2-Chloro-N,N-diethylacetamide synthesis
- Product Name:2-Chloro-N,N-diethylacetamide
- CAS Number:2315-36-8
- Molecular formula:C6H12ClNO
- Molecular Weight:149.62
Yield:2315-36-8 100%
Reaction Conditions:
in dichloromethane;water at 5;Temperature;Solvent;
Steps:
1-8 Example 1 Preparation of N,N-diethylchloroacetamide
Add 425Kg of dichloromethane to the reaction kettle, and then add 90.5Kg of diethylamine, and then add 70.2Kg of chloroacetyl chloride to the reaction kettle under the temperature control condition of 5±5°C, and keep it at 5±5°C after dropping. And stir for 190 minutes; then add 130.3Kg of water into the reaction kettle, stir for 35 minutes, stand for layering, take the organic layer, add 63.3Kg of water and 23.7Kg of sodium chloride, stir for 35 minutes, stand for layering, and take the organic layer. Layer, 50±3 normal pressure recovery dichloromethane to the condenser, then 50±3 reduced pressure to recover the dichloromethane until the condenser does not come out; then keep the temperature and vacuum constant, continue to recover for 5 hours, put N,N-diethyl chloroacetamide is obtained from the raw material with a purity of 98.4% and a yield of nearly 100%.
References:
CN112479913, 2021, A Location in patent:Paragraph 0052; 0055-0065
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