| Identification | More | [Name]
1H-Benzotriazole | [CAS]
95-14-7 | [Synonyms]
1,2,3-1H-BENZOTRIAZOLE
1,2,3-BENZOTRIAZOLE
1H-1,2,3-BENZOTRIAZOLE
1H-BENZOTRIAZOLE
AKOS 92210
AMINOAZOPHENYLENE
AZIMIDOBENZENE
BENZOTRIAZOLE
COBRATEC(R) 99
1,2,3-benzotriazole-1h-benzotriazole
1,2,3-Benztriazole
1,2,3-Triaza-1H-indene
1,2,3-Triazaindene
1,2,-aminozophenylene
1,2-Aminoazophenylene
1,2-Aminozophenylene
1h-benzo
2,3-diazaindol
2,3-Diazaindole
2,3-Diazaindole 1,2,3-triazaindene | [EINECS(EC#)]
202-394-1 | [Molecular Formula]
C6H5N3 | [MDL Number]
MFCD00005699 | [Molecular Weight]
119.12 | [MOL File]
95-14-7.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow to beige solid | [Melting point ]
97-99 °C(lit.)
| [Boiling point ]
204 °C (15 mmHg)
| [density ]
1,36 g/cm3 | [vapor density ]
4.1 (vs air)
| [vapor pressure ]
0.04 mm Hg ( 20 °C)
| [refractive index ]
1.5589 (estimate) | [Fp ]
170 °C
| [storage temp. ]
Store below +30°C. | [solubility ]
19g/l | [form ]
Powder, Granules, Crystals, Needles or Flakes | [pka]
1.6(at 20℃) | [color ]
White to yellow-beige | [Odor]
Slight characteristic odor | [PH]
6.0-7.0 (100g/l, H2O, 20℃)suspension | [Stability:]
Stable, but may be light sensitive. Incompatible with strong oxidizing agents, heavy metals. | [explosive limit]
2% | [Water Solubility ]
25 g/l in water (20 ºC) | [Merck ]
14,1108 | [BRN ]
112133 | [InChIKey]
QRUDEWIWKLJBPS-UHFFFAOYSA-N | [CAS DataBase Reference]
95-14-7(CAS DataBase Reference) | [NIST Chemistry Reference]
1H-Benzotriazole(95-14-7) | [EPA Substance Registry System]
95-14-7(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi,F | [Risk Statements ]
R20/22:Harmful by inhalation and if swallowed .
R36:Irritating to the eyes.
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R5:Heating may cause an explosion.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R11:Highly Flammable. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
2811 | [WGK Germany ]
1
| [RTECS ]
DM1225000
| [Autoignition Temperature]
400 °C | [Hazard Note ]
Harmful/Irritant | [TSCA ]
Yes | [HS Code ]
29339990 | [Hazardous Substances Data]
95-14-7(Hazardous Substances Data) | [Toxicity]
LD50 orally in Rabbit: 560 mg/kg LD50 dermal Rabbit > 2000 mg/kg |
| Hazard Information | Back Directory | [General Description]
White to light tan crystals or white powder. No odor. | [Reactivity Profile]
The triazoles are a group of highly explosive materials that are sensitive to heat, friction, and impact. Sensitivity varies with the type substitution to the triazole ring. Metal chelated and halogen substitution of the triazol ring make for a particularly heat sensitive material. Azido and nitro derivatives have been employed as high explosives. No matter the derivative these materials should be treated as explosives. | [Air & Water Reactions]
Dust may form an explosive mixture in air. Slightly soluble in water. | [Hazard]
Highly toxic by ingestion. May explode under vacuum distillation. | [Health Hazard]
ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes. This compound can react violently during vacuum distillation. | [Fire Hazard]
Flash point data are not available for this compound. 1,2,3-BENZOTRIAZOLE(95-14-7) is probably combustible. | [Chemical Properties]
yellow to beige solid | [Uses]
anticorrosive agent in cooling fluids fuels, photographic development, antifreeze, dry cleaning, art restoration; tarnish remover and protective coatings in construction industry.
Benzotriazole is used as a component of aircraft de-icing fluid, pickling inhibitor in boiler scale removal, restrainer, developer and antifogging agent in photographic emulsions, corrosion inhibitor for copper, chemical intermediate for dyes, in pharmaceuticals, and as fungicide. (HSDB 1998).
