| Identification | Back Directory | [Name]
CHARTREUSIN | [CAS]
6377-18-0 | [Synonyms]
u-7257
nsc5159
CHARTREUSIN
LAMBDAMYCIN
antibioticx-465a
chartreusin from streptomyces*chartreusis
LaMbdaMycin, NSC 5159, 747, 1293, X465A, G 261A
10-[[6-Deoxy-2-O-(6-deoxy-3-O-methyl-α-D-galactopyranosyl)-β-D-galactopyranosyl]oxy]-6-hydroxy-1-methylbenzo[h][1]benzopyrano[5,4,3-cde][1]benzopyran-5,12-dione
Benzo[h][1]benzopyrano[5,4,3-cde][1]benzopyran-5,12-dione, 10-[[6-deoxy-2-O-(6-deoxy-3-O-methyl-α-D-galactopyranosyl)-β-D-galactopyranosyl]oxy]-6-hydroxy-1-methyl- | [Molecular Formula]
C32H32O14 | [MDL Number]
MFCD00467138 | [MOL File]
6377-18-0.mol | [Molecular Weight]
640.59 |
| Chemical Properties | Back Directory | [Melting point ]
185℃ | [alpha ]
D25 +132.5° (c = 0.2 in pyridine); D25 -33° (c = 0.3 in glacial acetic acid) | [Boiling point ]
592.39°C (rough estimate) | [density ]
1.3027 (rough estimate) | [refractive index ]
1.6130 (estimate) | [storage temp. ]
2-8°C | [solubility ]
Chloroform (Slightly, Heated), Methanol (Slightly), Pyridine (Slightly) | [form ]
Yellow solid. | [color ]
Light Yellow to Yellow | [Water Solubility ]
15mg/L(25 ºC) | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
Chartreusin is an antiproliferative agent that inhibits topoisomerase II. | [Uses]
Chartreusin is an antitumor antibiotic that binds to GC-rich tracts in DNA, with a clear preference for B-DNA over Z-DNA. It inhibits RNA synthesis and causes single-strand scission of DNA via the formation of free radicals. Chartreusin is also a potent inhibitor of topoisomerase II. | [Uses]
Chartreusin is an antitumour antibiotic that binds to GC-rich tracts in DNA, with a clear preference for B-DNA over Z-DNA. It inhibits RNA synthesis and causes single-strand scission of DNA via the formation of free radicals. Chartreusin is also a potent inhibitor of topoisomerase II. | [Definition]
ChEBI: Chartreusin is a glycoside and a benzochromenone. |
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Energy Chemical
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