ChemicalBook CAS DataBase List PHT-LEU-OH

PHT-LEU-OH synthesis

5synthesis methods

Product Name:PHT-LEU-OH
CAS Number:2419-38-7
Molecular formula:C14H15NO4
Molecular Weight:261.27

61-90-5 Synthesis

61-90-5
793 suppliers
$10.00/25G

22509-74-6 Synthesis

22509-74-6
238 suppliers
$9.00/5g

2419-38-7
57 suppliers
$11.19/1G

Yield:2419-38-7 100%

Reaction Conditions:

with sodium carbonate in water at 20; for 2 h;

Steps:

2

L-leucine (5.12 g, 39.1 mmol) and Na₂CO₃ (4.14 g, 39.1 mmol) were dissolved in 40 mL distilled H₂O. The solution was added 7V-carbethoxy-phathalimide (8.55 g, 39.1 mmol) and then stirred at room temperature for 2 h. The resultant clear solution was acidified using 6 N HCl to pH=0 and then extracted with hexanes (3* 100 mL). The combined organic layers were dried in vacuo. Column chromatography on silica gel was applied eluting with hexanes/acetone (3:1) to get JV-phthalimide-L-leucine (1) (10.2 g, 39.1 mmol, quantitative) as colorless oil. ¹H NMR (400 MHz, CDCl₃) ￡0.92 (d, J=6.70 Hz, 3 H), 0.94 (d, J=6.70 Hz, 3 H), 1.37 - 1.60 (m, 1 H), 1.95 (ddd, J=14.31, 10.05, 4.26 Hz, 1 H), 2.36 (ddd, 7=14.31, 10.05, 4.26 Hz, 1 H), 4.99 (dd, J=I 1.57, 4.26 Hz, 1 H), 7.73 (dd, 7=5.48, 3.05 Hz, 2 H), 7.85 (dd, 7=5.48, 3.05 Hz, 2 H), 11.32 (br. s., 1 H); ¹³C NMR (75 MHz, CDCl₃) δ: 21.2, 23.3, 25.3, 37.2, 50.6, 123.8, 131.9, 134.4, 167.9, 176.0

References:

WO2010/20055,2010,A1 Location in patent:Page/Page column 68

85-44-9 Synthesis