Methyl (1-benzyl-4-Methylpiperidin-3-yl)carbaMate synthesis
- Product Name:Methyl (1-benzyl-4-Methylpiperidin-3-yl)carbaMate
- CAS Number:1206875-41-3
- Molecular formula:C15H22N2O2
- Molecular Weight:262.35
923036-28-6
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1206875-41-3
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Yield:1206875-41-3 66%
Reaction Conditions:
with hydrogen;platinum(IV) oxide in methanol at 60; for 16 h;
Steps:
1.5
Step 5O o/ Nx N" "or ^ Nx^JN' O H H[00155] Methyl l-benzyl-4-methylpiperidin-3-yl-carbamate: Platinum oxide (1.0 g, 4.41 mmol, 0.11 equiv.) was added to a solution of methyl l-benzyl-4- methyl- 1,2, 5, 6-tetrahydropyndin-3-ylcarbamate (10 g, 38.46 mmol, 1.00 equiv.) in methanol (200 mL). After introducing hydrogen gas, the mixture was stirred at about 60 0C for about 16 hours and then was filtered. The resulting filtrate was concentrated to give a crude residue that was then purified by silica gel column chromatography (ethyl acetate / petroleum (1:2)) to afford the title product a yellow solid (7 g; yield = 66%). LC-MS: m/z = 263 (M+H)+.
References:
WO2010/123919,2010,A2 Location in patent:Page/Page column 50-51