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ChemicalBook--->CAS DataBase List--->145202-66-0

145202-66-0

145202-66-0 Structure

145202-66-0 Structure
IdentificationMore
[Name]

Rizatriptan benzoate
[CAS]

145202-66-0
[Synonyms]

MAXALT
MK-0462
MK-462
n,n-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1h-indol-3-yl]ethylamine benzoate
N,N-DIMETHYL-5-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1H-INDOLE-3-ETHANAMINE, BENZOATE
RIZATRIPTAN BENZOATE
RIZATRIPTANE BENZOATE
Rizatrimptan Benzoate
Rizatrimptan
Rizatriptan monobenzoate
N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-
Rizatriptan benzoate,MaxaLt
[EINECS(EC#)]

604-465-6
[Molecular Formula]

C22H25N5O2
[MDL Number]

MFCD00866224
[Molecular Weight]

391.47
[MOL File]

145202-66-0.mol
Chemical PropertiesBack Directory
[Melting point ]

178-180°C
[storage temp. ]

2-8°C
[solubility ]

H2O: ≥5mg/mL
[form ]

powder
[color ]

white to beige
[Usage]

A selective serotonin 5-HTID receptor agonist. Structurally derived from tryptamine
[Merck ]

14,8241
[InChIKey]

JPRXYLQNJJVCMZ-UHFFFAOYSA-N
[CAS DataBase Reference]

145202-66-0(CAS DataBase Reference)
Safety DataBack Directory
[Hazard Codes ]

T
[Risk Statements ]

61
[WGK Germany ]

3
[HS Code ]

2933995500
Questions And AnswerBack Directory
[Description]

Known as a 5-hydroxytryptamine agonist, Rizatriptan Benzoate is the benzoate salt form of rizatriptan with anti-migraine activity, which can be used to treat the migraine headaches. It is FDA-approved to use in the treatment of acute migraine attacks with or without aura, especially taken at the first sign of a migraine headache. However, it cannot prevent future migraine attacks and it is ineffective to prevent other types of headache.
The pain of migraine headaches is believed to be induced by dilated blood vessels inside the head. Rizatriptan Benzoate relieves the pain by inducing vasoconstriction, which functions as an agonist at serotonin 5-HT1B and 5-HT1D receptors. The selective receptor binding is effective to constrict cranial vessels and inhibit the transmission of nociception, thus providing relief of migraine headaches.
[References]

https://en.wikipedia.org/wiki/Rizatriptan
https://pubchem.ncbi.nlm.nih.gov/compound/77997#section=Top
http://bodyandhealth.canada.com/drug/getdrug/co-rizatriptan-odt
Hazard InformationBack Directory
[Chemical Properties]

Off-White Solid
[Originator]

Merck & Co (US)
[Uses]

A selective serotonin 5-HTID receptor agonist. Structurally derived from tryptamine
[Uses]

Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonist triptan drug for the treatment of migraine headaches. It is believed to work by narrowing the blood vessels around the brain. Rizatriptan also reduces the substances in the body, which can also reduce headac
[Definition]

ChEBI: Rizatriptan benzoate is a member of tryptamines.
[Brand name]

Maxalt (Merck).
[General Description]

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
[Biochem/physiol Actions]

Rizatriptan is a serotonin 5HT-1B/1D-receptor agonist used to treat migraine.
Spectrum DetailBack Directory
[Spectrum Detail]

Rizatriptan benzoate(145202-66-0)1HNMR
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