Methyl 2-chloro-6-methylpyridine-4-carboxylate synthesis
- Product Name:Methyl 2-chloro-6-methylpyridine-4-carboxylate
- CAS Number:3998-90-1
- Molecular formula:C8H8ClNO2
- Molecular Weight:185.61
25462-85-5
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$6.00/250mg
79-37-8
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$17.67/10gm:
3998-90-1
202 suppliers
$4.00/1g
Yield:3998-90-1 100%
Reaction Conditions:
in methanol;dichloromethane
Steps:
63 Example 63
The starting material was prepared as follows: Oxalyl chloride (1.9 g, 15 mmol) was added to 2-chloro-6-methyl-pyridine4-carboxylic acid (1.7 g, 10 mmol) in methylene chloride (30 ml) and the mixture stirred for 2 hours. The volatiles were removed by evaporation and methanol (20 ml) added to the residue. The mixture was stirred for 1 hour and the volatiles removed by evaporation to give methyl 2-chloro-6-methyl-pyridine-4-carboxylate (1.85 g, 100%) as an off-white solid. 1 H NMR Spectrum: (CDCl3) 2.55(s, 3H); 3.90(s, 3H); 7.55(s, 1H); 7.60(s, 1H); MS - ESI: 186 [MH]+
References:
Zeneca Limited;Zeneca Pharma S.A., US5962458, 1999, A
67-56-1
751 suppliers
$7.29/5ml-f
86454-13-9
99 suppliers
$10.00/250mg
3998-90-1
202 suppliers
$4.00/1g
67-56-1
751 suppliers
$7.29/5ml-f
25462-85-5
233 suppliers
$6.00/250mg
3998-90-1
202 suppliers
$4.00/1g
98491-78-2
51 suppliers
$24.00/250 mg
3998-90-1
202 suppliers
$4.00/1g
86454-13-9
99 suppliers
$10.00/250mg
3998-90-1
202 suppliers
$4.00/1g