonflammable | [Agricultural Uses]
Ammonium chloride(12125-02-9), like all other ammonium salts, is
used as a fertilizer. It contains 24 to 26% nitrogen and is
available as white crystals or granules. A coarse form of
this fertilizer is preferred to the powdered form for direct
application. Its crystals are used in compound fertilizers.
Ammonium chloride is a good source of nitrogen for
cotton, rice, wheat, barley, maize, sorghum, sugar cane
and fiber crops. It is easy to handle. In some cases,
however, the material tends to become lumpy and
difficult to spread.
Ammonium chloride is used either directly for
fertilization or in a variety of compound fertilizers, such
as ammonium phosphate chloride or ammonium
potassium chloride or in combination with urea or
ammonium sulphate.
As a fertilizer, ammonium chloride has an advantage
in that it contains 26% nitrogen, which is higher than that
found in ammonium sulphate (20.5%). In terms of per
unit cost of nitrogen, ammonium chloride is relatively
cheaper than ammonium sulphate and has some
agronomic advantages for rice. Nitrification of
ammonium chloride is less rapid than that of urea or
ammonium sulphate. Therefore, nitrogen losses are
lower and yields, higher.
However, ammonium chloride is a highly acid
forming fertilizer and the amount of calcium carbonate
required to neutralize the acidity is more than the
fertilizer itself, Further, it has a lower nitrogen content
and a higher chloride content compared to urea and
ammonium nitrate, making it harmful to some plants.
Several methods are used to produce ammonium
chloride. The most important is the dual-salt process
(modified Solvay process) wherein ammonium chloride
and sodium carbonate are produced simultaneously using
common salt and anhydrous ammonia as the principal
starting materials. When ammonium chloride is mixed
with phosphatic and potassic fertilizers, a large amount of
soil calcium is lost as its conversion into soluble calcium
chloride causes it to leach out easily.
Like ammonium sulphate, ammonium chloride can be
applied to wet land crops. In terms of the agronomic
suitability, it is generally rated as equal to other straight
nitrogenous fertilizers.
Ammonium chloride is, however, not ideal for
grapes, chilies, potatoes and tobacco as the added
chlorine affects the quality and storability of these crops.
Industrial uses of ammonium chloride are in
dry-battery manufacture and as a flux for soldering and
brazing.
| [Biochem/physiol Actions]
Ammonium chloride is one of the three principal components of the nitrogen cycle. Ammonium chloride administration promotes creatinine and urea clearance andinduces metabolic acidosis in mice. Excess of ammonium chloride inhibits Kreb′s pathway in brain and depletes ATP in astrocytes. Ammonium chloride inhibits acidification in the endosome-lysosome system. Ammonium chloride is a hemolysing agent used for the lysis of erythrocytes. | [Safety]
Ammonium chloride is used in oral pharmaceutical formulations.
The pure form of ammonium chloride is toxic by SC, IV, and IM
routes, and moderately toxic by other routes. Potential symptoms of
overexposure to fumes are irritation of eyes, skin, respiratory
system: cough, dyspnea, and pulmonary sensitization. Ammonium
salts are an irritant to the gastric mucosa and may induce
nausea and vomiting.
LD50 (mouse, IP): 1.44 g/kg
LD50 (mouse, oral): 1.3 g/kg
LD50 (rat, IM): 0.03 g/kg
LD50 (rat, oral): 1.65 g/kg | [Veterinary Drugs and Treatments]
The veterinary indications for ammonium chloride are as a urinary
acidifying agent to help prevent and dissolve certain types of uroliths
(e.g., struvite), to enhance renal excretion of some types of toxins
(e.g., strontium, strychnine) or drugs (e.g., quinidine), or to enhance
the efficacy of certain
antimicrobials (e.g., chlortetracycline, methenamine
mandelate, nitrofurantoin, oxytetracycline, penicillin G or
tetracycline) when treating urinary tract infections. Ammonium
chloride has also been used intravenously for the rapid correction
of metabolic alkalosis.
