Methyl indolyl-3-glyoxylate synthesis
- Product Name:Methyl indolyl-3-glyoxylate
- CAS Number:18372-22-0
- Molecular formula:C11H9NO3
- Molecular Weight:203.19
120-72-9
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67-56-1
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79-37-8
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18372-22-0
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$8.00/250mg
Yield: 90%
Reaction Conditions:
Stage #1:indole;oxalyl dichloride in diethyl ether at 0 - 20; for 6 h;
Stage #2:methanol in diethyl ether at 0; for 0.5 h;
Steps:
Preparation of compound methyl 2-(1H-indol-3-yl)-2-oxoacetate (1)
In a reaction flask,7 g ( 60 mmol ) indole and 300 mL of dry diethyl ether were add, and 16.1 mL of oxalyl chloride was added dropwise to the reaction solution at 0 °C. The reaction was continued for 6 h at room temperature to form a yellow suspension. It was further placed at 0° C, 12 mL of methanol was added dropwise to the reaction, and the mixture was stirred for 30 min. The resulting mixture was filtered and washed with ice ether to finally obtain a yellow solid 1 ( 10.93 g , 90% yield).
References:
Guo, Zhenbo;Xu, Yiming;Peng, Yujie;Haroon ur Rashid;Quan, Wei;Xie, Peng;Wu, Lichuan;Jiang, Jun;Wang, Lisheng;Liu, Xu [Bioorganic and Medicinal Chemistry Letters,2019,vol. 29,# 9,p. 1133 - 1137] Location in patent:supporting information
120-72-9
646 suppliers
$6.00/25g
79-37-8
478 suppliers
$17.67/10gm:
124-41-4
708 suppliers
$12.00/25g
18372-22-0
152 suppliers
$8.00/250mg
67-56-1
771 suppliers
$7.29/5ml-f
1477-49-2
132 suppliers
$10.00/100mg
18372-22-0
152 suppliers
$8.00/250mg
22980-09-2
75 suppliers
$39.00/1g
124-41-4
708 suppliers
$12.00/25g
18372-22-0
152 suppliers
$8.00/250mg
120-72-9
646 suppliers
$6.00/25g
18372-22-0
152 suppliers
$8.00/250mg