| Identification | Back Directory | [Name]
Prostaglandin F2a tris salt | [CAS]
38562-01-5 | [Synonyms]
583e
u14585
lutalyse
PGF2αTris
PGF2ALPHA
u-14,583e
Ensaprost
Zinoprost
haminesalt
PGF2α THAM
NSC 196515
PGF2α THAM
PGF2a-THAM
THAM PGF2α
Pronalgon F
thampgf2-alpha
PGF2ALPHA THAM
PGF2ALPHA-TRIS
Minprostin F2α
PGF2α THAM salt
PGF2α Tris salt
Tromethamine salt
PGF2α tromethamine
PGF2ALPHA TRIS SALT
DINOPROST TROMMETAMOL
Dinoprost Trometamine
Prostaglandin F2α THAM
Prostaglandin F2α-tham
prostaglandin F2A tris
pgf2-alphatromethamine
DINOPROST TROMETHAMINE
PGF2α tromethamine salt
Dinorprost tromethamine
9α,11α-PGF2 TroMethaMine
Dinoprostol tromethamine
Dinoprost trometamol CRS
9α,11α-PGF2α TroMethaMine
PGF2α (Prostaglandin F2α)
prostaglandinf2-alphatham
pgf2-alphatromethaminesalt
dinoprost, trometamol salt
Dinoprost TroMethaMine USP
Prostaglandin F2α THAM salt
Prostaglandin F2α tris salt
prostaglandin f2a tris salt
prostaglandinf2atromethamine
protaglandinf2-alpha-thamsalt
DINOPROST (TROMETHAMINE SALT)
prostaglandinf2-alphathamsalt
Prostaglandin F2α tromethamine
Tromethamine prostaglandin F2α
Dinoprost Tromethamine (50 mg)
PROSTAGLANDIN F2ALPHA TRIS SALT
PROSTAGLANDINS F2ALPHA TRIS SALT
Dinoprost Tromethamine (1213001)
compd.withtrimethylolaminomethane
tromethamineprostaglandinf2-alpha
PROSTAGLANDIN F2ALPHA TROMETHAMINE
Dinoprostaglandin aminobutanol salt
Prostaglandin F2α tromethamine salt
Prostaglandin F2a tromethamine salt
Prostaglandin F2α (tromethamine salt)
Prostaglandin F2a tris salt,38562-01-5
prostaglandin F2-alpha, trometamol salt
PROSTAGLANDIN F2ALPHA TROMETHAMINE SALT
PROSTAGLANDIN F2-ALPHA, TRIMETHAMINE SALT
PROSTAGLANDIN F2A TRIS CELL*CULTURE TEST ED
Dinoprost Prostaglandin F2α Tromethamine Salt
Dinoprost Prostaglandin F2α Tromethamine Salt
Prostaglandin F2α tris(hydroxymethyl)aminomethane
PROSTAGLANDIN F2A TRIS GAMMA-IRRADIATED CELL CULTUR
Prostaglandin F2α tris(hydroxymethyl)aminomethane salt
7-[3,5-dihydroxy-2-(3-hydroxyoct-1-enyl)cyclopentyl]-5-heptenoic acid
PROSTAGLANDIN F2A TROMETHAMINE SALT;PGF2Α THAM;PROSTAGLANDIN F2Α THAM
Dinoprost compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
9α,11α,15(S)-Trihydroxy-5-cis-13-trans-prostadienoic Acid TroMethaMine
7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-5-heptenoicacitham
(5z,9a,11a,13e,15s)-9,11,15-trihydroxyprosta-5,13-dienoic acid tris salt
(5z,9α,11α,13e,15s)-9,11,15-trihydroxyprosta-5,13-dienoic acid tris salt
(5z,9-alpha,11-alpha,13e,15s)-9,11,15-trihydroxy-prosta-13-dien-1-oicacid
7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-5-heptenoicacid,tromet
[5Z,9ALPHA,11ALPHA,13E,15S]-9,11,15-TRIHYDROXYPROSTA-5,13-DIENOIC ACID TRIS SALT
7-[3,5-Dihydroxy-2-(3-hydroxy-1-
octenyl)cyclopentyl]-5-heptenoic Acid TroMethaMine
9α,11α,15S-Trihydroxy-prosta-5Z,13E-dien-1-oic acid tris(hydroxymethyl)aminomethane salt
PGF2α-Tris, (5Z,9α,11α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dienoic acid tris salt
9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, TRIS(HYDROXYMETHYL) AMINOMETHANE SALT
(5Z,9α,11α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dien-1-oic Acid 2-AMino-2-(hydroxyMethyl)-1,3-propanediol
1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, (5Z,9α,11α,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oate (salt) (9CI)
PGF2α-Tris, Prostaglandin F2α tris salt, (5Z,9α,11α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dienoic acid tris salt
Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9α,11α,13E,15S)-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
2-amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)cyclopentyl)hept-5-enoate
Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9.alpha.,11.alpha.,13E,15S)-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
(E,Z)-(1R,2R,3R,5S)-7-[3,5-Dihydroxy-2-[(3S)-(3-hydroxy-1-octenyl)]cyclopentyl]-5-heptenoic acid compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)@component of prostin F2 alpha, injectable | [EINECS(EC#)]
254-002-3 | [Molecular Formula]
C24H45NO8 | [MDL Number]
MFCD00077863 | [MOL File]
38562-01-5.mol | [Molecular Weight]
475.62 |
| Chemical Properties | Back Directory | [Melting point ]
100-101° | [storage temp. ]
−20°C
| [solubility ]
H2O: 1 mg/mL Aqueous solutions are stable for 30 days at 2-8°C and for several months frozen at −0°C in single use aliquots. Avoid repeated freeze/thaw cycles.
