| Identification | More | [Name]
Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate | [CAS]
132705-51-2 | [Synonyms]
BROMOTRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE
BROMO-TRIS-PYRROLIDINO-PHOSPHONIUM HEXAFLUOROPHOSPHATE
BROMO-TRIS-PYRROLIDINO-PHOSPHONIUM HEXFLUOROPHOSPHATE
PYBROP
PYBROP(R)
PYBROP(TM)
Pybrop(Bromo-Tris-PyrrolidinophosphoniumHexafluorophosphate)
PyBroP\(rg
Bromotri(pyrrolidin-1-yl)phosphoniumhexafluorophosphate
Pyrrolidine phosphorus complex
Bromo-tris-pyrrolidino-phosphonium hexafluorophosphat
Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate ,97%
Bromotri(1-pyrrolidinyl)phosphonium hexafluorophosphate, 97% | [EINECS(EC#)]
620-834-4 | [Molecular Formula]
C12H24BrF6N3P2 | [MDL Number]
MFCD00077412 | [Molecular Weight]
466.18 | [MOL File]
132705-51-2.mol |
| Chemical Properties | Back Directory | [Appearance]
white to off-white powder | [Melting point ]
100 °C | [storage temp. ]
−20°C
| [solubility ]
DMF: 0.4 g/mL, clear
| [form ]
Powder | [color ]
White to off-white | [Water Solubility ]
moderately soluble | [Sensitive ]
Moisture Sensitive | [Detection Methods]
HPLC | [BRN ]
7845702 | [InChIKey]
CYKRMWNZYOIJCH-UHFFFAOYSA-N | [CAS DataBase Reference]
132705-51-2(CAS DataBase Reference) | [Storage Precautions]
Store under nitrogen;Moisture sensitive |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [F ]
10-21 | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
white to off-white powder | [Uses]
It can be used as a coupling reagent:
- For Suzuki–Miyaura cross-coupling of phenols and arylboronic acids to synthesize biaryls and heterobiaryls.
- To functionalize pyrimidines (synthesized from 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) via the Kappe dehydrogenation) by using various nucleophiles.
- To synthesize formamidines by coupling with various primary amines and N,N-diisopropylethylamine.
It can also be used as an activating reagent:
- For the activation of C-OH bond in tautomerizable heterocycles to form the phosphonium salt which aids the Sonogashira coupling of heterocycles with various alkynes.
- For the one–pot activation of C-O bond in phenols and further coupling reaction with phosphine oxide or phosphite to form C-P bonds.
| [Uses]
A stable reagent for the coupling of N-Methylamino acids in peptide synthesis. |
|
|