Because of changes in feline diets to restrict struvite and as struvite
therapeutic diets (e.g., s/d) cause aciduria, ammonium chloride
is not commonly recommended for struvite uroliths in cats. | [storage]
Ammonium chloride is chemically stable. It decomposes completely
at 3388℃ to form ammonia and hydrochloric acid. Store in airtight
containers in a cool, dry place. | [Purification Methods]
Crystallise it several times from conductivity water (1.5mL/g) between 90o and 0o. It sublimes. After one crystallisation, ACS grade has: metal(ppm) As (1.2), K (1), Sb (7.2), V (10.2). [Becher in Handbook of Preparative Inorganic Chemistry (Ed. Brauer) Academic Press Vol I p 812 1963.] | [Regulatory Status]
GRAS listed. Included in the FDA Inactive Ingredients Database
(oral syrup, tablets). Accepted for use as a food additive in Europe.
Included in medicines licensed in the UK (eye drops; oral syrup). |
| Questions And Answer | Back Directory | [description]
Ammonium chloride (referred to as "chloramine", also known as halogen sand, chemical formula: NH4Cl) is colorless cubic crystal or white crystalline powder. It tastes salty and slightly bitter and belongs to acid salt. Its relative density is 1.527. It is soluble in water, ethanol and liquid ammonia but insoluble in acetone and ether. The aqueous solution is weakly acidic, and its acidity is enhanced while heating. When heated to 100 ° C, it begins to significantly volatilize, and when heated to 337.8 ° C, it will dissociate into ammonia and hydrogen chloride, which, on cold exposure, will re-combine to produce small particles of ammonium chloride and white smoke that is not easy to sink and very difficult to be dissolved in water. When heated to 350 ° C ,it will sublimate and when 520 ° C, it will boil. Its moisture absorption is small, and in the wet rainy weather can absorb moisture to cake. For the ferrous metals and other metals, it is corrosive, which, in particular, has greater corrosion of copper but no corrosion of pig iron. Ammonium chloride can be obtained from the neutralization reaction of ammonia and hydrogen chloride or ammonia and hydrochloric acid (reaction equation: NH3 + HCl → NH4Cl). When heated, it will decompose into hydrogen chloride and ammonia reaction (equation: NH4Cl → NH3 + HCl) and the reaction is only to the right if the container is open system.
ammonium chloride powder | [Chemical properties]
Ammonium chloride NH4Cl (also called sal ammoniac) is a colourless crystal or white granular powder that dissolves easily in water.It is odourless and has a salty and bitter taste. It sublimes on heating to form ammonia and hydrogen chloride (gas). It is commonly used in the baked goods industry, as a functional salt and as a dough improver for yeasts.It gives the dough good elasticity,extensibility, and machinability, producing breads with good quality characteristics in terms of volume,colour, aroma, texture,and elasticity.Ammonium chloride is considered safe in small amounts. The Us Food and Drug Administration (FDA) granted ammonium hydroxide status as a GRAS, or Generally Recognized as Safe, substance in 1974 and it is also recognised as a food additive in the EU. | [Uses]
Ammonium chloride is mainly used for dry batteries, storage batteries, ammonium salts, tanning, plating, medicine, photography, electrodes, adhesives, etc. Ammonium chloride is also an available nitrogen chemical fertilizer whose nitrogen content is 24% to 25%. It is a physiological acidic fertilizer and suitable for wheat, rice, corn, rapeseed and other crops. It have the effects of enhancing fiber toughness and tension and improving quality especially for cotton and linen crops. However, due to the nature of ammonium chloride, if the application is not right, it will bring some adverse effects to soil and crops.
Technical conditions: the implementation of the People's Republic of China national standard GB-2946-82.