| [form ]
powder
| [color ]
white
| [Merck ]
13,7970 | [BRN ]
4087514 | [Stability:]
Hygroscopic | [InChIKey]
IYGXEHDCSOYNKY-RZHHZEQLSA-N |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
One of the most biologically studied of the primary prostaglandins. Closely related to Prostaglandin E2 (PGE2) in that both
prostaglandins are biosynthesized from the same precursors and that PGF2 is
the synthetic reduction product of PGE2. Phospholipase A2 (PLA2) is a key enzyme for biosynthesis of PGF2α.
Oxytocic; abortifacient. | [Brand name]
Prostin F2 Alpha (Pharmacia
& Upjohn). | [Description]
Dinoprost tromethamine is a synthetic analogue of prostaglandin. F2α is an autocrine hormone present in many mammalian tissues. It is used to cause luteolysis in the cow, sow and mare. It is given as a single injection by im or sc routes, the recommended dosage rate is 25 mg cow; 10 mg sow and 5 mg mare. It is rapidly absorbed from the injection site. It has an extremely short half life of only a few minutes, it is almost completely cleared following one or two passages through the liver and/or lungs. | [Originator]
Prostin F2A,Upjohn,UK,1972 | [Definition]
dinoprost tromethamine is a synthetic analogue of the naturally occurring prostaglandin F2 alpha. Prostaglandin F2 alpha stimulates myometrial activity, relaxes the cervix, inhibits corpus luteal steroidogenesis, and induces luteolysis by direct action on the corpus luteum. | [Indications]
Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost tromethamine salt is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost tromethamine salt plays a key role in the onset and progression of labour. | [Manufacturing Process]
A solution of tris(hydroxymethyl)aminomethane (1.645 grams) in 3.0 ml of
water at 60°C is added with vigorous stirring to a solution of PGF2α, (5.00
grams) in 700 ml of acetonitrile which has just been
ought to its boiling
point. The vessel which contained the aqueous amine solution is rinsed with
three 0.66 ml portions of water, each rinsing being added with vigorous
stirring to the acetonitrile solution. The mixture is then cooled to 25°C by
immersion of the vessel in cool water. At the cloud point, the vessel wall
(glass) below the liquid surface is scratched vigorously with a glass rod. The
mixture is then maintained at 25°C for 24 hours.
The resulting crystals are collected by filtration under nitrogen, washed on the
filter with 50 ml of acetonitrile, and then dried by passing nitrogen at 50°C
through the filter cake for one hour. Drying is completed in an oven at 70°C
for 8 hours to give 5.965 grams of the tris(hydroxymethyl)aminomethane salt of PGF2α in free flowing crystalline form; MP 100°-101°C. | [Therapeutic Function]
Smooth muscle stimulant | [Biochem/physiol Actions]
Prostaglandin F2α is induced by uterine-produced oxytocin and acts on the corpus luteum to cause luteolysis and inhibit progesterone production. | [storage]
Store at -20°C |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
60-22 | [Safety Statements ]
53-45 | [WGK Germany ]
3
| [RTECS ]
UK8025000
| [F ]
8-10 | [HS Code ]
2937500000 | [Safety Profile]
Poison by intraperitoneal, subcutaneous, intravenous, and intramuscular routes. Moderately toxic by ingestion. Human reproductive effects by intervagmal route: terminates pregnancy, effects on fertility. Experimental teratogenic and reproductive effects. When heated to
decomposition it emits toxic fumes of NOx. See also other prostaglandin entries. |
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