Pyrimethamine synthesis

5synthesis methods

Product Name:Pyrimethamine
CAS Number:58-14-0
Molecular formula:C12H13ClN4
Molecular Weight:248.71

Pyrimethamine, 2,4-diamino-5-(4-chlorophenyl)-6-ethylpyrimidine (33.1.60), is synthesized from 4-chlorobenzycyanide, which upon condensation with methyl ester of propionic acid in the presence of sodium methoxide gives the β-ketonitrile (33.1.58). Reacting this with ethyl orthoformate gives a methoxymethylene derivative (33.1.59), which upon heterocyclization in pyrimidine using guanidine as the binucleophile forms the desired pyrimethamine (33.1.60).

140-53-4
480 suppliers
$13.00/25g

58-14-0
465 suppliers
$5.00/100mg

5-(4-chlorophenyl)pyrimidine-2,4-diamine

17039-14-4
7 suppliers
inquiry

4433-63-0 Synthesis

4433-63-0
287 suppliers
$5.00/1g

58-14-0
465 suppliers
$5.00/100mg

References

1679-18-1 Synthesis

1679-18-1
605 suppliers
$10.00/1g

514854-13-8 Synthesis

514854-13-8
46 suppliers
$36.00/100mg

58-14-0
465 suppliers
$5.00/100mg

References

62538-21-0 Synthesis

62538-21-0
73 suppliers
$33.93/250mgs:

58-14-0
465 suppliers
$5.00/100mg

References

95458-40-5
1 suppliers
inquiry

58-14-0
465 suppliers
$5.00/100mg

References

Pyrimethamine Related Search:

Uracil Ethanol Ethyl acetate L-1-Phenylethylamine Sulfadiazine Phenethyl chloride Triphenylmethyl Chloride tert-Butylchlorodiphenylsilane Pyrimidine Triethylamine