Benzotriazole(BTA), ethylenediamine tetraaceticacid(EDTA), and potassium iodide(KI) were used for preparing the polishing slurries.
| [Uses]
Benzotriazole (BT) is an anticorrosive agent well known for its use in aircraft deicing and antifreeze fluids but also used in dishwasher detergents.
in vivo. | [Application]
1H-Benzotriazole main used as an anticorrosive in metalworking, in art restoration, and as a tarnish remover and protective coating in the construction industry.
In the aircraft industry, 1H-benzotriazole and tolyl benzotriazole are found to be the primary agents in most types of aircraft deicing/antiicing fluid (ADAFs).
Benzotriazole is also used as a component of aircraft deicing fluid, pickling inhibitor in boiler scale removal, restrainer, developer and antifogging agent in photographic emulsions, corrosion inhibitor for copper, chemical intermediate for dyes, in pharmaceuticals, and as fungicide. (HSDB 1998).
Benzotriazole(BTA), ethylenediamine tetraaceticacid(EDTA), and potassium iodide(KI) were used for preparing the polishing slurries. | [Definition]
ChEBI: The simplest member of the class of benzotriazoles that consists of a benzene nucleus fused to a 1H-1,2,3-triazole ring. | [Preparation]
Damschrodner and Peterson were able to synthesize the 1H-benzotriazole in a high yield (80%) by nitrosation of o-phenylenediamine with sodium nitrite in glacial acetic acid and water.
Synthesis of 1H-benzotriazole via diazotization of o-phenylenediamine
Reaction: Add o-phenylenediamine to 50°C water to dissolve, then add glacial acetic acid, cool down to 5°C, add sodium nitrite to stir the reaction. The reactant gradually turned dark green, the temperature rose to 70-80 ℃, the solution turned orange-red, placed at room temperature for 2 hours, cooled, filtered out the crystals, washed with ice water, dried to obtain the crude product, the crude product was distilled under reduced pressure, and collected 201 -204°C (2.0kPa) fraction, and then recrystallized with benzene to obtain 1H-Benzotriazole products with a melting point of 96-97°C, with a yield of about 80%. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 27, p. 185, 1962 DOI: 10.1021/jo01048a046 | [Flammability and Explosibility]
Nonflammable | [Safety Profile]
Poison by intravenous route.Moderately toxic by ingestion and intraperitoneal routes.Questionable carcinogen with experimental tumorigenicdata. Mutation data reported. May detonate at 220°C or during vacuum distillation. When heated to decompositionit | [Potential Exposure]
Because benzotriazoles are used in large quantities as a corrosion inhibitor, it is mainly through this type of use that benzotriazoles become an environmental contaminant. As a corrosion inhibitor and fire retardant, they are used in antifreeze in concentrations of 0.01-2.0% and in airplane deicing/antiicing fluids in unknown concentrations, up to 10% (Cancilla et al.,1997). Used antifreeze may leak or be poured down drains and thence enters the environment. Also, an estimated 80% of aircraft deicing/anti-icing fluids are deposited on the ground due to spray drift, jet blast, and wind shear during taxiing and takeoff, according to a recent study (Hartwell et al., 1995). | [Carcinogenicity]
Chronic (2-year) feeding studies
were conducted. Rats were given 0, 6700, or 12,000 ppm
in feed for 78 weeks and held for an additional 26 weeks.
Mice were given 0, 11,700, or 23,500 ppm in feed in
104 weeks. The authors concluded that under the conditions
shown in this study, there were no convincing
evidence that 1-H-benzotriazole was carcinogenic in rats
or mice. | [Purification Methods]
1,2,3-Benzotriazole crystallises from toluene, CHCl3, Me2NCHO or a saturated aqueous solution, and is dried at room temperature or in a vacuum oven at 65o. Losses are less if the material is distilled in a vacuum. CAUTION: may EXPLODE during distillation; necessary precautions must be taken. [Damschroder & Peterson Org Synth Coll Vol III 106 1955, Beilstein 26 III/IV 93.] | [Toxicity evaluation]
According to a 1977 EPA report, benzotriazole is considered to be of very low toxicity and a low health hazard to humans. In the same EPA report, two benzotriazole derivatives were reported to be mutagenic in bacterial systems. A year later, NIH published a report that there was no convincing evidence that the compound is carcinogenic (NIH, 1978). It is, however, more recently well established that 1-amino benzotriazole, with an amino group attached to one of the ring nitrogens, is a potent mechanism-based inhibitor of cytochrome P-450s via a benzyne intermediate (Ortiz de Montellano and Mathews, 1981), indicating that benzotriazoles as a class may interact with the P-450s. The P450s are important both for detoxifying a broad range of xenobiotics and for activating many compounds to carcinogens in mammalian systems. |
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