38562-01-5
中文名稱
地諾前列素氨丁三醇
英文名稱
Dinoprost tromethamine
CAS
38562-01-5
分子式
C24H45NO8
分子量
475.62
MOL 文件
38562-01-5.mol
更新日期
2024/12/20 13:38:27
38562-01-5 結(jié)構(gòu)式
基本信息
中文別名
緩血酸胺鹽二諾前列特羅莫
地諾前列素氮三丁醇
氨丁三醇地諾前列素
地諾前列素氨丁三醇
地諾前列腺素 氨丁三醇
前列腺素 F2ΑTRIS 鹽
地諾前列素氨丁三醇 EP標(biāo)準(zhǔn)品
地諾前列素氨丁三醇 USP標(biāo)準(zhǔn)品
地諾前列素氨丁三醇/前列腺素F2ΑTRIS鹽
英文別名
583eu14585
lutalyse
PGF2αTris
Ensaprost
u-14,583e
PGF2ALPHA
Zinoprost
PGF2a-THAM
THAM PGF2α
所屬類別
分析化學(xué)：藥典標(biāo)準(zhǔn)品和雜質(zhì)標(biāo)準(zhǔn)品物理化學(xué)性質(zhì)
熔點100-101°
儲存條件−20°C
儲存條件-20°C
溶解度H2O: 1 mg/mL Aqueous solutions are stable for 30 days at 2-8°C and for several months frozen at −0°C in single use aliquots. Avoid repeated freeze/thaw cycles.
溶解度在水中的溶解度1 mg/mL水溶液在2-8°C下可穩(wěn)定保存30天，在−0°C下單獨保存數(shù)月使用等分試樣。避免反復(fù)冷凍/解凍循環(huán)。
形態(tài)powder
顏色white
Merck13,7970
BRN4087514
穩(wěn)定性吸濕性
InChIKeyIYGXEHDCSOYNKY-RZHHZEQLSA-N
安全數(shù)據(jù)
警示詞危險
危險性描述H302-H360FD
危險品標(biāo)志T
危險類別碼60-22
安全說明53-45
WGK Germany3
WGK Germany3
RTECS號UK8025000
F8-10
海關(guān)編碼2937500000
常見問題列表
生物活性
Dinoprost Tromethamine (Dinolytic, PGF2-alpha tham, Zinoprost, Prostin F2 alpha, Dinoprost Trometamol) 是一種合成的prostaglandin F2 alpha類似物，prostaglandin F2 alpha可通過直接作用于黃體素，刺激子宮肌層活性、使宮頸舒張、抑制黃體類固醇生成、誘導(dǎo)黃體溶解。靶點
|
FP Receptor
|
Human Endogenous Metabolite
|
體外研究
Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt; 1 μM; for 24 hours) induces ER stress, autophagy, and apoptosis in goat luteal cells.
Dinoprost tromethamine salt (1 μM; for 24 hours) significantly increases the expression of GRP78 and UPR sensors.
Apoptosis Analysis
| Cell Line: | Goat luteal cells |
| Concentration: | 1 μM |
| Incubation Time: | For 24 hours |
| Result: | Significantly increased the apoptotic rate (15.62±3.12%). |
Cell Autophagy Assay
| Cell Line: | Goat luteal cells |
| Concentration: | 1 μM |
| Incubation Time: | For 24 hours |
| Result: | There was extensive overlap between LC3 and LAMP1 in luteal cells and autophagolysosomes were formed in goat luteal cells. |
Western Blot Analysis
| Cell Line: | Goat luteal cells |
| Concentration: | 1 μM |
| Incubation Time: | For 24 hours |
| Result: | The expression of GRP78 and UPR sensors including cleaved ATF6, phosphorylated-EIF2S1, EIF2S1, ATF4, phosphorylated-IRE1, autophagy-related protein LC3-II, and pro-apoptosis factor cleaved Caspase3 increased significantly in the cells. |