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ChemicalBook CAS DataBase List N-((3R,4S)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
1092578-45-4

N-((3R,4S)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine synthesis

1synthesis methods
Tofacitinib Impurity 20

1092578-44-3
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N-((3R,4S)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

1092578-45-4
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Yield:-

Reaction Conditions:

with water;sodium hydroxide for 6 h;Reflux;

References:

Jiang, Jian-Kang;Ghoreschi, Kamran;Deflorian, Francesca;Chen, Zhi;Perreira, Melissa;Pesu, Marko;Smith, Jeremy;Nguyen, Dac-Trung;Liu, Eric H.;Leister, William;Costanzi, Stefano;O'Shea, John J.;Thomas, Craig J. [Journal of Medicinal Chemistry,2008,vol. 51,# 24,p. 8012 - 8018] Location in patent:supporting information; experimental part

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