Oleanolic acid synthesis
- Product Name:Oleanolic acid
- CAS Number:508-02-1
- Molecular formula:C30H48O3
- Molecular Weight:456.7
1458622-89-3
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508-02-1
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Yield:508-02-1 3.5 mg
Reaction Conditions:
with hydrogenchloride in chloroform;water; for 6 h;Reflux;
Steps:
Two-phase acid hydrolysis and determination of aglycones of 1-5:
General procedure: Due to the less quantity of saponins 1, 2 and 4, their mixture (15mg) was carried out in a solution of 10% hydrochloric acid (50mL) and CHCl3 (25mL) under reflux for 6h. After cooling, the CHCl3 layer was washed with H2O (3×2mL) and concentrated in vacuo. The residue was chromatographed on Sephadex LH-20 using MeOH as eluent to yield the glycone (siaresinolic acid, 2.8mg). This compound was identified by ESIMS and NMR. The aglycones of 3 and 5 were obtained using the same method (oleanolic acid, 3.5mg for 3 and hederagenin, 4.2mg for 5). The identification date of these aglycones see Supplementary data.
References:
Wang, Xiao-Yang;Gao, Hui;Zhang, Wei;Li, Yuan;Cheng, Guang;Sun, Xiao-Li;Tang, Hai-Feng [Bioorganic and Medicinal Chemistry Letters,2013,vol. 23,# 20,p. 5714 - 5720]
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152487-68-8
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508-02-1
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$29.00/1g
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508-02-1
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1351948-52-1
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58-86-6
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508-02-1
535 suppliers
$29.00/1g