| Identification | Back Directory | [Name]
PD 124895 | [CAS]
107140-30-7 | [Synonyms]
CL-1957E
PD 124895
Kazusamycin B
Antibiotic CL-1957E
Antibiotic PD-124895
HydroxyleptoMycin A, CL 1957E, PD 124895, PD 124,895
4,8,10,14,18,20,22-Heptamethyl-16-hydroxymethyl-5,19-dihydroxy-17-oxo-2,6,8,12,14,22-tetracosahexenedioic acid δ-lactone
6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15,17-hexamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid
2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15,17-hexamethyl-8-oxo-, (2E,10E,12E,16Z,18E)- | [Molecular Formula]
C32H46O7 | [MDL Number]
MFCD01716600 | [MOL File]
107140-30-7.mol | [Molecular Weight]
542.7 |
| Hazard Information | Back Directory | [Uses]
Kazusamycin B is a minor component of the leptomycin complex produced by some Streptomyces sp.. It is an hydroxylated analogue of leptomycin A, a nuclear export inhibitor. Kazusamycin B displays potent antitumour activity against L1210 and human colon adenocarcinoma, and in vivo activity against P388 lymphocytic leukemia in mice. Kazusamycin B also possesses strong antibacterial and antifungal activity. | [Uses]
Kazusamycin B is a minor component of the leptomycin complex that displays anti-bacterial & anti-fungal activity. |
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