1. Appearance: white crystal
2. ammonium chloride content (dry basis) ≥ 99.3%
3. moisture content ≤1.0%
4. sodium chloride content (dry basis) ≤0.2%
5. iron content ≤0.001%
6. heavy metal content (in terms of Pb) ≤0.0005%
7. water insoluble content ≤0.02%
8. sulfate content (in terms of SO42-) ≤0.02%
9. pH: 4.2-5.8 | [Production method]
(1) Recrystallization method: the industrial ammonium chloride is added into the dissolver which has been filled with distilled water, and dissolved by heating. The obtained solvents is purified by arsenic removal and heavy metal removal, and then filtered, cooled for crystallization, centrifuged and dried. Finally the chemical ammonium chloride is finished.
(2) Metathesis method: the mother liquor of ammonium chloride is added to reactor and heated to 105 ° C. Add ammonium sulfate and salt under stirring and proceed metathesis reaction at 117 ° C, resulting in forming ammonium chloride solution and sodium sulfate crystallization. The obtained mixture is then filtrated and separated to remove sulfuric acid Sodium. Add arsenic removal and heavy metal removal to the filtrate and filtrate to remove arsenic, heavy metals and other impurities. The filtrate is sent to a cooling crystallizer and is cooled to 32-35 ℃ to precipitate the crystals. The crystals are filtered and washed with ammonium chloride solution, and then are dehydrated by centrifugal separation and dried to obtain finished edible ammonium chloride. Reaction formula：
(NH4) 2SO4 + 2NaCl→2NH4Cl + Na2SO4
Recrystallization method: the industrial ammonium chloride is added into the dissolver which has been filled with distilled water, and dissolved by heating. The obtained solvents is purified by arsenic removal and heavy metal removal, and then filtered, cooled for crystallization, centrifuged and dried. Finally the edible ammonium chloride is finished.
(3) The mother liquor was filtrated by associated alkali method and cooled for crystallization, and then add salt powder to salt out the product.
It can also be obtained by derived replacement reaction of ammonium sulfate and calcium chloride in aqueous solution.
(4) Gas-liquid phase synthesis: hydrogen chloride gas is added from the bottom of the turbulence absorption tower and then contact with the circulating mother liquor flowing from overhead spray to generate chloride mother liquor containing saturated ammonium chloride. Chloride mother liquor then flows into the reactor and react with ammonia gas to form a saturated ammonium chloride solution. The obtained solvents are sent to the cooling crystallizer and cooled to 30~45 ° C to precipitate supersaturated ammonium chloride crystals. The ammonium chloride solution in the upper part of the crystallizer is sent to the air cooler for cooling and circulating to the crystallizer; the crystal slurry in the lower part of the crystallizer is thickened by thickening thickener and centrifuged for separation to obtain ammonium chloride. Reaction formula:
HCl + NH3 → NH4Cl
The mother liquor separated by centrifugation is sent to the turbulent absorption tower for recycling.
Metathesis method: the mother liquor of ammonium chloride is added to reactor and heated to 105 ° C. Add ammonium sulfate and salt under stirring and proceed metathesis reaction at 117 ° C, resulting in forming ammonium chloride solution and sodium sulfate crystals. The obtained mixture is then filtrated to remove sulfuric acid Sodium and the filtrate is sent to cooling crystallizer and cooled to 32 to 35 ℃ for crystallization. Then the crystals of ammonium chloride is obtained by filtration and respectively washed by 4 different concentrations (15～17°Bé，11～12°Bé，10°Bé，9.5～10°Bé) of ammonium chloride solution, controlling Fe < 0.008%, SO42-< 0.001%. After elution to qualified, use ammonium chloride solution to remake the crystals into slurry, put into the centrifuge for separation and dehydration. And then dry by hot air and obtain the industrial ammonium chloride products. Reaction formula:
2NaCl + (NH4) 2SO4 → 2NH4Cl + Na2SO4
The mother liquor is sent to the metathesis reactor for recycling. The separated sodium sulfate is filtered to produce sodium sulfate. The crude ammonium chloride is added into the dissolving device, dissolved in the steam and filtered. The filtrate is cooled for crystallization, centrifugalized and dried to obtain the finished products of industrial ammonium chloride. The mother liquor from the centrifugal separation is returned to the dissolver for use. |
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